A5008298910- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Drug-Induced Hepatotoxicity and Protection
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Spectroscopy Techniques in Biomedical and Chemical Research
- HIV-related health complications and treatments
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Blood groups and transfusion
- Glycosylation and Glycoproteins Research
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2014-2025
Hôpital Cochin
2015-2024
Université Paris Cité
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Sorbonne Paris Cité
2013-2023
Hôpital Lariboisière
2023
Demos
2023
Inserm
2011-2022
Université Claude Bernard Lyon 1
2022
Délégation Paris 5
2011-2021
Abstract To optimize the management of patients with chronic hepatitis C virus (HCV) infection, noninvasive tests to determine degree hepatic fibrosis have been developed. The aims this study were (1) validate a simple, inexpensive, test called FIB-4, which combines standard biochemical values (platelets, ALT, AST) and age, in series 847 liver biopsies performed HCV-monoinfected patients; (2) compare results 780 FIB-4 FibroTests same day 592 HCV-infected patients. index enabled correct...
There is no established therapy for hepatitis E virus (HEV) infection. The aim of this retrospective, multicenter case series was to assess the effects ribavirin as monotherapy solid-organ transplant recipients with prolonged HEV viremia.
<h3>Background</h3> Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. <h3>Methods</h3> Using liver histology as a gold standard, we developed novel index using routine laboratory to predict significant patients with chronic HBV infection The Gambia, West We prospectively assessed the diagnostic accuracy of index, Fibroscan, aspartate transaminase-to-platelet ratio (APRI), Fib-4 Gambian CHB (training set) also French...
Background: The effect of regression cirrhosis in chronic hepatitis C is unknown. Objective: To evaluate the relation between and clinical outcome patients with after antiviral therapy. Design: A cohort treated 1988 2001. Setting: Hepatology unit a tertiary care center France. Patients: 96 biopsy-proven (METAVIR score F4) who were an interferon-based regimen had at least 1 posttreatment liver biopsy. Patients followed until November 2006. Measurements: Occurrence combined end point...
Background Apoptosis has been shown to contribute myocardial reperfusion injury. It suggested that, in reducing the apoptotic component within ischemic area at risk, Bcl-2 overexpression could lead a ventricular function improvement. Methods Transgenic mice overexpressing anti-apoptotic human cDNA heart were subjected 1-h left coronary artery occlusion followed by 24-h reperfusion. At end of experiment, was assessed two-dimensional echocardiography. After sacrifice, risk (AR) and infarct...
Chronic infection with hepatitis C virus (HCV) is a major public health problem, nearly 170 million infected individuals worldwide. Current treatment for chronic combination of pegylated IFN-α2 and ribavirin (RBV); however, this effective in fewer than 50% patients HCV genotype 1 or 4. Recent studies identified the chemokine CXCL10 (also known as IP-10) an important negative prognostic biomarker. Given that mediates chemoattraction activated lymphocytes, it counterintuitive correlates...
Background: There is currently no accepted treatment of chronic hepatitis E virus (HEV) infection. Objective: To report 2 patients in whom ribavirin therapy seemed to alter the natural history HEV Design: Case reports. Setting: Hepatology unit a tertiary care center France. Patients: A kidney and pancreas transplant recipient patient with idiopathic CD4+ T lymphocytopenia, both biopsy-proven Intervention: Patients received oral ribavirin, 12 mg/kg body weight daily for weeks. Measurements:...
In Brief Background/Objective: Oxaliplatin-based chemotherapy induces sinusoidal obstruction syndrome (SOS) lesions in the nontumorous liver parenchyma, which may increase risk of resection for colorectal metastases. The objective this study was to evaluate accuracy aspartate aminotransferase platelet ratio index (APRI) and FIB-4 scoring systems predict chemotherapy-associated injury correlate severity with postoperative outcome. Methods: Between 1998 2007, 78 patients were operated...
Abstract Introduction Esophageal Doppler provides a continuous and non-invasive estimate of descending aortic blood flow (ABF) corrected left ventricular ejection time (LVETc). Considering passive leg raising (PLR) as reversible volume expansion (VE), we compared the relative abilities PLR-induced ABF variations, LVETc respiratory pulsed pressure variations (ΔPP) to predict fluid responsiveness. Methods We studied 22 critically ill patients in acute circulatory failure supine position,...
Abstract Background Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV) infection. This retrospective European multicenter study aimed to assess the sustained virological response (SVR) in a large cohort of solid organ transplant (SOT) recipients with HEV infection treated ribavirin monotherapy (N = 255), identify predictive factors SVR, and evaluate impact RNA mutations on response. Methods Data from 255 SOT 30 centers were analyzed. was given at median dose 600...
Objective: To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension. Methods: The study was undertaken at a centre Paris involved 97 HIV-infected presenting abnormal function tests and/or symptomatic hypertension unknown origin. Serology, pathology, were performed. Results: A clear nodular architecture corresponding to regenerative hyperplasia observed seven suggested one, based on presence sinusoidal...
The Fib-4 index is a simple and inexpensive biomarker to delineate liver fibrosis in chronic hepatitis C.To assess the accuracy of FIB-4 B.We compared with 138 synchronous biopsies 372 FibroTest performed either France or an endemic area (Mayotte, overseas collectivity France).The allowed correct identification patients nil-to-moderate under receiving operating characteristic curve 0.81 (P < 0.001), increasing as function length biopsy (up 0.94 for >or=20 mm). A cut-off value <or=1.45...
Background: Measurement of liver stiffness ( LS ) using real‐time elastography appears as a promising tool to evaluate the severity chronic diseases. Previous studies in patients with alcoholic disease have suggested that fibrosis was only histological parameter influence . To challenge this hypothesis, we prospectively tested short‐term impact alcohol withdrawal on value. Methods: Patients hospitalized for our L iver and A ddiction U nit between 2007 2010 had an determination at entry D 0)...