A5034927375- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Leptospirosis research and findings
- Dialysis and Renal Disease Management
- Sepsis Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Renal function and acid-base balance
- Muscle and Compartmental Disorders
- Parathyroid Disorders and Treatments
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Viral Infections and Vectors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease and Transplantation
- Chronic Kidney Disease and Diabetes
- Climate Change and Health Impacts
- Adrenal Hormones and Disorders
- Long-Term Effects of COVID-19
- Vitamin D Research Studies
- Magnesium in Health and Disease
- COVID-19 and healthcare impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Organ Transplantation Techniques and Outcomes
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008-2024
Clinica De Doencas Renais De Brasilia
2022
Public Health England
2021
Hospital São Paulo
2020
Universidade Federal do Rio de Janeiro
2019
Instituto de Infectologia Emílio Ribas
1999-2013
National Council for Scientific and Technological Development
2012
Universidade Brasil
2009
University of Buenos Aires
1974-2009
Forty-two consecutive patients with leptospirosis and acute lung injury who were mechanically ventilated analyzed in a prospective cohort study. Nineteen (45%) survived, 23 (55%) died. Multivariate analysis revealed that 3 variables independently associated mortality: hemodynamic disturbance (odds ratio [OR], 6.0; 95% confidence interval [CI], 0.9-38.8; P=. 047), serum creatinine level >265.2 micromol/L (OR, 10.6; CI, 0. 9-123.7; P =.026), potassium >4.0 mmol/L 19.9; 1.2-342.8; P=.009)....
Chronic kidney disease (CKD) is a public health problem worldwide, and proteinuria well-established marker of progression in CKD patients. Propolis, natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory, anti-oxidant properties, as well having been shown to have an antiproteinuric effect experimental CKD. The aim this study was evaluate the impact Brazilian green propolis extract on reduction changes estimated glomerular filtration rate (eGFR). This...
Abstract The pathophysiology of sepsis involves complex cytokine and inflammatory mediator networks. Downregulation endothelial nitric oxide synthase contributes to sepsis-induced dysfunction. Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are known reduce expression proinflammatory cytokines markers apoptosis. We hypothesized that treatment with WJ-MSCs would protect renal, hepatic, function in a cecal ligation puncture (CLP) model rats. Rats were randomly divided into three...
Background.N-Acetylcysteine has been shown to protect against contrast nephropathy, although the mechanisms underlying such an effect are unclear. Surprisingly, studies have that post-radiocontrast renal function actually improves in chronic failure patients receiving N-acetylcysteine. However, there no investigating cause of this improvement.
Background Despite advances in supportive care, sepsis-related mortality remains high, especially patients with acute kidney injury (AKI). Erythropoietin can protect organs against ischemia and sepsis. This effect has been linked to activation of intracellular survival pathways, although the mechanism unclear. Continuous erythropoietin receptor activator (CERA) is an a unique pharmacologic profile long half-life. We hypothesized that pretreatment CERA would be renoprotective cecal ligation...
Mesenchymal stromal cells (MSCs) represent an option for the treatment of acute kidney injury (AKI). It is known that young stem are better than aged at reducing incidence senescent phenotype in kidneys. The objective this study was to determine whether AKI leads premature, stress-induced senescence, as well human umbilical cord-derived MSCs (huMSCs) can prevent ischaemia/reperfusion (IRI)-induced renal senescence rats.By clamping both arteries 45 min, we induced IRI male rats. Six hours...
The pathophysiology of sepsis involves complex cytokine and inflammatory mediator networks, a mechanism to which NF-κB activation is central. Downregulation endothelial nitric oxide synthase (eNOS) contributes sepsis-induced dysfunction. Erythropoietin (EPO) has emerged as major tissue-protective in the setting stress. We investigated role EPO sepsis-related acute kidney injury using cecal ligation puncture (CLP) model. Wistar rats were divided into three primary groups: control...
Despite a significant improvement in the management of chronic kidney disease (CKD), its incidence and prevalence has been increasing over years. Progressive renal fibrosis is present CKD involves participation several cytokines, including Transforming growth factor-β1 (TGF-β1). Besides cardiovascular diseases infections, studies show that Vitamin D status considered as non-traditional risk factor for progression CKD. Given importance vitamin maintenance essential physiological functions, we...
Proteinuria is a marker and mediator of chronic kidney disease (CKD). In clinical practice, the urinary protein-to-creatinine ratio (UP/C) limited usefulness, because it indicates only magnitude proteinuria not origin loss (glomerular or tubular). The complete assessment includes quantitative qualitative evaluations, both which are required in order to optimize therapy. addition measuring UP/C, we performed SDS-PAGE western blotting determine expression albumin, vitamin D-binding protein...
Little is known about clinical characteristics and management of severe yellow fever as previous epidemics often occurred in times or areas with little access to intensive care units (ICU). We aim describe the cases requiring admission ICU during 2018 outbreak São Paulo, Brazil. Furthermore, we report on preliminary lessons learnt regarding fever.Retrospective descriptive cohort study. Demographic data, laboratory test results admission, follow-up, outcomes were evaluated.From 10 January 11...
