A5082976918- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Psoriasis: Treatment and Pathogenesis
- Retinal and Optic Conditions
- Autoimmune Bullous Skin Diseases
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Peripheral Neuropathies and Disorders
- Autoimmune and Inflammatory Disorders Research
- Liver Diseases and Immunity
- Health Systems, Economic Evaluations, Quality of Life
- Galectins and Cancer Biology
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Pharmaceutical studies and practices
National and Kapodistrian University of Athens
2020-2025
University General Hospital Attikon
2020-2024
Aristotle University of Thessaloniki
2024
Hospital Universitario Reina Sofía
2023
Biomedical Research Foundation of the Academy of Athens
2022
Center for Rheumatology
2020
Systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS) represents a challenging SLE endotype whose molecular basis remains unknown.
Objective This study aimed to analyse the phenotype of systemic lupus erythematosus (SLE) at first presentation and during follow-up in a newly established SLE cohort based ‘Attikon’ University Hospital. The hospital combines primary, secondary tertiary care for region Western Attica, Greece. Methods comprised mixed prevalent incident 555 Caucasian patients diagnosed with according American College Rheumatology 1997 criteria and/or Systemic Lupus Erythematosus International Collaborating...
Objectives: Vaccination against SARS-CoV-2 has been vital in alleviating the spread of recent pandemic. We aimed to estimate frequency and type adverse events related vaccine patients with lupus nephritis (LN), assess its impact, if any, on risk subsequent reactivation nephritis. Methods: This was a retrospective, multicenter study which included biopsy-proven LN, who had received at least one dose. Patients ended up end-stage kidney disease (ESKD) prior vaccination or were diagnosed LN...
Objective Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterised by variable treatment responses. We investigated the transcriptional landscape associated with response and resistance in SLE. Methods Blood was collected from 92 active patients SLE at baseline after 6 months (n=32 paired samples) of cyclophosphamide (n=40), rituximab (n=20), belimumab (n=23), mycophenolate mofetil (n=8) or azathioprine (n=1) subjected to RNA sequencing. The defined Lupus Low...
Objective Changes in the care of patients with SLE dictate a re-evaluation its natural history and risk factors for disease deterioration damage accrual. We sought to decipher predictive phenotype (‘transition’) initially presenting non-severe disease. Methods Patients from ‘Attikon’ cohort duration ≥1 year were included. Disease at diagnosis was categorised as mild, moderate or severe, based on British Isles Lupus Assessment Group manifestations physician judgement. ‘Transition’ severity...
An interplay between immune cells and resident skin joint stromal is implicated in psoriatic arthritis (PsA), yet the mechanisms remain elusive with a paucity of molecular biomarkers for activity response. Combined transcriptomic immunophenotypic analysis whole blood fibroblasts could provide further insights. Whole RNA-seq was performed longitudinally 30 subjects PsA at beginning, one six months after treatment, response defined months. As control groups, 10 healthy individuals rheumatoid...
A blood-based biomarker is needed to assess lupus nephritis (LN) disease activity, minimizing the need for invasive kidney biopsies. Long non-coding RNAs (lncRNAs) are known regulate gene expression, appear be stable in human plasma, and can serve as non-invasive biomarkers.Transcriptomic data of whole blood samples from 74 LN patients 20 healthy subjects (HC) were analyzed identify differentially expressed (DE) lncRNAs associated with quiescent flares. Weighted co-expression network...
Interstitial pneumonia with autoimmune features (IPAF) refers to patients interstitial lung disease and not fulfilling the classification criteria for a specific connective tissue disease. We sought study characteristics, progression, response treatment complications of IPAF in 1-year follow-up period.Clinical laboratory findings, comorbidities, medications, pulmonary function tests (PFTs), chest HRCT during one-year period were documented each 39 enrolled IPAF.The mean age at time diagnosis...
<h3>Objective</h3> To evaluate the efficacy of anifrolumab (ANI) in refractory cutaneous manifestations systemic lupus erythematosus (SLE) real-world settings. <h3>Methods</h3> Patients with SLE, according to ACR 1997 criteria and/or SLICC 2012 criteria, and who received were included. Demographic clinical characteristics laboratory values documented at baseline last visit follow-up. Prior use immunosuppressives glucocorticoids, as well adverse events also recorded. SLE disease activity was...
