A5027753891- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Plant Pathogens and Fungal Diseases
- Indoor Air Quality and Microbial Exposure
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational exposure and asthma
- Congenital Anomalies and Fetal Surgery
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Infectious Diseases and Mycology
- Amoebic Infections and Treatments
- Nail Diseases and Treatments
- Malaria Research and Control
- Mycotoxins in Agriculture and Food
- Infectious Diseases and Tuberculosis
- Fungal Biology and Applications
- Mosquito-borne diseases and control
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Transplantation: Methods and Outcomes
- Urticaria and Related Conditions
- Cystic Fibrosis Research Advances
Centre Hospitalier Universitaire de Besançon
2016-2025
Laboratoire Chrono-Environnement
2015-2024
Centre National de la Recherche Scientifique
2012-2024
Université de franche-comté
2010-2024
Centre Hospitalier Andrée Rosemon
2024
Groupe Clarins (France)
2023
University of Bern
2020
University of Hohenheim
2020
Administración Nacional de Laboratorios e Institutos de Salud
2020
University of Salford
2020
Abstract Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such inflammatory bowel disease and irritable syndrome, or infections by diverse enteric pathogens. Blastocystis is one most common single-celled eukaryotes detected human faecal samples. However, clinical significance this widespread colonization remains unclear, its pathogenic potential controversial. To address issue pathogenicity,...
Echinococcoses require the involvement of specialists from nearly all disciplines; standardization terminology used in field is thus crucial. To harmonize echinococcosis on sound scientific and linguistic grounds, World Association Echinococcosis launched a Formal Consensus process. Under coordination Steering Writing Group (SWG), Consultation Rating (CRG) had main missions (1) providing input list terms drafted by SWG, taking into account available literature participants' experience; (2)...
Background. The aim of our study was to assess the detection circulating DNA from most common species Mucorales for early diagnosis mucormycosis in at-risk patients. Methods. We retrospectively evaluated a combination 3 quantitative polymerase chain reaction (qPCR) assays using hydrolysis probes targeting Mucor/Rhizopus, Lichtheimia (formerly Absidia), and Rhizomucor detection. Serial serum samples 10 patients diagnosed with proven (2–9 per patient) were analyzed. Results. No...
Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence CAPA patients with intensive care units (ICU) and investigate risk factors for well outcome.The European Confederation Medical Mycology (ECMM) conducted including 20 centres from nine countries assess epidemiology, outcome CAPA. was defined according 2020 ECMM/ISHAM...
Early diagnosis and prompt initiation of specific antifungal treatment are essential for improving the prognosis mucormycosis. We aimed to assess performance serum Mucorales quantitative polymerase chain reaction (qPCR) early follow-up mucormycosis.We prospectively enrolled 232 patients with suspicion invasive mold disease, evaluated using standard imaging mycological procedures. Thirteen additional proven or probable mucormycosis were included analyze DNA load kinetics. Serum samples...
Blastocystis sp. is the most common intestinal parasite of humans. Despite its potential public health impact, epidemiological data regarding prevalence and molecular subtype distribution in Europe are rarely reported. Therefore, first multi-center survey performed was conducted France to diagnose identify risk factors for infection. Stool samples from 788 patients were collected either summer or winter 11 hospitals throughout together with patient data. All stool tested presence by...
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Abstract Our prospective case–control study of 118 dwellings in Eastern France examined fungal contamination unhealthy (n = 32) (homes with visible mold and adverse health outcomes reported by the occupants), occupied allergic patients (with medical diagnostic positive prick-tests for molds) 27) matched control 59). Unhealthy present higher airborne concentrations Aspergillus, Penicillium, Cladosporium than dwellings, irrespective room sampled. Bedroom walls were more highly contaminated...
Summary The growth potential of the tumour‐like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE ) is directly dependent upon nature/function periparasitic adaptive host immune‐mediated processes. PD ‐1/ ‐L1 pathway (programmed cell death 1), which inhibits lymphocytic proliferation in tumour development, over‐expressed at chronic stage . We tested impact a blockade on outcome both (intraperitoneal inoculation, secondary and SAE acute (peroral egg infection,...
