A5077188322- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Hemoglobin structure and function
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- SARS-CoV-2 and COVID-19 Research
- Blood transfusion and management
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Biochemical Analysis and Sensing Techniques
- Blood donation and transfusion practices
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Mechanical Circulatory Support Devices
University of California, San Diego
2017-2023
La Jolla Bioengineering Institute
2018-2022
VA San Diego Healthcare System
2017-2021
Politecnico di Milano
2017
Conference Board
2017
Matrix metalloproteinase–2 inhibition rescued leptin receptor expression in the hypothalamus and reduced fat accumulation rodent models of obesity.
Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI particularly challenging because the two therapeutic strategies for HS conflict. Ischemia/reperfusion from resuscitation can be exaggerated TBI-induced loss autoregulation. In resuscitation, goal to restore lost blood volume, while in priority focused on maintenance adequate cerebral perfusion pressure avoidance secondary bleeding. this study, we investigate responses...
Introduction: Infection by SARS-CoV-2 and subsequent COVID-19 can cause viral sepsis. We investigated plasma protease activity patterns in COVID-19-induced sepsis with bacterial superinfection, as well proteomics peptidomics order to assess the possible implications of enhanced proteolysis on major protein systems (e.g., coagulation). Methods: Patients (=4) admitted intensive care units (ICUs) at University California, San Diego (UCSD) Medical Center confirmed positive test for real-time...
BACKGROUND Irreversible hemorrhagic shock is characterized by hyporesponsiveness to vasopressor and fluid therapy. Little known, however, about the mechanisms that contribute this phenomenon. Previous studies have shown decreased intestinal perfusion in leads proteolytically mediated increases gut permeability, with subsequent egress of vasoactive substances systemically. Maintenance blood pressure achieved part α1 receptor modulation, which may be affected factors; we thus hypothesized...
Refractory vascular failure due to the inability of smooth muscle respond vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock any cause, including trauma/hemorrhagic shock. Increased inflammation, Toll-like receptor 4 activation, and decreased response alpha-1 adrenergic receptors which control tone have been reported in shock.In shock, activation contributes via bioavailability receptors.Trauma/hemorrhagic was induced Wistar rats (laparotomy...
Trauma-hemorrhagic shock (T-HS) is a major cause of multiorgan failure and mortality world-wide. Our previous work demonstrates that uncontrolled proteolysis in T-HS associated with poor outcomes enteral inhibition proteolytic activity may be beneficial. However, the enzymes involved, their degradation products, systemic consequences protease are not well understood. aim was to identify plasma enzymatic resulting peptidome experimental T-HS, determine changes this following inhibition....
Preserving vascular function is crucial for preventing multiorgan failure and death in ischemic low-pressure states such as trauma/hemorrhagic shock (T/HS). It has recently been reported that inhibiting circulating proteases released from the bowel to circulation during T/HS may preserve improve outcomes following T/HS. This study aimed evaluate role of serine protease inhibitor gabexate mesilate (GM) preserving when given enterally. We studied reactivity mesenteric arteries male Wistar rats...
Objective Fluid resuscitation with blood products is standard of care in the current management trauma/hemorrhagic shock (T/HS). However, availability whole rare civilian prehospital care, and thus component therapy other fluid replacement options are required. This study sought to differentiate compare effects lactated Ringer’s solution (LR), plasma, washed red cells (RBC), (Control) as fluids for hemodynamic restoration after T/HS. Methods Wister male rats (400g) were randomly divided into...
Abstract Infection by SARS-CoV-2 and subsequent COVID-19 can cause viral sepsis septic shock. Several complications have been observed in patients admitted to the intensive care unit (ICU) with COVID-19, one of those being bacterial superinfection. Based on prior evidence that dysregulated systemwide proteolysis is associated death shock, we investigated whether protease activity could be elevated COVID-19-induced In particular, sought assess possible implications regulation protein systems,...