A5023522072- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Complementary and Alternative Medicine Studies
- Sepsis Diagnosis and Treatment
- Phytochemistry Medicinal Plant Applications
- Dialysis and Renal Disease Management
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Insect and Pesticide Research
- COVID-19 Clinical Research Studies
- Muscle and Compartmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Renal function and acid-base balance
- Medical and Biological Ozone Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Atherosclerosis and Cardiovascular Diseases
- Pharmacology and Obesity Treatment
- Ion Transport and Channel Regulation
- Central Venous Catheters and Hemodialysis
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral Infections and Outbreaks Research
Hospital São Rafael
2020-2025
D’Or Institute for Research and Education
2020-2024
Universidade Federal da Bahia
2023
Hospital Pitangueiras
2022
Universidade de São Paulo
2016-2021
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2021
Universidade Estadual de Ciências da Saúde de Alagoas
2014
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against disease 2019 (COVID-19), the most adequate treatment has not yet established. Propolis is a natural product with considerable evidence of immunoregulatory anti-inflammatory activities, experimental data point to potential viral targets. We hypothesized that propolis can reduce negative effects COVID-19.In...
Chronic kidney disease (CKD) is a public health problem worldwide, and proteinuria well-established marker of progression in CKD patients. Propolis, natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory, anti-oxidant properties, as well having been shown to have an antiproteinuric effect experimental CKD. The aim this study was evaluate the impact Brazilian green propolis extract on reduction changes estimated glomerular filtration rate (eGFR). This...
Sepsis is the leading cause of acute kidney injury (AKI) and lung worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, immunomodulatory properties, we hypothesized that it would protect kidneys lungs in rats induced by cecal ligation puncture (CLP). Male Wistar were divided into groups-control (sham-operated); CLP (CLP only); + GP treatment at 6 h thereafter)-all...
Among candidate treatment options for COVID-19, propolis, produced by honey bees from bioactive plant exudates, has shown potential against viral targets and demonstrated immunoregulatory properties. We conducted a randomized, controlled, open-label, single center trial, with standardized propolis product (EPP-AF) on hospitalized adult COVID-19 patients. Patients received standard care plus at an oral dose of 400mg/day (n=40) or 800mg/day (n=42) seven days, alone (n=42). Standard included...
Sepsis is a dysregulated hyperinflammatory disease caused by infection. leads to multiple organ dysfunction syndrome (MODS), which associated with high rates of mortality. The cecal ligation and puncture (CLP) model has been widely used in animals become the gold-standard method replicating features sepsis humans. Despite several studies modified CLP protocols, there are still open questions regarding multifactorial determinants its reproducibility medical significance. In our protocol, also...
Introdução: Doenças cardiovasculares (DCVs) são as principais causas de mortalidade em pacientes portadores falência renal crônica (FRC). Diversos fatores risco estão envolvidos na patogênese e classificados tradicionais - que afetam a população geral; não peculiares aos renais crônicos. Hiperparatireoidismo secundário, um fator tradicional comum FRC, causa aumento da taxa reabsorção óssea mobilização do cálcio fósforo. À medida o produto x fósforo aumenta, solubilidade desse par iônico pode...
Patients on haemodialysis (HD) present a significant inflammatory status, which has pronounced negative impact their outcomes. Propolis is natural resin with anti-inflammatory and immunomodulatory properties. We assessed the safety of standardized Brazilian green propolis extract (EPP-AF®) status in patients under conventional HD. were assigned to receive 200 mg/day EPP-AF® for 4 weeks followed by without drug, changes plasma levels interleukins (ILs), interferon gamma (IFN-γ), tumour...
Abstract SARS-CoV-2 and its different variants caused a “wave wave” pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. Afterwards, decided to evaluate impact EPP-AF hospitalized during third pandemic. BeeCovid2 was randomized, double-blind, placebo-controlled clinical trial COVID-19 patients. Patients were allocated receive an oral dose 900 mg/day EPP-AF® or...
