A5043540405- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Infection Control and Ventilation
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Dental Research and COVID-19
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- COVID-19 epidemiological studies
- HIV Research and Treatment
- Animal Disease Management and Epidemiology
- interferon and immune responses
- Wastewater Treatment and Reuse
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Infection Control in Healthcare
- Constructed Wetlands for Wastewater Treatment
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
Ruhr University Bochum
2018-2025
Friedrich Schiller University Jena
2022-2025
Institute of Medical Microbiology and Hygiene
2024
Center for Experimental and Clinical Infection Research
2014-2022
Helmholtz Centre for Infection Research
2016-2020
University of Bern
2020
Essen University Hospital
2020
Paracelsus Medizinische Privatuniversität
2020
Charité - Universitätsmedizin Berlin
2020
Universitätsmedizin Greifswald
2020
Infection control instructions call for use of alcohol-based hand rub solutions to inactivate severe acute respiratory syndrome coronavirus 2. We determined the virucidal activity World Health Organization-recommended formulations, at full strength and multiple dilutions, active ingredients. All disinfectants demonstrated efficient virus inactivation.
The World Health Organization (WHO) published 2 alcohol-based formulations to be used in healthcare settings and for outbreak-associated infections, but inactivation efficacies of these products have not been determined against (re-)emerging viruses. In this study, we evaluated the virucidal activity WHO a comparative analysis. Zika virus (ZIKV), Ebola (EBOV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East (MERS-CoV) as viral pathogens other enveloped viruses could...
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic creates a significant threat to global health. Recent studies suggested the significance of throat and salivary glands as major sites virus replication transmission during early disease 2019, thus advocating application oral antiseptics. However, antiviral efficacy rinsing solutions against SARS-CoV-2 has not been examined. Here, we evaluated virucidal activity different available rinses under conditions...
The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions people worldwide. Despite one year intensive research, the current treatment options for infected are still limited. Clearly, novel antiviral compounds patients urgently needed. Complementary medicine is used along with standard medical and accessible to vast majority Natural products activity may contribute improve overall condition individuals. In present study, we investigated glycyrrhizin, primary active...
<h3>Objective</h3> Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and failure. Ribavirin (RBV) is currently the only treatment option for many patients, but failure occur which has been associated with appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed detailed analysis viral intrahost evolution during hepatitis infections. <h3>Design</h3> Illumina deep sequencing was detection variation...
Summary Hepatitis E virus ( HEV ) is the causative agent of hepatitis in humans and a member genus Orthohepevirus family Hepeviridae . Infection usually leads to acute that can become fulminant, particularly among pregnant women patients with preexisting liver disease, or may evolve chronic state, especially immunosuppressed individuals. has been shown produce range extra‐hepatic manifestations including aplastic anaemia, thyroiditis, glomerulonephritis as well neurological disorders such...
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2, a new member of the genus Betacoronavirus, is pandemic virus, which has caused numerous fatalities, particularly in elderly and persons with underlying morbidities. At present, there are no approved vaccines nor antiviral therapies available. The detection quantification SARS-CoV-2-neutralizing antibodies plays crucial role assessment immune status convalescent COVID-19 patients, evaluation recombinant therapeutic antibodies,...
Hepatitis E virus (HEV) is the causative agent of hepatitis in humans and leading cause for acute viral worldwide. The classified as a member genus Orthohepevirus A within Hepeviridae family. Due to absence robust cell culture model HEV infection, analysis life cycle, development effective antivirals vaccine severely limited. In this study, we established protocol based on genotype 3 p6 (Kernow C-1) human hepatoma lines HepG2 HepG2/C3A with different media conditions produce intracellular...
Significance Type I interferons (IFN-I) exhibit various biological effects during viral infections, and they have been successfully used for clinical treatment of diseases. Humans express 12 IFNα subtypes, which strongly differ in their antiviral responses against different viruses. Here we analyzed the activity all human subtypes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to identify underlying immune signatures explore therapeutic potential. Our data provide a systemic...
Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some infections. To investigate the potential VAERD induction in coronavirus 2019 (COVID-19), we evaluate two vaccine leads utilizing hamster infection model: T helper type 1 (TH1)-biased measles vaccine-derived candidate and TH2-biased alum-adjuvanted, non-stabilized spike protein. The virus (MeV)-derived protects animals, but protein lead induces VAERD, which can be alleviated by dexamethasone treatment....
Hepatitis C virus (HCV) is a positive-strand RNA that primarily infects human hepatocytes. Infections with HCV constitute global health problem, 180 million people currently chronically infected. Recent studies have reported cholesterol 25-hydroxylase (CH25H) expressed as an interferon-stimulated gene and mediates antiviral activities against different enveloped viruses through the production of 25-hydroxycholesterol (25HC). However, intrinsic regulation CH25H (hCH25H) expression within...
ABSTRACT Hepatitis E virus (HEV) is the causative agent of hepatitis in humans and a member genus Orthohepevirus family Hepeviridae . HEV infections are common cause acute but can also take chronic courses. Ribavirin treatment choice for most patients, type I interferon (IFN) has been evaluated few infected transplant patients vivo In this study, antiviral effects different exogenously administered interferons were investigated by using state-of-the-art subgenomic replicon full-length genome...
Hepatitis E virus (HEV) is the causative agent of hepatitis in humans and a member genus Orthohepevirus family Hepeviridae. HEV infections are common cause acute but can also take chronic courses. Ribavirin treatment choice for most patients type I interferon (IFN) has been evaluated few infected transplantation vivo. However, no effective specific treatments against currently available. In this study, we natural compound silvestrol, isolated from plant Aglaia foveolata, known its inhibition...
Hand disinfectants are important for the prevention of virus transmission in health care system and environment. The development broad antiviral spectrum hand with activity against enveloped non-enveloped viruses is limited due to a small number permissible active ingredients able inactivate viruses. A new disinfectant was developed based upon 69.39 % w/w ethanol 3.69 2-propanol. Different amounts citric acid urea were added order create virucidal claim poliovirus (PV), adenovirus type 5...
Hepatitis E virus (HEV) genotype 3 infections are frequent in Europe and North America, with acute chronic courses described the literature. HEV RNA detection by real-time polymerase chain reaction (PCR) is gold standard for diagnosis. Recently, an anti-HEV antigen (Ag)-specific enzyme-linked immunosorbent assay (ELISA) directed against capsid became commercially available. The effectiveness of Ag-specific ELISA at detecting remains undefined.The performance Ag-ELISA was compared that PCR,...