The aim of this study was to evaluate diagnostic means, host factors, delay occurrence, and outcome patients with COVID-19 pneumonia fungal coinfections in the intensive care unit (ICU). From 1 February 31 May 2020, we anonymously recorded COVID-19-associated pulmonary aspergillosis (CAPA), fungemia (CA-fungemia), pneumocystosis (CA-PCP) from 36 centers, including results on biomarkers respiratory specimens serum. We collected data 154 episodes CAPA, 81 CA-fungemia, 17 CA-PCP, 5 other mold...
Abstract Background The classification of invasive pulmonary aspergillosis (IPA) issued by the European Organization for Research and Treatment Cancer/Mycoses Study Group Education Consortium (EORTC/MSGERC) is used immunocompromised patients. An alternative algorithm adapted to intensive care unit (ICU) population has been proposed (AspICU), but this did not include microbial biomarkers such as galactomannan antigen Aspergillus quantitative PCR. objective present pilot study was evaluate a...
Abstract Our objective was to determine whether the twice-weekly screening of high-risk hematology patients by Mucorales qPCR on serum affects prognosis mucormycosis. Results from all tests performed unit January 2017 December 2022 were analyzed. Patients with positive results classified as having proven, probable or ‘PCR-only’ One-month mortality for local cohort compared that a national cases mucormycosis collected French surveillance network invasive fungal disease (‘Réseau de...
Tinea capitis (TC) is still a frequent dermatophytosis in France, both autochthonous and imported. A nationwide retrospective survey was performed total of 4395 TC cases were recorded within 36 French mycology laboratories during 6-year period. disease that occurs childhood with 85% the occurring before 10 years old 94% age 15. Anthropophilic origin predominant 779 Trichophyton tonsurans (32.6%), 738 soudanense/T. violaceum (31%), 445 Microsporum audouinii (19.2%). Of note, T. represents...
Abstract Background While invasive fusariosis and lomentosporiosis are known to be associated with fungemia, overall data on mold-related fungemia limited, hampering early management. This study aimed describe the epidemiology of mold-positive blood cultures. Methods Epidemiological clinical cultures from 2012 2022 were obtained RESSIF database. Pseudofungemia was excluded using modified Duthie Denning criteria. Univariable multivariable Firth logistical regression used factors 90-day...
Inhalation of conidia is the main cause invasive pulmonary aspergillosis (IPA) and respiratory epithelium first line defence. To explore triggering factor for inflammatory response to Aspergillus fumigatus , species mainly responsible IPA, this study analysed differential expression three genes in A549 cells after challenge with live killed conidia. The influence steroids, one risk factors developing was also investigated. Quantification mRNAs mediator encoding interleukin (IL)-8, tumour...
Dwellings showing a presence of moulds are considered to be unhealthy both by the inhabitants and sanitary authorities. Although thresholds pathogenicity have not yet been established, toxic, allergic infectious risk indoor is better understood today. A study on fungi contamination for 128 dwellings was done between October May in France. It concerned 69 dwellings, occupants which either complained authorities about problems humidity or consulted doctor who related their symptoms housing...
The aim of our study was to compare, using real-time (Rt) PCR, quantitative levels five fungal species in three kinds dwellings.Three groups homes were recruited: moisture-damaged (MDH, n = 30), allergic patient (APH, 25) and paired control (CH, 55). Five moulds with allergenic compounds or mycotoxin production characteristics (Cladosporium sphaerospermum, Penicillium chrysogenum, Aspergillus versicolor, Alternaria alternata Stachybotrys chartarum) quantified Rt-PCR. Cycle threshold results...
We studied COVID-19 associated mucormycosis based on 17 cases reported nationwide and assessed the differences with India. They differed by frequencies of diabetes mellitus (47% in France versus up to 95% India), hematological malignancies (35% 1%), anatomical sites (12% >80% rhino-orbito-cerebral) prognosis (88% mortality <50%).
Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) immune checkpoint blockade are efficacious in certain cancer therapies.The present study aimed to provide a picture about the development of innate adaptive responses upon PD-L1 treating chronic murine AE.Immune treatment started at 6 weeks post-E. multilocularis infection, was maintained for 8 with twice per week anti-PD-L1 administration (intraperitoneal). The included an outgroup-control mice perorally medicated albendazole 5...
The mite Dermanyssus gallinae may cause pruritic dermatitis in humans. We describe a case of nosocomial infestation with D. from an abandoned pigeon nest suspended on the front wall Hôpital Henri Mondor near window. Close surveillance and regular destruction nests could prevent these incidents infection
A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where non-genetically related A. isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned agricultural areas.