A5041454251- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Enterobacteriaceae and Cronobacter Research
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogens and Fungal Diseases
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Neutropenia and Cancer Infections
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Fungal Biology and Applications
- Gut microbiota and health
- Immune Response and Inflammation
- Escherichia coli research studies
- Probiotics and Fermented Foods
- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
Carl von Ossietzky Universität Oldenburg
2019-2025
Klinikum Oldenburg
2021-2025
University Hospital Cologne
2016-2025
University of Cologne
2015-2024
German Center for Infection Research
2015-2024
KU Leuven
2023
Institute of Medical Microbiology and Hygiene
2019-2022
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2016-2020
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2019
University of Würzburg
2019
Abstract Objectives Aspergillus fumigatus is the most common agent of invasive aspergillosis (IA). In recent years, resistance to triazoles, mainstay IA therapy, has emerged in different countries worldwide. caused by azole-resistant A. (ARAF) shows an exceedingly high mortality. this study, due ARAF isolates HSCT recipients Germany was investigated. Methods The epidemiology azole analysed two German haematology departments. Between 2012 and 2013, 762 patients received Essen (n = 388)...
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem consumption. Alternatives carbapenems need be investigated. We investigated whether β-lactam/β-lactamase inhibitor (BLBLI) combinations are as effective in the treatment bloodstream infections (BSI) due ESBL-E. A multinational, retrospective cohort study was performed. Patients with monomicrobial BSI ESBL-E were studied; specific criteria applied for inclusion patients...
Resistance to 3rd-generation cephalosporins in Escherichia coli is mostly mediated by extended-spectrum beta-lactamases (ESBLs) or AmpC beta-lactamases. Besides overexpression of the species-specific chromosomal ampC gene, acquisition plasmid-encoded genes, e.g. blaCMY-2, has been described worldwide E. from humans and animals. To investigate a possible transmission blaCMY-2 along food production chain, we conducted next-generation sequencing (NGS)-based analysis 164 CMY-2-producing isolates...
Up to 25% of patients with profound neutropenia lasting for >10 days develop lung infiltrates, which frequently do not respond broad-spectrum antibacterial therapy. While a causative pathogen remains undetected in the majority cases, Aspergillus spp., Pneumocystis jirovecii, multi-resistant Gram-negative pathogens, mycobacteria or respiratory viruses may be involved. In at-risk who have received trimethoprim–sulfamethoxazole (TMP/SMX) prophylaxis, filamentous fungal pathogens appear...
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised occasionally healthy hosts. is intrinsically resistant to most, L. all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up 90% underline need for comprehensive diagnostic workup even more new, effective improve patient outcome. For a analysis, we identified cases severe from literature diagnosed 2000 or later...
The selection pressure exercised by antibiotic drugs is an important consideration for the wise stewardship of antimicrobial treatment programs. Treatment decisions are currently based on crude assumptions, and there urgent need to develop a more quantitative knowledge base that can enable predictions impact individual antibiotics human gut microbiome resistome.Using shotgun metagenomics, we quantified changes in two cohorts hematological patients receiving prophylactic antibiotics; one...
This study characterized a new variant of the New Delhi metallo-β-lactamase (NDM). A multidrug-resistant Escherichia coli isolate was recovered from wounds, throat and rectum Yemeni patient who presented at Frankfurt University Hospital in Germany. The presence β-lactamase genes analysed by PCR sequencing. further susceptibility testing, conjugation transformation assays plasmid analysis. E. resistant to all β-lactams including carbapenems. By analysis, blaCMY-2, blaCTX-M-15, blaTEM-1 blaNDM...
ObjectivesThe aim of this study was to evaluate the performance five different carbapenemase tests and develop an algorithm which will permit detection most common rare carbapenemases in routine microbiology laboratories.MethodsThe immunochromatographic CARBA-5 (NG), RESIST-4 O.K.N.V. (Coris), colorimetric β-CARBA (BioRad), a newly developed carbapenem-inactivation method (CIM) supplemented with zinc (zCIM), Xpert Carba-R (Cepheid) were challenged collection 189 molecularly characterized...
