Lucas Petri Damiani
A5033773108- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Bariatric Surgery and Outcomes
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Venous Thromboembolism Diagnosis and Management
- Body Composition Measurement Techniques
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
Instituto Dante Pazzanese de Cardiologia
2013-2025
Hospital do Coração
2016-2025
Brazilian Research in Intensive Care Network
2025
Hospital Israelita Albert Einstein
2022-2024
Hospital São Paulo
2014-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2021
Evidence (Italy)
2021
Estátikos (Brazil)
2021
Beneficência Portuguesa de São Paulo
2020
Santa Casa Hospital
2020
Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone might attenuate lung injury in these patients.
Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety efficacy of these therapies is limited.We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized suspected or confirmed Covid-19 who were receiving either no supplemental oxygen maximum 4 liters per minute oxygen. Patients randomly assigned in 1:1:1 ratio receive standard care, care plus...
The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.To determine if lung associated PEEP according to the best respiratory-system compliance decreases 28-day mortality moderate severe ARDS compared a conventional low-PEEP strategy.Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries November 17, 2011, through April 25,...
Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment as a target during in early not established.To determine if perfusion-targeted adults is more effective than lactate level-targeted for reducing mortality.Multicenter, randomized trial conducted at 28 intensive care units 5 countries. Four-hundred twenty-four patients were included between March 2017 2018. last date follow-up...
Abstract Objective To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial. Setting Nine hospitals in Brazil, 8 May to 17 July 2020. Participants Adults confirmed covid-19 who were receiving supplemental oxygen mechanical ventilation and had abnormal levels of at least two serum biomarkers (C reactive protein, D dimer, lactate dehydrogenase, ferritin). The data monitoring...
Background: Recent research efforts on bariatric surgery have focused metabolic and diabetes mellitus resolution. Randomized trials designed to assess the impact of in patients with obesity hypertension are needed. Methods: In this randomized, single-center, nonblinded trial, we included (using ≥2 medications at maximum doses or >2 moderate doses) a body mass index between 30.0 39.9 kg/m 2 . Patients were randomized Roux-en-Y gastric bypass plus medical therapy alone. The primary end...
<h3>Importance</h3> The effect of high-flow oxygen therapy vs conventional has not been established in the setting severe COVID-19. <h3>Objective</h3> To determine through a nasal cannula compared with on need for endotracheal intubation and clinical recovery <h3>Design, Setting, Participants</h3> Randomized, open-label trial conducted emergency intensive care units 3 hospitals Colombia. A total 220 adults respiratory distress ratio partial pressure arterial to fraction inspired less than...
The effects of rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve remain uncertain.
Rationale: A recent randomized controlled trial showed that a peripheral perfusion-guided resuscitation strategy was associated with lower mortality and less organ dysfunction when compared lactate-guided in patients septic shock, but the difference primary outcome, 28-day mortality, did not reach proposed statistical significance threshold (P = 0.06). We tested different analytic methods to aid interpretation of these results.Objectives: To reassess results ANDROMEDA-SHOCK using both...
<h3>Importance</h3> Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality acute kidney injury. <h3>Objective</h3> To determine the effect of a balanced solution vs saline (0.9% sodium chloride) on 90-day survival critically ill <h3>Design, Setting, Participants</h3> Double-blind, factorial, randomized clinical trial conducted at 75 ICUs...
<h3>Importance</h3> The effectiveness of checklists, daily goal assessments, and clinician prompts as quality improvement interventions in intensive care units (ICUs) is uncertain. <h3>Objective</h3> To determine whether a multifaceted intervention reduces the mortality critically ill adults. <h3>Design, Setting, Participants</h3> This study had 2 phases. Phase 1 was an observational to assess baseline data on work climate, processes, clinical outcomes, conducted between August 2013 March...
The well-being of patients undergoing chemotherapy treatment for colorectal cancer (CRC) is affected by psychological effects associated with treatment. However, little known about the impact these factors in Brazilian CRC.The aim this study was to determine whether perceived stress, social support, and resilience are quality life urban receiving CRC.This a cross-sectional conducted 144 CRC an ambulatory oncology clinic. participants completed 5 questionnaires: Demographics, Perceived Stress...
The effects of loading doses statins on clinical outcomes in patients with acute coronary syndrome (ACS) and planned invasive management remain uncertain.To determine if periprocedural atorvastatin decrease 30-day major adverse cardiovascular events (MACE) ACS management.Multicenter, double-blind, placebo-controlled, randomized trial conducted at 53 sites Brazil among 4191 evaluated angiography to proceed a percutaneous intervention (PCI) anatomically feasible. Enrollment occurred between...
To evaluate the prognostic value of phase angle (PA) obtained from bioelectrical impedance analysis (BIA) for mortality prediction in patients with cirrhosis.
Background: Midterm effects of bariatric surgery on patients with obesity and hypertension remain uncertain. Objective: To determine the 3-year Roux-en-Y gastric bypass (RYGB) blood pressure (BP) compared medical therapy (MT) alone. Design: Randomized clinical trial. (ClinicalTrials.gov: NCT01784848) Setting: Investigator-initiated study at Heart Hospital (HCor), São Paulo, Brazil. Participants: Patients receiving least 2 medications maximum doses or more than moderate a body mass index...
Rationale: The effects of balanced crystalloid versus saline on clinical outcomes for ICU patients may be modified by the type fluid that received initial resuscitation and admission. Objectives: To assess whether results a randomized controlled trial could affected use before enrollment admission type. Methods: Secondary post hoc analysis BaSICS (Balanced Solution in Intensive Care Study) trial, which compared solution (Plasma-Lyte 148) with 0.9% ICU. Patients were categorized according to...
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in patients with type diabetes, heart failure, and chronic kidney disease, but their effect on of critically ill organ failure is unknown.
The bleeding safety of ticagrelor in patients with ST-elevation myocardial infarction treated fibrinolytic therapy remains uncertain.