To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, its association with hemodynamics metabolic parameters.Methods: Male Wistar rats were divided into control (Cont) STZ-induced (Diab). Half from each group received a single dose (100 mg/Kg) before STZ injection (Cont+NicA Diab+NicA). All groups followed-up for 5 weeks.Body weight loss more than 40% was observed Diab throughout period (Diab:...

High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of in derangements a rat model. Wistar rats receiving overload drinking water (100 g/l) were concomitantly trained on treadmill (FT) or kept sedentary (F) for 10 wk. Control treated with normal also submitted (CT) sedentarism (C). Metabolic evaluations consisted Lee index and glycemia insulin tolerance...

Deep Neural Networks (DNNs) enable a wide series of technological advancements, ranging from clinical imaging, to predictive industrial maintenance and autonomous driving. However, recent findings indicate that transient hardware faults may corrupt the models prediction dramatically. For instance, radiation-induced misprediction probability can be so high impede safe deployment DNNs at scale, urging need for efficient effective hardening solutions. In this work, we propose tackle reliability...

Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI particularly challenging because the two therapeutic strategies for HS conflict. Ischemia/reperfusion from resuscitation can be exaggerated TBI-induced loss autoregulation. In resuscitation, goal to restore lost blood volume, while in priority focused on maintenance adequate cerebral perfusion pressure avoidance secondary bleeding. this study, we investigate responses...

Restriction of sodium intake has been shown to decrease urinary elimination cystine in adult subjects with cystinuria. This simple therapeutic recommendation may be particularly useful pediatric patients whose compliance high fluid ingestion and repeated doses alkali is usually poor. We studied the effect 5 cystinuric children (3 males) aged 5.9-9.3 years. Urinary excretion (x ± SD) was determined at end two sequential 1-week periods which content diet modified. Reduction brought about...

Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients septic shock, the mortality associated with sepsis-induced AKI unacceptably high. Klotho protein expressed renal cells has anti-senescence properties. also been shown to protect kidneys ischemia-reperfusion have antioxidant To analyze role sepsis-related dysfunction AKI, we used cecal ligation puncture (CLP) model sepsis...

Background: After a Stroke, there is an autonomic nervous system (ANS) changes. Transcranial Direct Current Stimulation (tDCS) can promote the reorganization of affected circuits. Objective: To evaluate effects tDCS applied before session physical activity on treadmill, in modulation post-stroke patients. Methodology: Cross-over study, were randomized 12 adult hemiparetic subjects 2 groups, Group 1 (active exercise treadmill) and (sham treadmill). times 20 minutes; treadmill time was...

Introduction: Infection by SARS-CoV-2 and subsequent COVID-19 can cause viral sepsis. We investigated plasma protease activity patterns in COVID-19-induced sepsis with bacterial superinfection, as well proteomics peptidomics order to assess the possible implications of enhanced proteolysis on major protein systems (e.g., coagulation). Methods: Patients (=4) admitted intensive care units (ICUs) at University California, San Diego (UCSD) Medical Center confirmed positive test for real-time...

The analysis of heart rate variability (HRV) has been shown as a promising non-invasive technique for assessing the cardiac autonomic modulation in trauma. aim this study was to evaluate HRV during hemorrhagic shock and fluid resuscitation, comparing traditional hemodynamic metabolic parameters.Twenty anesthetized mechanically ventilated pigs were submitted (60% estimated blood volume) evaluated 60 minutes without replacement. Surviving animals treated with Ringer solution an additional...

A number of mechanisms have been proposed to explain the pleiotropic effect statin therapy reduce sympathetic outflow in cardiovascular disease. We tested hypothesis that treatment could improve baroreflex gain-sensitivity triggered by morphological adaptations mechanoreceptor site, thus reducing activity, regardless arterial pressure (AP) level reduction. Male spontaneously hypertensive rats (SHR) were divided into control (SHR, n = 8) and SHR-simvastatin (5 mg/kg/day, for 7 days) (SHR-S,...

It is well-established that baroreflex sensitivity essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate cardiometabolic inflammatory derangements promoted by fructose overload, Wistar rats underwent sinoaortic denervation (SAD) or sham surgery were studied 90 days after receiving tap water (Den Ctrl) 10% solution (Fruc Den-Fruc). All experimental groups showed marked similar degree impairment...

We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar were separated groups: control, drinking tap water (C), tea-treated (GT) group, diabetic, (D), tea (DGT). Kidney mass was greater D DGT than C GT, but reduced compared to D. Green prevented the increase creatinine clearance hyperglycemia Arterial increased GT decreased C. HRV all groups. APV recovery...

To evaluate autonomic and cardiovascular function, as well inflammatory oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac arterial pressure (AP), autonomic, hormonal, were evaluated 12-weeks wild-type (WT group) mice (OB group). Results: OB animals showed increased body weight, blood glucose, triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction AP similar between groups; however, the group presented diastolic...

Peripheral arterial disease, as measured by the ankle-brachial index (ABI), is prevalent among elderly, and associated with functional performance, assessed 6-minute walk test (6MWT). Executive cognitive function (ECF) impairments are also in this population, but no existing study has investigated association between ECF performance an elderly population including individuals low ABI.To investigate 6MWT, loss ECF, sample ABI.The ABI group was formed 26 (mean ABI: 0.63±0.19), control 40...

Objective: This study evaluated the effects of aerobic, resistance and combined exercise training on cardiac function autonomic modulation in female ob/ob mice. Methods: 4-week-old wild type obese (ob/ob) mice were divided into 5 groups (n=8): control (WT), (OB) obese+aerobic (OBA), obese+resistance (OBR) obese+combined (OBC). The was performed treadmill and/or ladder at 40-60% maximum test during 8 weeks. Cardiac measured using echo machine. Heart rate variability (HRV) time frequency...

Aim: We employed an echocardiographic (ECHO) system as the backbone for collection of electrocardiogram (ECG) and heart rate variability (HRV) data. The was tested using exercise model in which C57 male mice were exposed to sham or forced wheel running. Methods: Peak/peak (RR) interval recorded over a 3 min period ECG platform ECHO system. Isoflurane-anesthetized divided into two groups (n = 8/group): sedentary (S) trained (T). HRV analyzed time frequency domains (Fast Fourier Transform)....

Easy access to high-calorie and fat-dense fast food has resulted in unhealthy dietary lifestyle changes worldwide, which affects both developed developing economies. This predisposes populations a considerable number of metabolic inflammatory conditions, such as diabetes, nonalcoholic fatty liver disease (NAFLD), cardiovascular (CVD). Guinea pigs have been proposed model study high-fat diet-induced due their similar antioxidant metabolism lipid profile humans, susceptibility atherosclerosis...