A5000325687- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Cytokine Signaling Pathways and Interactions
- Salivary Gland Disorders and Functions
- Sarcoidosis and Beryllium Toxicity Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Vasculitis and related conditions
- Medical Imaging and Pathology Studies
- Galectins and Cancer Biology
- IgG4-Related and Inflammatory Diseases
- Pneumonia and Respiratory Infections
- Erythrocyte Function and Pathophysiology
- Psoriasis: Treatment and Pathogenesis
- Dermatological and Skeletal Disorders
- Chemokine receptors and signaling
- Heterotopic Ossification and Related Conditions
- Health Systems, Economic Evaluations, Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
National and Kapodistrian University of Athens
2011-2024
University General Hospital Attikon
2016-2023
Hospital Universitario Reina Sofía
2023
Center for Rheumatology
2017-2020
Instituto Nacional de Enfermedades Respiratorias
2018
Pulmonary Associates
2018
Sotiria General Hospital
2016
General Hospital of Athens G. Genimatas
2011
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that strongest risk factor for development of gain-of-function MUC5B promoter variant rs35705950, would also contribute to ILD among patients with RA.
Objective To identify independent contributors of fatigue in primary Sjögren's syndrome (SS) patients, taking into account clinical, laboratory, and psychological features, to explore the potential role interferon (IFN)–induced gene indoleamine 2,3‐dioxygenase (IDO‐1), anti–21‐hydroxylase (anti‐21[OH]) antibodies, soluble BAFF. Methods Detailed clinical laboratory characteristics were recorded for 106 SS patients. The Functional Assessment Chronic Illness Therapy–Fatigue, Zung Depression...
Objective This study aimed to analyse the phenotype of systemic lupus erythematosus (SLE) at first presentation and during follow-up in a newly established SLE cohort based ‘Attikon’ University Hospital. The hospital combines primary, secondary tertiary care for region Western Attica, Greece. Methods comprised mixed prevalent incident 555 Caucasian patients diagnosed with according American College Rheumatology 1997 criteria and/or Systemic Lupus Erythematosus International Collaborating...
Myositis associated interstitial lung disease (ILD) seems to be an under-recognized entity. In this multicenter, retrospective study, we recorded between 9/12/2019 and 30/9/2021 consecutive patients who presented in five different ILD centers from two European countries (Greece, France) received a multidisciplinary diagnosis of myositis associated-ILD. The primary outcome was all-cause mortality over 1 year specific subgroups patients. Secondary outcomes included comparison characteristics...
Interstitial pneumonia with autoimmune features (IPAF) refers to patients interstitial lung disease and not fulfilling the classification criteria for a specific connective tissue disease. We sought study characteristics, progression, response treatment complications of IPAF in 1-year follow-up period.Clinical laboratory findings, comorbidities, medications, pulmonary function tests (PFTs), chest HRCT during one-year period were documented each 39 enrolled IPAF.The mean age at time diagnosis...
clonal proliferation driving cryoglobulin production that may be quite independent of the viral trigger, which could suggest antiviral effect new DAAs should still combined with antiproliferative and immunomodulatory effects pegIFN for better outcomes.In conclusion, SVR to IFN-free therapy in HCV-MCV patients lead no clinical improvement.Thus, era optimal treatment remains determined.
Abstract Objectives RA and primary SS carry increased atherosclerotic risk, while B-cell activating factor holds a vital role in disease pathogenesis atherosclerosis. We aimed to compare subclinical atherosclerosis profiles between the two clinical entities define whether BAFF genetic variants alter risk. Methods DNA from 166 RA, 148 patients 200 healthy controls of similar age sex distribution was subjected PCR-based assay for detection five single nucleotide polymorphisms gene (rs1224141,...
<h3>Background:</h3> Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is one of the most common extra-articular manifestations RA, associated with high morbidity and mortality. Median survival after RA-ILD diagnosis varies among studies, but markedly reduced compared to RA patients without ILD general population. <h3>Objectives:</h3> To calculate mortality rate evaluate its association different radiographic patterns comorbidities in 'Attikon' cohort. <h3>Methods:</h3>...