Bloodstream infections (BSIs) caused by enterobacteria remain a leading cause of mortality in patients with chemotherapy-induced neutropenia. The rate and type colonization infection ESBL-producing Enterobacteriaceae (ESBL-E) their mode transmission German cancer centres is largely unknown. We performed prospective, observational study at five university-based haematology departments. Participating sites screened for intestinal ESBL-E within 72 h admission, every 10 ± 2 days thereafter...
The objectives of this study were to prospectively assess the rectal carriage rate third-generation cephalosporin-resistant Enterobacteriaceae (3GCREB) in non-ICU patients on hospital admission and investigate resistance mechanisms risk factors for carriage. Adult screened 3GCREB at six German tertiary care hospitals 2014 using swabs or stool samples. isolates characterized by phenotypic molecular methods. Each patient answered a questionnaire about potential colonization with MDR organisms...
Summary Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients scarce evidence is available for treatment decisions. Among 505 cases of IFD from the FungiScope ™ registry, we identified 23 infections caused by these reported 10 countries over a 12‐year period. All were adults previous chemotherapy with associated neutropenia was most common co‐morbidity. Fungaemia confirmed 14 (61%) deep organ involvement included lungs, liver,...
Species within the Enterobacter cloacae complex (ECC) include globally important nosocomial pathogens. A three-year study of ECC in Germany identified xiangfangensis as most common species (65.5%) detected, a result replicated by examining global pool 3246 isolates. Antibiotic resistance profiling revealed widespread and heteroresistance to antibiotic colistin detected mobile (mcr)-9 gene 19.2% all We show that properties depend on chromosomal arnBCADTEF cassette whose products catalyze...
The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia and Morganella morganii) has not yet been incorporated into systematic surveillance programs. We conducted a multicentre retrospective observational study analysing all strains isolated from blood cultures in 27 European hospitals over 3-year period (2020-2022). Diagnostic approach, epidemiology, antimicrobial susceptibility were...
Abstract Infections due to multidrug-resistant organisms (MDROs) are a health threat increasing patient morbidity and mortality the burden on healthcare systems. Robust infection prevention control (IPC) measures needed minimize their emergence in hospitals. Therefore, various international national IPC guidelines exist, yet lack of harmonized complicates management patients seeking across European borders. This study explores similarities differences for vancomycin-resistant enterococci...
keratitis is a destructive eye infection that difficult to treat and results in poor outcome. In tropical subtropical areas, the relatively common associated with trauma or chronic diseases. However, recent years, an increased incidence has been reported temperate climate regions. At German National Reference Center, we have observed steady increase case numbers since 2014. Here, present first series of infections
Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens members the section Fumigati followed by Terrei. frequency terreus and related (cryptic) clinical specimens, as well percentage azole-resistant strains remains to be studied. Methods: A global set (n = 498) A. phenotypically isolates was molecularly identified (beta-tubulin), tested for antifungal...
ObjectivesAspergillus spp. are the most frequently isolated filamentous fungi in sputum of patients with cystic fibrosis (CF). Resistance to azoles, mainstay current antifungal therapy, has been increasingly observed worldwide, but few data available on resistance Aspergillus German CF patients. This study investigated epidemiology and molecular origin azole a large centre.
ABSTRACT The mechanism of stepwise acquired multidrug resistance in Acinetobacter baumannii isolates from a hospitalized patient was investigated. Thirteen consecutive multidrug-resistant were recovered the same over 2-month period. Vitek 2 system identified as meropenem-sensitive lwoffii ; however, molecular identification showed that A. . Etest revealed meropenem resistant. presence oxacillinase (OXA)-type enzymes investigated by sequencing. clonal relatedness assessed pulsed-field gel...
Bloodstream infections (BSIs) due to ESBL-producing Enterobacteriaceae (ESBL-E) are frequent yet outcome prediction rules for clinical use have not been developed. The objective was define and validate a predictive risk score 30 day mortality.A multinational retrospective cohort study including consecutive episodes of BSI ESBL-E performed; cases were randomly assigned derivation (DC) or validation (VC). main variable all-cause mortality. A developed using logistic regression coefficients the...