Timothée Klopfenstein

ORCID: 0000-0003-4334-9889
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About
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Research Areas
  • Long-Term Effects of COVID-19
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Vector-borne infectious diseases
  • Infective Endocarditis Diagnosis and Management
  • Olfactory and Sensory Function Studies
  • Viral Infections and Vectors
  • Yersinia bacterium, plague, ectoparasites research
  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments
  • Dermatological and COVID-19 studies
  • Infectious Diseases and Mycology
  • Peripheral Neuropathies and Disorders
  • Retinal and Optic Conditions
  • Infectious Encephalopathies and Encephalitis
  • Botulinum Toxin and Related Neurological Disorders
  • Cardiac Valve Diseases and Treatments
  • Bacillus and Francisella bacterial research
  • Poxvirus research and outbreaks
  • Respiratory viral infections research
  • Autoimmune and Inflammatory Disorders
  • Advanced Chemical Sensor Technologies
  • Urinary Tract Infections Management
  • Pneumonia and Respiratory Infections
  • Clostridium difficile and Clostridium perfringens research

L'Hôpital Nord Franche-Comté
2020-2024

University of California, Irvine
2023

GlaxoSmithKline (India)
2023

Johnson & Johnson (Israel)
2023

Boehringer Ingelheim (France)
2023

Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant
2022

Méditerranée Infection Foundation
2022

Institut de Recherche pour le Développement
2022

Shaheed Rajaei Cardiovascular Medical and Research Center
2022

Centre Hospitalier Universitaire de Besançon
2018-2020

New loss of smell or taste was not included as common symptoms COVID-19 until March 2020 when the pandemic started in Western countries. We want to describe prevalence and features anosmia dysgeusia patients.

10.1016/j.ijid.2020.08.012 article EN cc-by-nc-nd International Journal of Infectious Diseases 2020-08-07

Abstract We report an outbreak of confirmed Mycoplasma pneumoniae community-acquired pneumonia (CAP) in Nord Franche-Comté Hospital, France, from 14 November 2023 to 31 January 2024. All 13 inpatients (11 adults with a mean age 45.5 years and 2 children) were diagnosed positive serology and/or reverse transcription polymerase chain reaction (RT-PCR) on respiratory specimens. patients immunocompetent required oxygen support duration 6.2 days. Two transferred the intensive care unit (ICU) but...

10.1017/s0950268824000281 article EN cc-by-nc-nd Epidemiology and Infection 2024-01-01

IntroductionNo therapy has proven to be effective yet reduce mortality and/or invasive mechanical ventilation (IMV) requirement in COVID-19. Tocilizumab (TCZ) patients with severe COVID-19 could an treatment.MethodsWe conducted a retrospective case-control study the Nord Franche-Comté Hospital, France. We compared outcome of treated TCZ and without considering combined primary endpoint: IMV requirement.ResultsThirty were 176 TCZ. was used critical condition (oxygen flow at onset 10.5 L/min...

10.1016/j.ijid.2020.08.024 article EN cc-by-nc-nd International Journal of Infectious Diseases 2020-08-13

(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID an observational retrospective study in Nord Franche-Comté Hospital France that included adult COVID-19 patients by RT-PCR from 1 March 2020 to 31 May 2020. The aim was describe with post-COVID-19 persistent (PS group) and compare them without (no-PS group). (3) Results. Of 354 patients, 35.9% (n = 127) reported at least one symptom a mean 289.1 ± 24.5...

10.3390/microorganisms9081719 article EN cc-by Microorganisms 2021-08-12

(1) Background: Leclercia adecarboxylata (L. adecarboxylata) is a gram-negative bacillus of the Enterobacteriaceae family, which uncommonly isolated from clinical specimens. L. considered as an aquatic opportunistic pathogen and most human infections are polymicrobial usually occur in immunocompromised hosts. (2) Methods: In this retrospective study, we included all strains since introduction MALDI-TOF MS Microbiology Department Nord Franche-Comté Hospital, France (from 1 March 2015 to 31...

10.3390/pathogens10111399 article EN cc-by Pathogens 2021-10-28

Earlier studies revealed that 10%-50% of patients reported remaining complaints after treatment for Lyme neuroborreliosis (LNB). The aim our study was to assess symptoms and quality life in with diagnosed treated LNB compare them findings the general population. Adults receiving adequate antibiotics were included between 2015 2021 2 tertiary hospitals. Two controls without borreliosis history each case patient, matched by age geographic area. All participants interviewed answer a...

