A5053691232- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Parvovirus B19 Infection Studies
- HIV/AIDS Research and Interventions
- Genital Health and Disease
- Respiratory viral infections research
- Molecular Biology Techniques and Applications
- Polyomavirus and related diseases
- COVID-19 and Mental Health
- Olfactory and Sensory Function Studies
- Reproductive tract infections research
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
Centre Hospitalier Universitaire de Besançon
2018-2025
Centre National de la Recherche Scientifique
2024-2025
Université de franche-comté
2011-2024
Johns Hopkins Hospital
2024
Université Bourgogne Franche-Comté
2019-2024
Laboratoire Chrono-Environnement
2024
All India Institute of Medical Sciences Raipur
2023
All India Institute of Medical Sciences Rishikesh
2023
Université de Bourgogne
2022
University of Oxford
2021
Significance A detailed characterization of viral load kinetics and its association with disease evolution is key to understand the virus pathogenesis, identify high-risk patients, design better treatment strategies. We here analyze mortality virological information collected in 655 hospitalized including 284 longitudinal measurements, we build a mathematical model dynamics survival. predict that peak occurs 1 d before symptom onset, on average, decline after slower older patients. Viral...
Coronavirus disease 2019 (COVID-19) may predispose to venous thromboembolism. We determined factors independently associated with computed tomography pulmonary angiography (CTPA)-confirmed embolism (PE) in hospitalised severe COVID-19 patients.Among all (n=349) patients for a university hospital French region high rate of COVID-19, we analysed who underwent CTPA clinical signs (oxygen saturation measured by pulse oximetry ≤93% or breathing ≥30 breaths·min-1) rapid worsening. Multivariable...
New loss of smell or taste was not included as common symptoms COVID-19 until March 2020 when the pandemic started in Western countries. We want to describe prevalence and features anosmia dysgeusia patients.
We aimed to investigate the first Omicron cases detected in France order assess case characteristics and provide supporting information on possible impact of this variant healthcare system. A standardized questionnaire was used collect from confirmed probable cases. Median age 468 investigated 35 years, 376 were symptomatic (89%); 64% vaccinated with two doses 7% had received three doses. Loss smell taste reported by 8.3% 9% cases, respectively. Seven hospitalized, those unvaccinated...
Abstract Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age-distribution, and clinical presentations Europe from 2018-2023. Methods Aggregated data were requested ECDC National Focal Points for Surveillance European Non-Polio Enterovirus Network. Data included detection month, specimen type, age-group, presentation the ten most commonly reported types per year. Findings Twenty-eight...
Objectives There has been increased interest in the possible role of human cytomegalovirus (HCMV) carcinogenesis during last decade. HCMV seroprevalence was enhanced patients with hepatocellular carcinoma (HCC) but a relationship between HCC and infection remained to be assessed. The aim this work investigate pro-tumor influence on primary hepatocytes (PHH) HepG2 cells. Methods Following PHH cells by two different strains HCMV, we measured production IL-6 culture supernatants ELISA protein...
(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID an observational retrospective study in Nord Franche-Comté Hospital France that included adult COVID-19 patients by RT-PCR from 1 March 2020 to 31 May 2020. The aim was describe with post-COVID-19 persistent (PS group) and compare them without (no-PS group). (3) Results. Of 354 patients, 35.9% (n = 127) reported at least one symptom a mean 289.1 ± 24.5...
In 2014, the United States (US) experienced a nationwide outbreak of enterovirus D68 (EV-D68) infection with 1,152 cases reported mainly in hospitalised children severe asthma or bronchiolitis. Following US alert, 11 laboratories French (EV) surveillance network participated an EV-D68 survey. A total 6,229 respiratory samples, collected from 1 July to 31 December were screened for resulting 212 EV-D68-positive samples. These samples corresponded 200 cases. The overall positivity rates among...
ABSTRACT Respiratory viruses are the leading cause of acute infections in humans. However, burden certain respiratory viruses, such as coronaviruses, and relevance viral coinfections remain unclear. In this study, we investigated distribution seasonal occurrences detected by multiplex molecular assay 6,014 samples from 2008 to 2011 a French hospital. We assessed detection frequencies 14 their clinical impact immunosuppressed nonimmunosuppressed patients. Furthermore, explored preferential...
To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), a focus on neuropsychiatric adverse events (NPAEs). Patients 18 HIV reference centres France prospectively included Dat'AIDS cohort. Data collected from all starting INSTI-containing regimen between 1 January 2006 31 December 2016. All discontinuations analysed, patients' characteristics related to due NPAEs sought. INSTIs prescribed 21315...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, usually arising after years of chronic inflammation that could result from viral infections such as hepatitis B virus (HBV) and hepatitic C (HCV) infections. Human cytomegalovirus (HCMV) infects human hepatocytes remains an important cause morbidity in immunocompromised persons where it may manifest symptomatic end-organ disease including hepatitis. The goal present study was to determine a potential correlation between...
We report congenital microencephaly caused by infection with lymphocytic choriomeningitis virus in the fetus of a 29-year-old pregnant women at 23 weeks' gestation. The diagnosis was made ultrasonography and negative results for other agents confirmed positive PCR result an amniotic fluid sample.
In patients with hepatitis C virus (HCV) infection, enhanced activity of indoleamine-2,3-dioxygenase 1 (IDO) has been reported. IDO - a tryptophan-catabolizing enzyme considered as both an innate defence mechanism and important regulator the immune response. The molecular induction in HCV infection its role antiviral response remain unknown. Using primary human hepatocytes, we show that stimulates expression. gene was transient coincided expression types I III interferons (IFNs)...