Interstitial Lung Disease (ILD) represents one of the most severe complications Rheumatoid Arthritis (RA).Preliminary data from RA Greek cohort show a prevalence 5.3%.Due to scarcity data, little is known regarding epidemiological and clinical features patients with RA-ILD.Moreover, use pulmonary function tests for prognostic purposes in RA-ILD still not sufficiently studied.Interestingly, treatment approach remains controversial due high risk infection, possible drug-related toxicity,...
Abstract: As diffuse alveolar hemorrhage is defined the clinical pathological syndrome characterized by hemoptysis, infiltrates, acute respiratory failure and anemia. It a life-threatening condition medical emergency. Causes are multiple variable. A 75-year-old male, ex-smoker, with known coronary artery disease paroxysmal atrial fibrillation treated aspirin, presents due to low grade fever bloody sputum. Hemodynamically stable, without failure, but infiltrates on chest imaging Initially as...
Background: Psoriatic arthritis (PsA) affects both sexes equally, however there seem to be significant differences in disease expression between the genders. Objectives: To investigate gender manifestations, patient-reported outcomes and comorbidities among patients with PsA. Methods: This cross-sectional study of PsA followed at an academic rheumatology outpatient clinic 1/6/2017 1/12/2019. We compared clinical characteristics, outcomes, activity male female All were over 18 years age...
Background: Interstitial pneumonia with autoimmune features (IPAF) 1 describes a group of patients interstitial lung disease and who do not meet the classification criteria for specific connective tissue disease. Limited data regarding IPAF are available so far. Objectives: To identify epidemiological clinical characteristics to observe progression, response treatment frequency infections in 1-year follow-up period. Methods: Thirty-nine from ‘Attikon’ University Hospital Athens fulfilling...
Background: The lack of pathognomonic features poses a considerable challenge in SLE diagnosis. time from symptom onset to diagnosis has been reported range two six years 1 . Objectives: To document the initial symptoms disease and lapse until its Methods: We examined 438 patients “Attikon” cohort 2 For diagnosis, we used classification criteria (ACR, SLICC, EULAR-ACR) or few cases clinical (n=32, 7.3%). Data were collected using patient interviews, in-person visits medical charts review....
Background: Systemic Lupus Erythematosus (SLE) can first present with severe or critical disease leading to hospitalization. Prompt recognition of the in hospitalized patients may lead early institution treatment and improve outcomes. We have recently developed a clinician-friendly algorithm for SLE diagnosis based on classical clinical serological features [SLE Risk Probability Index (SLERPI)] 1 . Objectives: To determine phenotype diagnosed during hospitalization, interval between...
<h3>Background</h3> Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of ANCA-associated vasculitis in which it frequently difficult to achieve glucocorticoid (GC) tapering without relapse. Mepolizumab (MEPO) an approved anti-IL5 agent for EGPA but real-world evidence its long-term efficacy and survival scarce. <h3>Objectives</h3> To study the efficacy, safety, MEPO daily clinical practice. <h3>Methods</h3> Retrospective all patients who received two academic Rheumatology...
<h3>Background</h3> Despite recent advances in the management of rheumatic diseases with emergence new targeted therapies, treatment options remain limited systemic lupus erythematosus (SLE) [1] and disease may be refractory to conventional treatment. <h3>Objectives</h3> To evaluate off-label use biologics a large cohort patients, its safety efficacy. <h3>Methods</h3> Retrospective analysis Attikon SLE comprising over 800 patients total order identify receiving therapies. Indication...
<h3>Background</h3> The attribution of neuropsychiatric manifestations to systemic lupus erythematosus (SLE) or unrelated causes is often obscure. <h3>Objectives</h3> events (SLE related) other (non-SLE in a large SLE cohort. <h3>Methods</h3> Retrospective study 707 patients from "Attikon" cohort <sup>[1,2]</sup>. Neuropsychiatric were classified as either primary related; attributed using combination multidisciplinary physician judgment with models <sup>[3]</sup>) secondary NPSLE not SLE)...
<h3>Background</h3> Recent data highlight the increased risk for premature atherosclerosis in primary Sjogren's syndrome (pSS) patients. Given a potential role of B cells atherosclerotic plaque formation, we explored contribution B-cell activating factor (BAFF) pSS-related atherosclerosis. <h3>Materials and methods</h3> 72 patients, fulfilling ACR/EULAR criteria pSS, with detailed clinical, laboratory histopathological regarding both pSS traditional factors underwent carotid femoral arteries...