This study aimed at assessing the effects of Kefir, a probiotic fermented milk, on oxidative stress in diabetic animals. The induction diabetes was achieved adult male Wistar rats using streptozotocin (STZ). animals were distributed into four groups as follows: control (CTL); Kefir (CTLK); (DM) and (DMK). Starting 5th day diabetes, administered by daily gavage dose 1.8 mL/day for 8 weeks. Before after treatment, placed individual metabolic cages to obtain blood urine samples evaluate urea,...
Leptospirosis is a public health problem, the severe form of which (Weil's disease) includes acute respiratory distress syndrome, typically accompanied by kidney injury (AKI), and associated with high mortality rates. Recent evidence suggests that dialysis dosage affects outcomes in critically ill patients sepsis-induced AKI. However, this population varies widely terms age, gender, concomitant conditions, making it difficult to determine appropriate timing (door-to-dialysis time) dosage.It...
Sepsis is a common cause of acute kidney injury (AKI) and lung injury. Oxidative stress plays as important role in such The aim this study was to evaluate the effects that potent antioxidant N-acetylcysteine (NAC) has on renal pulmonary function rats with sepsis. Rats, treated or not NAC (4.8 g/l drinking water), underwent cecal ligation puncture (CLP) 2 days after initiation treatment, which maintained throughout study. At 24 h post-CLP, were studied four groups: control, control + NAC,...
Lithium (Li)-treated patients often develop urinary concentrating defect and polyuria, a condition known as nephrogenic diabetes insipidus (NDI). In rat model of Li-induced NDI, we studied the effect that sildenafil (Sil), phosphodiesterase 5 (PDE5) inhibitor, has on renal expression aquaporin-2 (AQP2), urea transporter UT-A1, Na(+)/H(+) exchanger 3 (NHE3), Na(+)-K(+)-2Cl(-) cotransporter (NKCC2), epithelial Na channel (ENaC; α-, β-, γ-subunits), endothelial nitric oxide synthase (eNOS),...
Leptospirosis is an acute septicemic illness that affects humans in all parts of the world. Approximately 10% patients with leptospirosis develop severe disease, Weil syndrome, jaundice, kidney injury (AKI), and pulmonary hemorrhage. Leptospirosis-induced AKI typically nonoliguric a high frequency hypokalemia. Experimental clinical studies demonstrated tubular function alterations precede drop glomerular filtration rate are mainly proximal tubule. Studies animals have decrease expression...
Vitamin D deficiency (VDD) increases the risk of death in hospitalized patients. Renal ischemia/reperfusion injury (IRI) induces acute kidney (AKI), which activates cell cycle inhibitors, including p21, a cyclin-dependent kinase inhibitor and genomic target 25-hydroxyvitamin D, is turn potent immunomodulator with antiproliferative effects. In this study, we assess impact VDD renal IRI. Wistar rats were divided into groups, each evaluated for 30 days: control (receiving standard diet);...
Reductions in renal microvasculature density and increased lymphocyte activity may play critical roles the progression of chronic kidney disease (CKD) following acute injury (AKI) induced by ischemia/reperfusion (IRI). Vitamin D deficiency is associated with tubulointerstitial damage fibrosis IRI-AKI. We evaluated effect vitamin sustained IRI-AKI, hypothesizing that such contributes to early reduction capillary or alters response IRI. Wistar rats were fed D-free standard diets for 35 days....
A hérnia inguinal é uma das patologias mais prevalentes no campo da cirurgia, com alto índice de recorrência após o tratamento. Este estudo tem como objetivo analisar as taxas hérnias inguinais associadas a diferentes técnicas cirúrgicas, abordagem aberta Lichtenstein, laparoscópica e Técnica Endoscópica Total (TEP). As recidiva são influenciadas por vários fatores, experiência do cirurgião, características paciente técnica utilizada. embora eficaz, apresenta taxa 1 3%, principalmente em...
Background: Upper tract urothelial carcinoma (UTUC) is a rare malignancy, accounting for 5-10% of cancers, and traditionally managed with radical nephroureterectomy (RNU). Although RNU offers effective oncological control, it associated significant morbidity, including chronic kidney disease cardiovascular complications. Recent advancements in endoscopic technology have enabled minimally invasive approaches, particularly low-risk tumors, emphasizing preservation reducing treatment-related...
Inteligência Artificial no Monitoramento em Unidade de Terapia Intensiva (UTI) Qual o avanço da inteligência artificial na UTI? A busca pelo conhecimento prol dos avanços cuidado ao paciente crítico, adoção estratégias inovadoras e redefinição padrões sempre estiveram presentes dia a terapia intensiva. Em 1998, com criação um protocolo proteção pulmonar para pacientes que desenvolvem síndrome do desconforto respiratório agudo (SDRA) é exemplos transformadores individualização precisão...