A5044449649- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Antifungal resistance and susceptibility
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Childhood Cancer Survivors' Quality of Life
- Infectious Diseases and Mycology
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Eosinophilic Disorders and Syndromes
- CAR-T cell therapy research
- Polyomavirus and related diseases
- COVID-19 and healthcare impacts
Université Paris Cité
2016-2025
Hôpital Saint-Louis
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2014-2024
Délégation Paris 7
2014-2024
Sorbonne Paris Cité
2012-2017
Palmetto Hematology Oncology
2015
Centre Hospitalier Universitaire Henri-Mondor
2013
Development Fund
2013
This intercontinental study aimed to gram-negative rod (GNR) resistance in hematopoietic stem cell transplantation (HSCT).GNR bacteremias occurring during 6 months post-HSCT (February 2014-May 2015) were prospectively collected, and analyzed for rates risk factors fluoroquinolones, noncarbapenem anti-Pseudomonas β-lactams (noncarbapenems), carbapenems, multidrug resistance.Sixty-five HSCT centers from 25 countries Europe, Australia, Asia reported data on 655 GNR episodes 704 pathogens 591...
This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) Spanish Group of Hematopoietic Stem Cell (GETH). The median age was 54.1 years (1.0-80.3) allogeneic, 60.6 (7.7-81.6) HCT patients. time from 15.8 months (0.2-292.7) in 24.6 (-0.9 350.3) recipients. 83.5% developed lower respiratory tract disease 22.5% were admitted an ICU....
Thrombotic microangiopathy (TMA) occurring after allogeneic hematopoietic stem cell transplantation (HSCT) has a devastating prognosis. Response rates to current therapies (mainly plasma exchange) are unsatisfactory. HSCT shares similarities with atypical hemolytic uremic syndrome (aHUS) in the underlying pathomechanisms. Eculizumab been associated impressive results aHUS.We retrospectively analyzed 12 patients who received France between 2010 and 2013 for severe post-HSCT TMA.All had TMA...
Clostridium difficile (C. difficile) infection was observed in 13% of recipients after hematopoietic stem cell transplantation (HSCT), mainly the first month posttransplantation. Risk factors were cord blood as source cells, acute graft-versus-host disease (GVHD), and total body irradiation (TBI). No association found with an increased risk mortality. The purpose this study to evaluate incidence, factors, outcome C. (CDI) HSCT. We conducted a single-center, retrospective, cohort on all...
There is no consensus on the optimal treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation. In our center, policy has changed over time with mycophenolate mofetil (MMF) being used from 1999 to 2003, and etanercept or inolimomab 2004. An observational study compared survival infection rates in all consecutive patients receiving 1 these 3 treatments. Ninety-three were included. The main end point was overall (OS)....
For older patients with acute myeloid leukemia (AML), allogeneic hematopoietic cell transplantation (HCT) provides the best chance of long-term survival. A formal comparison between matched sibling (SIB), unrelated donor (URD), or umbilical cord blood (UCB) has not yet been reported in this setting. We compared reduced-intensity conditioning HCT 197 consecutive 50 years and AML complete remission from SIB (n = 82), URD 35), UCB 80) transplantation. The 3-year cumulative incidences...
Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might associated with long-lasting immune deficiency. Sixty-six patients who underwent a first from either UCB (n = 30) 9/10 MMUD 36) and survived beyond 3 months were evaluated. Immune reconstitution was prospectively assessed at sequential time points after transplantation. NK, B, CD4(+), CD8(+) T cells their naïve memory subsets, well regulatory...
Performing a pretransplantation splenectomy in patients with myelofibrosis (MF) is matter of debate, as while the procedure improves hematological recovery, it may lead to severe morbidities. We retrospectively analyzed data from 85 consecutive who underwent transplantation our center for MF, including 39 before their transplantation. A majority them had primary MF (78%), were considered high-risk (84% dynamic international prognostic scoring system intermediate-2 or higher), and received...
Introduction COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Methods This study reports on 986 patients reported to the EBMT registry during first 29 months of pandemic. Results The median age was 50.3 years (min – max; 1.0 80.7). time from most recent HCT diagnosis 20 0.0 383.9). 19.3 (0.0 - 287.6) 2020, 21.2 (0.1 324.5) 2021, 19.7 383.9) 2022 (p = NS). 145/986 (14.7%) died; 124 (12.6%) due 21 other...
Central nervous system (CNS) involvement of graft versus host disease (GvHD) is a rare cause CNS disorders after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Chronic GvHD symptoms are heterogeneous and include cerebrovascular manifestations, demyelinating immune-mediated encephalitis. CNS-Acute not formally defined in literature.We report 7 cases CNS-GvHD among which two had histological-proven disease. We reviewed 32 additional published literature since 1990. In this...
Objective Febrile neutropenia (FN) is a serious clinical event, associated with significant morbidity and mortality. Imaging has central role in the identification of fever cause. The study objectives were to assess abnormalities potential infectious origin on paranasal sinus, chest abdomen/pelvis CT scans performed during an episode FN, patients or without specific signs, evaluate their impact frequency changes treatment. Materials methods This retrospective included 306 FN from single...
Abstract Background While invasive fusariosis and lomentosporiosis are known to be associated with fungemia, overall data on mold-related fungemia limited, hampering early management. This study aimed describe the epidemiology of mold-positive blood cultures. Methods Epidemiological clinical cultures from 2012 2022 were obtained RESSIF database. Pseudofungemia was excluded using modified Duthie Denning criteria. Univariable multivariable Firth logistical regression used factors 90-day...