A5057163448- Gastric Cancer Management and Outcomes
- Plant chemical constituents analysis
- Synthesis of Organic Compounds
- Metastasis and carcinoma case studies
- Chemical synthesis and alkaloids
- Bioactive natural compounds
- Traditional and Medicinal Uses of Annonaceae
- Neurotransmitter Receptor Influence on Behavior
- Phytochemical compounds biological activities
- Receptor Mechanisms and Signaling
- Synthesis and Biological Activity
- Gastrointestinal Tumor Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Treatments and Studies
- Neuroscience and Neuropharmacology Research
- Rheumatoid Arthritis Research and Therapies
- Analytical Chemistry and Chromatography
- Fungal Plant Pathogen Control
- Advanced MIMO Systems Optimization
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Pharmacological Receptor Mechanisms and Effects
- Systemic Lupus Erythematosus Research
- Phytochemistry and Biological Activities
Kindai University
1998-2024
Tokyo National Hospital
1998-2024
National Sagamihara Hospital
2015-2024
Kyushu University
2013-2024
Aichi Medical University
2018-2024
Aichi Medical University Hospital
2021-2024
University of Tsukuba
2012-2023
Center for Rheumatology
2023
Kawasaki Medical School
2013-2021
Suita Tokushukai Hospital
2020
The first planned interim analysis (median follow-up, 3 years) of the Adjuvant Chemotherapy Trial S-1 for Gastric Cancer confirmed that oral fluoropyrimidine derivative significantly improved overall survival, primary end point. results were therefore opened at recommendation an independent data and safety monitoring committee. We report 5-year follow-up on patients enrolled onto ACTS-GC study.Patients with histologically stage II or III gastric cancer who underwent gastrectomy D2...
Natural killer (NK) cells express inhibitory and activation receptors that recognize MHC class I-like molecules on target cells. These may be involved in the critical role of NK controlling initial phases certain viral infections. Indeed, Ly49H cell receptor confers vivo genetic resistance to murine cytomegalovirus (MCMV) infections, but its ligand was previously unknown. Herein, we use heterologous reporter demonstrate recognizes MCMV-infected a encoded by MCMV itself. Exploiting...
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that strongest risk factor for development of gain-of-function MUC5B promoter variant rs35705950, would also contribute to ILD among patients with RA.
We performed a retrospective review of 59 pancreatic resections for ductal carcinoma the pancreas head between 1971 and 1983. In addition to pancreaticoduodenectomy, 37 consecutive patients (from 1981) received lymphatic dissection adjacent (Group R1), whereas another 22 1981 1983) wider range soft tissue dissection, including para-aortic region R2). These groups did not differ with regard operative mortality rate or background factors in who tolerated operation. The 3-year cumulative...
In Brief Objective: The aims of this prospective study were to investigate the true incidence portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy using contrast-enhanced computed tomography (CT) scan, and outcome anticoagulant therapy for PSVT. Summary Background Data: Although rare, venous system is considered a possible cause death splenectomy. reported ultrasonographically detected PSVT open ranges from 6.3% 10%. Methods: Twenty-two patients underwent (LS...
This article reports on a new approach to hepatic arterial chemoembolization therapy using ethiodized oil (Lipiodol, Ultra Fluide), cisplatin, and gelatin sponge (Gelfoam, Upjohn, Kalamazoo, MI) for hepatocellular carcinoma (HCC). The anticancer effects of this 20 patients who underwent subsequent resection were evaluated mainly by histologic examination. All main tumors reduced in size following therapy. It is notable that 65% the tumor was less than 50% before values serum α-fetoprotein...
Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease that prevalent in populations. While it considered rare the rest of world, significant number FMF patients have been reported East Asia, including Japan. Our aim was to determine prevalence Japan and elucidate clinical genetic features Japanese patients. A primary nationwide survey conducted between January December 2009. Hospitals specializing pediatrics hospitals with pediatric, internal medicine,...
Objective. Recent advances in the management of patients with rheumatoid arthritis (RA) increased rates disease remission and patient life expectancy, while malignancy has become a more common cause death. Here, we report incidence nationwide survey Japanese RA compared to general population, focusing on risk lymphoma, which often arises RA. Methods. Data occurrence were collected from registered cohort database, National Database Rheumatic Diseases by iR-net Japan, 2003 2012. To adjust for...
Murrayaquinone A (1) and murrayafoline (3), isolated from the root bark of Murraya euchrestifolia, were identified as cytotoxic compounds. demonstrated significant cytotoxicity against SK-MEL-5 Colo-205 cells, with ED(50) values 2.58 3.85 microg/mL, respectively. In contrast, (3) exhibited marginal or weak SK-MEL-5, Colo-205, HCT-8, KB, A-549 tumor cell lines, ranging 5.31 to 7.52 microg/mL. total, 20 carbazole alkaloids (1-20), previously by Furukawa et al. various plant sources also...
Recognition of metastatic tumor cells with distinct biochemical phenotypes predominant in the primary tumors should be useful not only for establishment new therapeutic approaches but also identification high-risk or low-risk patients relapse. We examined whether carbohydrate antigens, sialyl Lewis(x) (sLe(x)) and Lewis(a) (sLe(a)) are involved colorectal cancer metastasis.Metastatic abilities human colon cell variants that were selected their high low surface levels sLe(x) (KM12-HX KM12-LX,...
Several natural products have been found to anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were significantly inhibit EBV-EA preserved high...
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by MEditerranean FeVer gene (MEFV) mutations. In Japan, patients with FMF have been previously reported, including a mild or incomplete form. Several factors are presumed to contribute the variable penetrance and phenotypic variability of FMF. We conducted current study investigate correlation clinical presentations MEFV genotypic distributions in Japanese patients. analyzed demographic, clinical, genetic data for 311...
Introduction Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association RA have been reported, but few validated in an subpopulation ILD. In this study, we investigated the HLA class II alleles ILD RA. Methods An study was conducted on HLA-DRB1, DQB1, and DPB1 450 Japanese patients that were or not diagnosed ILD, based findings computed tomography images...
Epicardial fat (EF) is the visceral of heart deposited under layer pericardium and has same origin as abdominal fat, which shown to be strongly related development coronary artery disease (CAD). We measured volume EF (EFV) by 64-multidetector computed tomography (MDCT) studied relationship between EFV severity CAD.Epicardial increases steeply in patients with significant stenosis those severe calcification.We 197 suspected CAD who underwent 64-MDCT angiography. Cross-sectional tomographic...
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other may negatively associated. However, studies on latter rare. Here, we focus protective effects DRB1 in Japanese patients an association study. Relative predispositional (RPE) were analyzed by sequential elimination carriers each allele strongest association. The investigated...
Leaf flavonoids were quantitatively determined in 68 representative or economically important Citrus species, cultivars, and near-Citrus relatives. Contents of 23 including 6 polymethoxylated flavones analyzed by means reversed phase HPLC analysis. Principal component analysis revealed that the 7 associations according to Tanaka's classification observed, but some do overlap each other. Group VII species could be divided into two different subgroups, namely, first-10-species class...