Letícia Kawano-Dourado
A5013915119- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Brucella: diagnosis, epidemiology, treatment
- Telomeres, Telomerase, and Senescence
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory viral infections research
- Rheumatoid Arthritis Research and Therapies
- Pulmonary Hypertension Research and Treatments
Hospital do Coração
2016-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2025
Universidade de São Paulo
2014-2024
Hospital São Paulo
2011-2024
Université Paris Cité
2021-2024
Pulmonary Associates
2024
Instituto do Coração
2024
Departamento de Epidemiología
2024
Inserm
2021-2022
Hôpital Bichat-Claude-Bernard
2022
Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone might attenuate lung injury in these patients.
Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety efficacy of these therapies is limited.We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized suspected or confirmed Covid-19 who were receiving either no supplemental oxygen maximum 4 liters per minute oxygen. Patients randomly assigned in 1:1:1 ratio receive standard care, care plus...
Abstract Updates This is the fourteenth version (thirteenth update) of living guideline, replacing earlier versions (available as data supplements). New recommendations will be published updates to this guideline. Clinical question What role drugs in treatment patients with covid-19? Context The evidence base for therapeutics covid-19 evolving numerous randomised controlled trials (RCTs) recently completed and underway. Emerging SARS-CoV-2 variants subvariants are changing therapeutics. new?...
Abstract Clinical question What is the role of drugs in preventing covid-19? Why does this matter? There widespread interest whether drug interventions can be used for prevention covid-19, but there uncertainty about which drugs, if any, are effective. Recommendations The second version living guideline reiterates previous strong recommendation against use hydroxychloroquine and includes a new conditional tixagevimab-cilgavimab individuals who do not have covid-19. How was created This from...
Background: Idiopathic pulmonary fibrosis (IPF) carries significant mortality and unpredictable progression, with limited therapeutic options. Designing trials patient-meaningful endpoints, enhancing the reliability interpretability of results, streamlining regulatory approval process are critical importance to advancing clinical care in IPF. Methods: A landmark in-person symposium June 2023 assembled 43 participants from US internationally, including patients IPF, investigators,...
Abstract Clinical question What is the role of remdesivir in treatment severe covid-19? This guideline was triggered by ACTT-1 trial published New England Journal Medicine on 22 May 2020. Current practice Remdesivir has received worldwide attention as a potentially effective for covid-19. After rapid market approval US, already being used clinical practice. Recommendations The panel makes weak recommendation use covid-19 while recommending continuation active enrolment patients into ongoing...
Background A usual interstitial pneumonia (UIP) pattern of lung injury is a key feature idiopathic pulmonary fibrosis (IPF) and also observed in up to 40% individuals with rheumatoid arthritis (RA)-associated disease (RA-ILD). The RA-UIP phenotype could result from either causal relationship RA on UIP or vice versa, simple co-occurrence IPF due shared demographic, genetic environmental risk factors. Methods We used two-sample bidirectional Mendelian randomisation (MR) test the hypothesis...
Background Fibrotic interstitial lung diseases (fILDs) are a heterogeneous group of associated with significant morbidity and mortality. Despite large increase in the number clinical trials last 10 years, current regulatory-approved management approaches limited to two therapies that prevent progression fibrosis. The drug development pipeline is long there an urgent need accelerate this process. This manuscript introduces concept design innovative research approach fILD: global Randomised...
Section:ChooseTop of pageAbstract <<Executive SummaryIntroductionMethodologyFindings/ResultsSummary and Future Direct...ReferencesCITING ARTICLES
Sex and gender differences influence key domains of research, lung health, healthcare access delivery. In interstitial diseases (ILDs), mouse models pulmonary fibrosis are clearly influenced by sex hormones. Additionally, short telomeres, a biomarker telomere regulation gene mutations, impacted sex, while heritability unexplained genetic variation may be attributable to gendered environmental factors that drive epigenetic control. Diseases like idiopathic fibrosis, hypersensitivity...
Early identification of patients with acute hypoxemic respiratory failure (AHRF) who are at risk failing high-flow nasal cannula (HFNC) therapy could facilitate closer monitoring, and timely adjustment/escalation treatment. We aimed to establish whether machine learning (ML) models predict HFNC outcome, early in the course treatment, greater accuracy than currently used clinical indices. developed ML trained using measurements made within first 2 h treatment from 184 AHRF (37% failures)...
Genetic analysis is emerging for interstitial lung diseases (ILDs); however, ILD practices are not yet standardized. We surveyed patients', relatives' and pulmonologists' experiences needs on genetic testing in to evaluate the current situation identify future needs.A clinical epidemiologist (MT) together with members of ERS taskforce representatives European Idiopathic Pulmonary Fibrosis related disorders Federation (EU-IPFF) patient organisation developed a survey patients, relatives...
Abstract Clinical question In adult patients with inflammatory bowel disease, arthritis (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis), or psoriasis taking biologic drugs, does proactive therapeutic drug monitoring (TDM) improve outcomes as compared standard care? Context and current practice Standard care for immune mediated diseases includes prescribing drugs at pre-determined doses. Dosing may be adjusted reactively, example increased disease activity. TDM, serum levels...
To establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung (SSc-ILD).A conceptual for subclinical, clinical and progressive ILD was provided to 83 experts, asking them use the classify actual SSc-ILD patients. Each patient profile designed be classified at least four terms of severity risk progression baseline; based on 1-year follow-up data. A consensus reached if ≥75% agreed. Experts information items were important determining...