10.1093/ofid/ofaf042 article EN cc-by-nc-nd Open Forum Infectious Diseases 2025-01-24
François Goehringer Marc Soudant Corentine Alauzet Christine Selton‐Suty Nelly Agrinier and 88 more Jean‐Marc Virion Benjamin Lefèvre Nejla Aissa François Alla Yvon Ruch Yohan N’Guyen Lionel Piroth Kévin Bouiller Pierre‐Yves Royer Vincent Le Moing Bruno Hoen Xavier Duval Nelly Agrinier Corentine Alauzet Nejla Aissa François Alla Xavier Duval François Goehringer Bruno Hoen Benjamin Lefèvre Christine Selton‐Suty Nelly Agrinier Marie‐Line Erpelding Nadine Juge Marc Soudant Jean‐Marc Virion Nejla Aissa Corentine Alauzet Antoine Fraix Marine Frayssinoux François Goehringer Olivier Huttin Benjamin Lefèvre Nathalie Pace Firouzé Bani‐Sadr Maxime Hentzien Anne Limelette Pierre Nazeyrollas Yohan N’Guyen Véronique Vernet-Garnier L. Bohard Kévin Bouiller Catherine Chirouze Pierre‐Edouard Fournier B. Mouhat Noémie Tissot X. Argémi Pierre Boyer Angéline Chabaud François Danion N. Douiri Antoine Grillon Nicolas Lefèbvre Aurélie Martin Yvon Ruch Émilie Talagrand-Reboul Axel Ursenbach Julien Bador Lionel Piroth Pauline Garnier Vincent Gendrin Timothée Klopfenstein Julie Plantin Pierre‐Yves Royer Lynda Toko Jean-Baptiste Vuillemenot Souheil Zayet François Bénézit Loren Dejoies Pierre Tattevin Laurène Deconinck Xavier Duval Nathalie Grall Emila Ilic-Habensus Bernard Iung Catherine Campagnac Sandrine Gerset Isabelle Petitgenet Tuba Ünal Morgane Cangero Benjamin Cuinet Magali Rebucci-Peixoto C. Thiebaut Carole Charles Sandrine Gohier Charlotte Bourgoin Lynda Chalal Sylvie Le Gac

Abstract Background Single-sampling strategy (SSS) for blood cultures (BC) has not been evaluated in infective endocarditis (IE). We assessed the diagnostic performance of SSS vs conventional multi-sampling (MSS) IE diagnosis. Methods Patients suspected were prospectively enrolled 8 tertiary-care centers. Five BC bottle pairs sampled from each patient. Pairs 1, 2 and 3 simultaneously, followed by additional separate (4 5) more than one hour later. 2, emulated 4, 5 MSS. The sensitivity...

10.1093/cid/ciaf163 article EN Clinical Infectious Diseases 2025-04-03

Antimicrobial drugs to treat male urinary tract infection (UTI) with multidrug-resistant Enterobacterales are limited. We studied oral fosfomycin-trometamol (FT) in this situation. The objective was assess the clinical cure rate patients presenting UTIs treated FT.

10.3390/antibiotics11020198 article EN cc-by Antibiotics 2022-02-03

Olfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID-19) remain partially described. ANOSVID is a retrospective study Nord Franche-Comté Hospital (France) that included COVID-19 patients from March 1 2020 to May 31 2020. The aim was compare with OD (OD group) without (no-OD group). A second analysis compared anosmia (high hyposmia or no (low no-OD group presented less cardiovascular other respiratory diseases the (odds ratio [OR] =...

10.1002/jmv.27918 article EN Journal of Medical Virology 2022-06-07

Abstract Background We describe the epidemiological, clinical, and prognostic aspects of 177 tularemia cases diagnosed at National Reference Center for rickettsioses, coxiellosis, bartonelloses between 2008 2017. Methods All patients with a microbiological diagnosis made in laboratory were included. Clinical epidemiological data collected retrospectively from clinicians charge using standardized questionnaire. Diagnostic methods used indirect immunofluorescence serology, real-time polymerase...

10.1093/ofid/ofaa440 article EN cc-by-nc-nd Open Forum Infectious Diseases 2020-09-19

Many studies have investigated post-COVID symptoms, but the predictors of symptom persistence remain unknown. The objective was to describe natural course disease at 6 months and identify possible factors favoring resurgence or these symptoms. COVEVOL is a retrospective observational descriptive study 74 patients. All patients with positive SARS-CoV-2 PCR from March 2020 were included. We compared group (PS group) another without (no-PS group). Fifty-three out seventy-four (71.62%) described...

10.3390/v13112151 article EN cc-by Viruses 2021-10-25

Abstract A 26-year-old patient in France who worked as a butcher sought care initially for erythema multiforme. Clinical examination revealed nodule with crusty center, which upon investigation appeared to be an orf nodule. Diagnosis was confirmed by PCR. The not isolated and had favorable outcome after basic wound care.

10.3201/eid2904.230058 article EN cc-by Emerging infectious diseases 2023-03-29
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