A5075814128- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Extracellular vesicles in disease
- Genetic Neurodegenerative Diseases
- Psoriasis: Treatment and Pathogenesis
- RNA Research and Splicing
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lung Cancer Treatments and Mutations
Instituto Nacional de Enfermedades Respiratorias
2018-2023
Universidad Nacional Autónoma de México
2019
Interstitial Cystitis Association
2018
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that strongest risk factor for development of gain-of-function MUC5B promoter variant rs35705950, would also contribute to ILD among patients with RA.
Objective. To describe the evolution of pulmonary function in patients with interstitial lung disease (ILD) who are positive for at least 1 antisynthetase antibodies (ASAB) after medical treatment, and to compare whether is associated type ASAB. Methods. Patients ILD ASAB (anti-Jo1, anti-PL7, anti-PL12, anti-EJ, or anti-OJ) were included. The clinical evolution, time until death censoring, improvement registered. Results. study included 118 patients. Most had a high extent ground glass...
Anti-tRNA autoantibodies are associated with interstitial lung disease (ILD), in at least two clinical scenarios: the anti-synthetase syndrome (ASSD) and pneumonia autoimmune features (IPAF). Under pathological conditions, cytokines indicate participating elements course of inflammatory phenomena. We aimed to quantify serum concentrations different profiles patients anti-tRNA ILD (anti-tRNA-ILD) estimate association between these improvement progression. Serum levels 18 from baseline after...
The antisynthetase syndrome (ASSD) is an autoimmune disorder characterized by myositis, arthritis, mechanic's hands, fever, Raynaud phenomenon, and interstitial lung disease (ILD). We aimed to evaluate single-nucleotide polymorphisms in the interleukin 1B ( IL1B ) gene their association between ILD with autoantibodies, as well IL-1β serum levels. most frequent autoantibody was anti-Jo1. tomographic pattern non-specific pneumonia, whereas anti-Jo1 subjects, it organized pneumonia. Anti-Jo1...
Anti-synthetase syndrome (ASSD) is an autoimmune disorder characterized by inflammatory interstitial lung disease (ILD). The main objective of this work was to quantify the concentrations cytokines and molecules associated with inflammasome activation in bronchoalveolar lavage (BAL) patients ASSD a comparison group systemic sclerosis (SSc) patients. Cytokines lactate dehydrogenase (LDH) were determined using concentrated BAL protein. activity caspase-1 concentration NLRP3 protein purified...
Background: Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Its use has been associated with hypersensitivity pneumonitis and diffuse lung disease. Whether MTX exposure increases the risk of interstitial disease (ILD) in patients RA disputed. Objectives: We aimed to evaluate association antecedent development RA-ILD. Methods: Through case-control study design derivation international validation samples, we examined ILD 482 RA-ILD 741 without ILD. Estimates...
Antisynthetase syndrome (ASSD) is a rare multisystemic connective tissue disease affecting the skin, joints, muscles, and lungs, characterized by anti-aminoacyl transfer-RNA-synthetases (anti-tRNA) autoantibodies production, being anti-Jo1 most frequent. We included one-hundred twenty-one ASSD patients 340 healthy subjects (HS), also, we divided case group into non-anti-Jo1. Two single nucleotide polymorphisms (SNPs) in IL17A gene were evaluated. Anti-Jo1 was common anti-tRNA antibody our...
<h3>Background</h3> Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and idiopathic pulmonary fibrosis (IPF) share phenotypic similarities. The gain-of-function <i>MUC5B</i> promoter variant rs35705950 is the strongest risk factor for development of IPF <h3>Objectives</h3> We hypothesised that would also contribute to ILD in RA patients. <h3>Methods</h3> Using a French discovery population multi-ethnic validation populations from 6 different countries, we tested association...