A5086983388- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- Global Maternal and Child Health
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Long-Term Effects of COVID-19
- Global Health and Surgery
- Whipple's Disease and Interleukins
- Immune responses and vaccinations
- Anesthesia and Pain Management
- Hormonal and reproductive studies
- Global Health Workforce Issues
- Muscle and Compartmental Disorders
- Tuberculosis Research and Epidemiology
- Myasthenia Gravis and Thymoma
- Sexual Differentiation and Disorders
- Cancer Immunotherapy and Biomarkers
- Pituitary Gland Disorders and Treatments
- Travel-related health issues
- Delphi Technique in Research
- Dental Anxiety and Anesthesia Techniques
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- HIV-related health complications and treatments
Ospedale Sacro Cuore Don Calabria
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
University of Verona
2022
University of Modena and Reggio Emilia
2012
IRCCS Istituto Auxologico Italiano
2009
University Hospital Frankfurt
1966
Goethe University Frankfurt
1966
Background The host immune response has a prominent role in the progression and outcome of SARS-CoV-2 infection. Lymphopenia been described as an important feature infection associated with severe disease manifestation. Lymphocyte dysregulation hyper-inflammation have shown to be more clinical course; however, T cell subpopulation whose dysfunction correlate yet identify. Methods We performed immuno-phenotypic analysis sub-populations peripheral blood from patients affected by different...
MRI is the preferred imaging technique for identification of osteomyelitis. The key element diagnosis presence bone marrow edema (BME). Dual-energy CT (DECT) an alternative tool which able to identify BME in lower limb.To compare diagnostic performance DECT and osteomyelitis, using clinical, microbiological, data as reference standards.This prospective single-center study enrolled consecutive patients with suspected infections undergoing from December 2020 June 2022. Four blinded...
Our study wanted to describe the kinetics of serological and adaptive immune responses in mpox patients. Methods: Fourteen patients with laboratory-confirmed were tested at different time points after symptom onset. An immunofluorescence assay was performed evaluate seroconversion specific IgA, IgM, IgG. Moreover, characterization immunological profile T- B-cells performed. Results: The antibody revealed faster more effective IgA than IgM. we detected an increase Active memory B cells CD8+...
In a longitudinal study in first-level hospital Luanda, Angola, we found rifampin-resistant and multidrug-resistant tuberculosis (TB) 38 (8%, 95% CI 5.7-10.8) of 474 patients with no previous history TB. Of note, 2 (0.4%, 0.1-1.5) demonstrated pre-extensively drug-resistant
Background Female Genital Schistosomiasis (FGS) is a neglected disease of the genital tract due to inflammatory response presence Schistosoma haematobium eggs in tract. The WHO has prioritized improvement diagnostics for FGS and previous studies have explored PCR-based detection DNA on specimens, with encouraging results. This study aimed determine prevalence among women living an endemic district North-western Tanzania, using PCR samples collected though cervical-vaginal swabs, compare...
Few reliable data are available on Neglected Tropical Diseases (NTDs) and other infections among African refugees asylum seekers in Italy. We aimed to estimate the prevalence of NTDs a large cohort living reception centers Lazio,
Currently approved vaccines are highly effective in protecting against hospitalization and severe COVID-19 infections. How pre-existing immunity responds to new variants with mutated antigens is crucial information for elucidating the functional interplay between antibodies B T cell responses during infection SARS-CoV-2 variants.
With the continuous spread of new SARS-CoV-2 variants concern (VOCs), monitoring diagnostic test performances is mandatory. We evaluated changes in antigen tests’ (ADTs) accuracy along Delta to Omicron VOCs transition, exploring N protein mutations possibly affecting ADT sensitivity and assessing best sampling site for diagnosis infections. In total, 5175 subjects were enrolled from 1 October 2021 15 July 2022. The inclusion criteria combined with a same-day RT-PCR swab test. For analysis,...
Psychological distress imposed by the SARS-CoV-2 outbreak particularly affects patients with pre-existing medical conditions, and progression of their diseases. Patients who fail to keep scheduled appointments experience a negative impact on care. The aim this study is investigate psychosocial factors contributing cancellation during pandemic health conditions. Data were collected in eleven Italian hospitals last week lockdown, one month later. In order assess emotional subject’s degree...
The role of a healthy diet in cancer prevention is well recognized. Recent data indicate that following the same advices can also improve survivors' quality life. Breast (BC) patients are commonly concerned about and nutrition frequently express need to obtain health-related information will change their lifestyle. Hence, be aware dietary changes needs crucial for healthcare professionals guide them toward optimal lifestyle choices. In order investigate eating habits BC population, we...
Background Infection with the filarial nematode Loa loa , endemic in Central and Western Africa, has been associated increased morbidity mortality. A number of reports described presence spleen nodules, originating from degenerating microfilariae, humans animals infected L . The long-term consequences this process on individuals chronically exposed to infection terms function possible link excess mortality are unknown. aim study was evaluate prevalence focal lesions, their evolution over...
ABSTRACT The aim of this study was to identify parameters influencing DNA extraction and PCR amplification efficiencies in an attempt standardize Mucorales qPCR. Fungal Initiative Laboratory Working Group distributed two panels simulated samples 26 laboratories: Panel A (six sera spiked with one negative control serum) B extracts). underwent each laboratory according the local procedure were sent a central for testing using three different qPCR techniques: in-house assay commercial assays...
Tropheryma whipplei (TW), Helicobacter pylori (HP), and intestinal protozoa (IP) are widespread pathogens with similar routes of transmission epidemiological risk factors. Epidemiological data on co-infection between TW, HP, IP scarce. We aim to more deeply investigate the rate for these pathogens, evaluating factors symptoms. Methods: This is a cross-sectional study conducted at IRCCS Sacro Cuore Don Calabria Hospital in Northern Italy, referral center tropical Whipple’s disease (WD)....
We conducted a prospective cohort study at the IRCCS Sacro Cuore Don Calabria Hospital in Negrar di Valpolicella from 2019 to 2021 investigate duration of T. whipplei colonization. In addition, correlation between persistent colonization and continent origin, current treatment regimen, clinical manifestations, parasite coinfection was evaluated. The included subjects who were tested previous (years 2014–2016) found be positive for DNA fecal samples. Thirty-three enrolled 2021. Feces, saliva,...
Rifampicin resistance (RR) is a major challenge in the clinical management of tuberculosis (TB), but data on its prevalence are still sparse many countries. Our study aimed at estimating RR-TB Kajiado County, Kenya. Secondary objectives were to estimate incidence pulmonary TB adults and rate HIV-TB coinfection.We conducted an observational context ATI-TB Project, carried out Kajiado. The project was based active-case-finding campaign implemented with aid village chiefs, traditional healers...
The role of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in early breast cancer treated with preoperative systemic therapy (PST) is not yet established clinical practice. PET parameters have aroused great interest the recent years, as non-invasive dynamic biological markers for predicting response to PST.In this retrospective study, we included 141 patients stage II-III who underwent surgery after PST. Using ROC analysis, set optimal cutoff FDG-PET/CT...
To validate the PAWPER tape and assess its inter-observer reliability in children accessing a Paediatric Emergency Department (PED). As secondary outcome we compared accuracy of with that parents' estimation, Broselow European Life Support (EPLS) formula.