BACKGROUND:Corpus callosum agenesis (CCA) is one of the most common congenital brain abnormalities, and associated with neurodevelopmental neuropsychiatric disorders. In CCA, defects in osmoregulation have been reported. This report presents a rare case chronic hyponatremia syndrome inappropriate antidiuresis (SIAD) woman CCA. CASE REPORT:A 41-year-old presented to renal unit symptomatic hyponatremia. her past medical history, she had four-year history systemic arterial hypertension...
Abstract Background and Aims End-stage chronic kidney disease is associated with the condition of inflammation, impacting increased cardiovascular mortality in this specific population. Patients on hemodialysis are known to be predisposed several factors that predispose inflammation: dialysis membranes, central venous catheters, oxidative stress, fluid overload, sodium uraemic toxins. Propolis, a natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory,...
Coronavirus disease 2019 (COVID-19) is an emerging infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began as outbreak in Wuhan, China and has spread rapidly across the globe. Although most infections are mild, patients with critical COVID-19 face deterioration of function may also have extrapulmonary manifestations, mostly affecting kidney, digestive tract, heart, nervous system. Here, we prospectively evaluated presence SARS-CoV-2 genetic material...
There have been few studies investigating acute kidney injury (AKI) in patients with yellow fever (YF). The objective of this study was to identify the risk factors for AKI and death such patients.We evaluated 95 consecutive critically ill adult sylvatic form YF, as confirmed by reverse-transcriptase polymerase chain reaction, Brazil. outcome measures were (as defined Kidney Disease: Improving Global Outcomes [KDIGO] criteria) in-hospital death.Of patients, 73 (76.8%) had 59 (62.1%) died...
Abstract The novel coronavirus disease (COVID-19) is an emerging infectious caused by SARS-CoV-2, which began as outbreak in Wuhan, China and spread rapidly throughout the globe. Although majority of infections are mild, severe critical COVID-19 patients face deterioration respiratory function, may also present extrapulmonary manifestations, mostly affecting kidney, digestive tract, heart nervous system. Here, we prospectively evaluated presence SARS-CoV-2 genetic material RT-PCR urine...
BACKGROUND:Distal renal tubular acidosis (dRTA) is a defect in the urinary acidification process that limits elimination of protons [H+] by alpha intercalated cells collecting tubules, with consequent metabolic normal plasma anion gap. The relationship between this tubulopathy and immune-mediated diseases like Sjögren syndrome, rheumatoid arthritis, autoimmune hepatitis, primary biliary cirrhosis, systemic lupus erythematosus, thyroiditis well known. Further, pathophysiological mechanisms...
Abstract Background The 2019 coronavirus disease (COVID-19) pandemic continues to spread and affects large numbers of people with unprecedented impacts. Experimental evidence has already been obtained for use the standardized extract Brazilian green propolis (EPP-AF) against viral targets, clinical rationality demonstrated testing this as an adjunct treatment in patients affected by COVID-19. BeeCovid2 study aims assess whether EPP-AF impact on improvement hospitalized COVID-19 reducing...
BACKGROUND Acid-base imbalance has been poorly described in patients with coronavirus disease 2019 (COVID-19). Study by the quantitative acid-base approach may be able to account for minor changes ion distribution that have overlooked using traditional analysis techniques. In a cohort of critically ill COVID-19 patients, we looked an association between metabolic acidosis surrogates and worse clinical outcomes, such as mortality, renal dialysis, length hospital stay. AIM To describe...
Abstract The evaluation and management of fluid balance are key challenges when caring for critically ill patients requiring renal replacement therapy. aim this study was to assess the ability clinical judgment other variables predict occurrence hypotension during intermittent hemodialysis (IHD) in patients. This a prospective, observational, single-center involving undergoing IHD. hypervolemia determined by managing nephrologists critical care physicians charge on basis data used calculate...
Abstract Background and Aims Acute kidney injury (AKI) diagnosis, management, the optimal prescription delivery of renal replacement therapy (RRT) standards for best practice are lacking. The aim this study was to explore clinical approach AKI RRT in a broad population Brazilian nephrologists. Method A cross-sectional survey distributed all nephrologists from multiple centres private hospital group. responses participants on several aspects management were analysed detailed. Results 97 (66%)...