Objective Skin involvement is common in systemic lupus erythematosus (SLE), but may be resistant to conventional treatment. We sought evaluate the efficacy of anifrolumab (ANI) refractory cutaneous manifestations SLE. Methods Case series patients with SLE from three Rheumatology Departments Greece. Outcome measures were improvement Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), physician global assessment (PGA) and Cutaneous Area Severity (CLASI). Clinically relevant...
<h3>Objective</h3> To discern predictive factors for the development of incident lupus nephritis (LN) in systemic erythematosus (SLE) patients. <h3>Methods</h3> Patients with SLE, according to American College Rheumatology 1997 criteria and/or Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) 2012 criteria, from a mixed prevalent and cohort ('Attikon' cohort) were followed biopsy-proven nephritis. Demographics, clinical characteristics laboratory values at baseline...
Abstract Objectives To discern predictive factors for incident kidney involvement in patients with SLE. Methods Patients SLE from the ‘Attikon’ Lupus cohort were monitored LN, defined by histology and/or classification criteria. Demographic and clinical characteristics at baseline compared against who did not develop LN. LN-free Kaplan–Meier survival curves generated. A multivariate Cox proportional hazards model was used to identify independent predictors of Independent validation performed...
<h3>Background:</h3> Systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS) represents one of the most challenging endotypes SLE, yet its distinctive molecular basis from non-APS SLE remains elusive. <h3>Objectives:</h3> To comprehensively profile blood transcriptome a large cohort patients who had APS or tested positive for aPL, to advance our understanding and introduce novel therapeutic interventions. <h3>Methods:</h3> We analyzed whole RNA-sequencing data 299 (108...
Active immunization against SARS-CoV-2 has been a critical mitigation tool during the pandemic.1,S1,S2 Patients with glomerular diseases (GDs) are at risk for severe illness caused by SARS-CoV-2, due to impaired kidney function and long-standing immunosuppressive therapy. Therefore, vaccination is of high importance these patients. However, multiple reports have described new onset or relapse GDs following vaccination, although details clinical characteristics vaccine-associated GD...
<h3>Background</h3> Anifrolumab (ANI) a human monoclonal antibody to type I interferon receptor subunit 1 has been recently approved for the treatment of SLE. In SLE, skin is not only target but also key- driver autoimmune response via production IFN. <h3>Objectives</h3> To evaluate efficacy ANI in real-life under early access program (09/2021 – 03.2022). <h3>Methods</h3> A total seven patients (all female, mean age 50 years, disease duration 15 years) with SLE- diagnosis based on ACR1997 or...
Background: Psoriatic arthritis (PsA) affects both sexes equally, however there seem to be significant differences in disease expression between the genders. Objectives: To investigate gender manifestations, patient-reported outcomes and comorbidities among patients with PsA. Methods: This cross-sectional study of PsA followed at an academic rheumatology outpatient clinic 1/6/2017 1/12/2019. We compared clinical characteristics, outcomes, activity male female All were over 18 years age...
Background: Interstitial pneumonia with autoimmune features (IPAF) 1 describes a group of patients interstitial lung disease and who do not meet the classification criteria for specific connective tissue disease. Limited data regarding IPAF are available so far. Objectives: To identify epidemiological clinical characteristics to observe progression, response treatment frequency infections in 1-year follow-up period. Methods: Thirty-nine from ‘Attikon’ University Hospital Athens fulfilling...
Background: The lack of pathognomonic features poses a considerable challenge in SLE diagnosis. time from symptom onset to diagnosis has been reported range two six years 1 . Objectives: To document the initial symptoms disease and lapse until its Methods: We examined 438 patients “Attikon” cohort 2 For diagnosis, we used classification criteria (ACR, SLICC, EULAR-ACR) or few cases clinical (n=32, 7.3%). Data were collected using patient interviews, in-person visits medical charts review....
Background: Systemic Lupus Erythematosus (SLE) can first present with severe or critical disease leading to hospitalization. Prompt recognition of the in hospitalized patients may lead early institution treatment and improve outcomes. We have recently developed a clinician-friendly algorithm for SLE diagnosis based on classical clinical serological features [SLE Risk Probability Index (SLERPI)] 1 . Objectives: To determine phenotype diagnosed during hospitalization, interval between...