A5020745510- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Plant Pathogens and Fungal Diseases
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Cystic Fibrosis Research Advances
- Infectious Diseases and Mycology
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Plant Pathogenic Bacteria Studies
- Infection Control and Ventilation
- T-cell and B-cell Immunology
- Medical Device Sterilization and Disinfection
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
University of Duisburg-Essen
2016-2025
Nuremberg Hospital
2018-2025
Paracelsus Medical University
2018-2025
Essen University Hospital
2014-2024
Paracelsus Medizinische Privatuniversität
2018-2024
Taipei Medical University Hospital
2021
Ondine Biopharma (United States)
2021
Ostbayerische Technische Hochschule Amberg-Weiden
2021
MD Precision (Canada)
2021
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2017-2019
The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity WHO a comparative analysis. Zika virus (ZIKV), Ebola (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East (MERS-CoV) as viral pathogens other enveloped viruses could...
Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence CAPA patients with intensive care units (ICU) and investigate risk factors for well outcome.The European Confederation Medical Mycology (ECMM) conducted including 20 centres from nine countries assess epidemiology, outcome CAPA. was defined according 2020 ECMM/ISHAM...
<h3>Objective</h3> Hepatitis C virus (HCV) infection causes severe liver disease and affects more than 160 million individuals worldwide. People undergoing organ transplantation face universal re-infection of the graft. Therefore, affordable antiviral strategies targeting early stages are urgently needed to prevent recurrence HCV infection. The aim study was determine potency turmeric curcumin as an entry inhibitor. <h3>Design</h3> activity its derivatives evaluated using pseudo-particles...
Abstract Objectives Aspergillus fumigatus is the most common agent of invasive aspergillosis (IA). In recent years, resistance to triazoles, mainstay IA therapy, has emerged in different countries worldwide. caused by azole-resistant A. (ARAF) shows an exceedingly high mortality. this study, due ARAF isolates HSCT recipients Germany was investigated. Methods The epidemiology azole analysed two German haematology departments. Between 2012 and 2013, 762 patients received Essen (n = 388)...
Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure clonality at level. We show that S. complex is divided into 23 monophyletic lineages, most which harbour strains all degrees human virulence. Lineage Sm6 comprises highest rate human-associated...
Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients cystic fibrosis (CF). We observed that β1-integrins accumulate on luminal membrane upper-airway epithelial cells from mice humans CF. β1-integrin accumulation due to increased ceramide formation platforms trap pole bronchial cells. downregulate acid ceramidase expression, resulting further consequent reduction surface sphingosine, a lipid...
Hepatitis E virus (HEV) is the causative agent of hepatitis in humans and leading cause for acute viral worldwide. The classified as a member genus Orthohepevirus A within Hepeviridae family. Due to absence robust cell culture model HEV infection, analysis life cycle, development effective antivirals vaccine severely limited. In this study, we established protocol based on genotype 3 p6 (Kernow C-1) human hepatoma lines HepG2 HepG2/C3A with different media conditions produce intracellular...
Introduction/Objectives An increase in antifungal resistant Candida strains has been reported recent years. The aim of this study was to detect mutations resistance genes azole-resistant, echinocandin-resistant or multi-resistant using next generation sequencing technology, which allows the analysis multiple mechanisms a high throughput setting. Methods Forty clinical isolates (16 C. albicans and 24 glabrata strains) with MICs for azoles echinocandins above EUCAST breakpoint were examined....
The broad-spectrum triazole isavuconazole is used for the treatment of invasive aspergillosis and mucormycosis. Data regarding human plasma concentrations in clinical routine drug are rare.Plasma were determined critically ill ICU patients while considering different patients' characteristics.Retrospective analysis obtained as part therapeutic monitoring (TDM) with or other fungal infections treated isavuconazole. Plasma levels 0-4 h after last dosing defined peak (Cmax ), those 20-28 trough...
Quantitative real-time PCR (qPCR) is increasingly used to detect Pneumocystis jirovecii for the diagnosis of pneumonia (PCP), but there are differences in nucleic acids targeted, DNA only versus whole acid (WNA), and also target genes amplification. Through Fungal Initiative, a working group International Society Human Animal Mycology, multicenter monocenter evaluation PCP qPCR assays was performed. For study, 16 reference laboratories from eight different countries, performing 20 analyzed...
Invasive fungal infections caused by Lomentospora prolificans are associated with very high mortality rates and can be challenging to treat given pan-drug resistance available antifungal agents. The objective of this study was describe the clinical presentation outcomes in a cohort patients invasive L infections.We performed retrospective review medical records infection FungiScope® registry rare infections. Patients diagnosed between 01 January 2008 09 September 2019 were included for...
Most COVID-19-associated mucormycosis (CAM) cases are reported from India and neighbouring countries. Anecdotally Europe have been presented.To estimate the disease burden describe clinical presentation of CAM in Germany.We identified through German mycology networks scientific societies, collected anonymised information via FungiScope®.We 13 six tertiary referral hospitals diagnosed between March 2020 June 2021. Twelve patients had severe or critical COVID-19, eleven were mechanically...
The spread of nonzoonotic monkeypox virus (MPXV) infections necessitates the reevaluation hygiene measures. To date, only limited data are available on MPXV surface stability. Here, we evaluate stability infectious stainless steel stored at different temperatures, while using interfering substances to mimic environmental contamination. persistence increased with decreasing temperature. Additionally, were able show that could efficiently be inactivated by alcohol- and aldehyde-based...