Marjorie Cornu
A5020667743- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Cystic Fibrosis Research Advances
- Antibiotic Use and Resistance
- Inflammatory Bowel Disease
- Mycotoxins in Agriculture and Food
- Neonatal and Maternal Infections
- Toxoplasma gondii Research Studies
- Nosocomial Infections in ICU
- Dermatological diseases and infestations
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
- Bacterial Identification and Susceptibility Testing
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Infectious Diseases and Mycology
- Leprosy Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Coccidia and coccidiosis research
- Water management and technologies
- Neonatal skin health care
- Insects and Parasite Interactions
Unité de Glycobiologie Structurale et Fonctionnelle
2020-2024
Université de Lille
2017-2024
Inserm
2016-2024
Institut de Biologie de Lille
2022-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Centre National de la Recherche Scientifique
2020-2023
Centre Hospitalier Universitaire de Lille
2015-2023
Institut Pasteur
1978-2023
Université de Caen Normandie
2023
Lille’s Cardiology Hospital
2015-2022
Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large study has compared the incidence of IPA between and influenza patients.To determine putative in critically ill SARS-CoV-2 patients, with patients.This was planned ancillary analysis coVAPid retrospective European cohort. Consecutive adult patients requiring mechanical ventilation > 48 h pneumonia or were included. The 28-day cumulative IPA, based on Blot definition,...
Laboratory diagnosis of histoplasmosis is based on various methods, including microscopy, culture, antigen, and DNA detection Histoplasma capsulatum var. or duboisii. To improve sensitivity existing real-time quantitative PCR (qPCR) assays, we developed a new RT-qPCR assay that allows amplification whole nucleic acids spp. validated suspected cases. The limit was 20 copies, the specificity against 114 fungal isolates/species restricted to Whole 1319 prospectively collected consecutive...
Abstract Interlaboratory evaluations of Mucorales qPCR assays were developed to assess the reproducibility and performance methods currently used. The participants comprised 12 laboratories from French university hospitals (nine them participating in Modimucor study) 11 Fungal PCR Initiative. For panel 1, three sera each spiked with DNA different species (Rhizomucor pusillus, Lichtheimia corymbifera, Rhizopus oryzae). 2, six concentrations R. pusillus L. corymbifera (1, 10, 100 genomes/ml)...
Introduction: The diagnosis of neonatal invasive Candida infections (ICIs) is problematic because the clinical signs are not specific and blood cultures rarely positive. Hence, new diagnostic markers needed. Objective: To assess contribution serum (1–3)-β-d-glucan (BDG) levels to ICIs analyse change in this parameter during antifungal therapy. Methods: This retrospective study (December 2010-March 2012) was performed at Amiens University Medical Center (Amiens, France). We included newborns...
We recently developed a mass spectrometry (MS) procedure based on the detection of serum disaccharide (MS-DS) in patients with invasive candidiasis (IC). Here, we compare performance MS-DS for diagnosis IC, aspergillosis (IA), and mucormycosis (MM) those commercially available antigen tests. This retrospective study included 48 (23 IC [74 samples], 15 IA [40 10 MM [15 samples]) 49 appropriate controls (102 samples). MS-DS, mannan (Mnn), galactomannan (GM), (1,3)-β-d-glucan (BDG) were...
We studied COVID-19 associated mucormycosis based on 17 cases reported nationwide and assessed the differences with India. They differed by frequencies of diabetes mellitus (47% in France versus up to 95% India), hematological malignancies (35% 1%), anatomical sites (12% >80% rhino-orbito-cerebral) prognosis (88% mortality <50%).
Most newborns in the neonatal intensive care unit (NICU) are premature and at risk of invasive fungal infections (IFIs). Invasive yeast (IYIs) most common this population. These difficult to diagnose because symptoms nonspecific, sensitivity blood cultures is low. The serum (1,3)-β-D-glucan (BDG) assay provides a reliable marker for diagnosis IFIs adults with haematological malignancies. We assessed diagnostic performance test IYIs its contribution monitoring antifungal treatment. A...
Objective— Cardiovascular diseases constitute the leading cause of mortality worldwide. Calcification vessel wall is associated with cardiovascular morbidity and in patients having many diseases, including diabetes mellitus, atherosclerosis, chronic kidney disease. Vascular calcification actively regulated by inductive inhibitory mechanisms (including vascular smooth muscle cell adaptation) results from an active osteogenic process. During process, extracellular vesicles (also known as...
The use of isavuconazole is approved for the management invasive aspergillosis and mucormycosis, only in adults, as no paediatric pharmacology studies have been reported to date. Very few cases published concerning isavuconazole. Amphotericin B antifungal agent recommended but adverse effects especially nephrotoxicity, even with liposomal formulation, could be problematic. In this context, other molecules active on Mucorales becomes needful. We describe a case mucormycosis rapid onset...
Fusarium spp. are plant pathogens and opportunistic in severely immunocompromised (hematological malignancy, neutropenia, solid organ transplantation, etc.) burned patients. Invasive fusariosis often disseminates mortality remains high partly due to delayed diagnosis the absence of a positive culture. The aim our study is design quantitative PCR (qPCR) assay evaluate detection DNA for early invasive infection. A qPCR was designed optimized identify all species complex secondarily evaluated...
Antifungal treatment is common in critically ill patients, but only a small proportion of patients receiving antifungals have proven fungal infection. However, antifungal has side effects such as toxicity, emergence resistance, and high cost. Moreover, empirical still matter for debate these patients. Our study aimed to determine the incidence, associated factors, safety de-escalation patients.This retrospective was conducted 30-bed mixed ICU, from January 2012 through 2013. Patients...
A mass spectrometry (MS) method that detects a serum disaccharide (DS) (MS-DS) was recently described for the diagnosis of invasive fungal infections (IFI). We carried out European collaborative study to evaluate this assay.
Abstract Background Intestinal fibrosis is a frequent complication of Crohn’s disease. However, the factors that cause chronicity and promote fibrogenesis are not yet understood. Aims In present study, we evaluated profibrotic effects adherent-invasive Escherichia coli (AIEC) LF82 strain Candida albicans in gut. Methods Colonic was induced C57BL/6 mice by administration three cycles 2.5% (w/v) dextran sulfate sodium (DSS) for 5 weeks. C. were administered orally once at start each week or...
Due to large outbreaks observed worldwide, Candida auris has emerged as a major threat healthcare facilities. To prevent these phenomena, systematic screening should be performed in patients transferred from regions where the pathogen is highly endemic. In this study, we recorded and analyzed French mycologists' current knowledge practice regarding C. diagnosis. Thirty-six centers answered an online questionnaire. Only 11 (30.6 %) participants were aware of any for admitted their hospital....
ABSTRACT The aim of this study was to identify parameters influencing DNA extraction and PCR amplification efficiencies in an attempt standardize Mucorales qPCR. Fungal Initiative Laboratory Working Group distributed two panels simulated samples 26 laboratories: Panel A (six sera spiked with one negative control serum) B extracts). underwent each laboratory according the local procedure were sent a central for testing using three different qPCR techniques: in-house assay commercial assays...