A5046687928- Phytoestrogen effects and research
- Paraoxonase enzyme and polymorphisms
- SARS-CoV-2 and COVID-19 Research
- Coenzyme Q10 studies and effects
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Natural Antidiabetic Agents Studies
- Soft Robotics and Applications
- Immune Cell Function and Interaction
- Retinoids in leukemia and cellular processes
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Augmented Reality Applications
- RNA Interference and Gene Delivery
- Insect Pest Control Strategies
- Gastric Cancer Management and Outcomes
- Neuroendocrine regulation and behavior
- Gastrointestinal Bleeding Diagnosis and Treatment
- interferon and immune responses
- Parasites and Host Interactions
- Cancer Research and Treatments
- Research on Leishmaniasis Studies
- Virus-based gene therapy research
- Lanthanide and Transition Metal Complexes
- Receptor Mechanisms and Signaling
Jining Medical University
2025
University of Saskatchewan
2013-2022
Significance Type I interferons (IFN-I) exhibit various biological effects during viral infections, and they have been successfully used for clinical treatment of diseases. Humans express 12 IFNα subtypes, which strongly differ in their antiviral responses against different viruses. Here we analyzed the activity all human subtypes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to identify underlying immune signatures explore therapeutic potential. Our data provide a systemic...
Parenteral amphotericin B has been considered as first-line therapy in the treatment of systemic fungal and parasitic infections, however its use associated with a number limitations including affordability, accessibility, an array toxicities. Until very recently, it challenging to develop bioavailable formulation due physical chemical properties, limited water lipid solubility, poor absorption. This perspective reviews several novel oral Amphotericin formulations under development that are...
Systemic cytotoxic chemotherapy remains the mainstay of metastatic breast cancer; however, prognosis and overall survival is unfavorable due to inadequate treatment response and/or unacceptable toxicity. Natural compounds their active metabolites receive increasing attention as possible adjuvant therapy with cancer chemotherapeutics improve response, rates, quality life patients. This study investigated combination flaxseed lignans (Secoisolariciresinol Enterolactone) classic...
Evidence from the literature suggests that dietary flaxseed lignans have ability to modulate inflammation, which is recognized as underlying basis of multiple chronic human diseases in older adults. Our objective was determine effects oral lignan supplementation on biochemical and functional indicators inflammation well safety tolerability healthy We designed a randomized, double-blind, placebo-controlled clinical trial adults (60–80 years) assess lignan–enriched complex (∼38%...
Background: Increased oxidative stress and inflammation are associated with aging, contribute to an increased risk of chronic disease in older adults. Flaxseed lignans demonstrate antioxidant anti-inflammatory activity, but their ability reduce markers adult populations has received limited investigation. Objective: This is a intervention trial community-dwelling healthy adults examine the effects flaxseed lignan (secoisolariciresinol diglucoside; SDG) enriched supplement (BeneFlax) compared...
Interferon-alpha (IFN-α) has been associated with excessive immune activation and dysfunction during HIV-1 infection. However, evidence suggests specific IFN-α subtypes may be beneficial rather than detrimental. This study compared the effects of treatment two different on indicators T-cell infection.Humanized mice were infected for 5 weeks then treated an additional 3 weeks. Splenic T cells assessed both immediately posttreatment again 6 after cessation.HIV-1 triple-knockout bone...
Small animal models that accurately model pathogenesis of SARS-CoV-2 variants are required for ongoing research efforts. We modified our human immune system mouse to support replication by implantation lung tissue into the mice create TKO-BLT-Lung (L) and compared infection with two different in a humanized model. Infection TKO-BLT-L recapitulated higher infectivity B.1.1.7 variant more animals becoming infected sustained viral loads challenged an early B lineage (614D) virus. Viral lesions...
The purpose of this study was to evaluate the efficacy and toxicity a novel lanthanum compound, La(XT), in an ovariectomized (OVX) rat model osteoporosis. Twenty-four female Sprague Dawley rats were divided into 3 groups receiving research diet with/without treatment compounds (alendronate: mg/kg; La(XT) 100 mg/kg) for three months. At time sacrifice, kidney, liver, brain, lung spleen collected histological examination. trabecular bone structure tibiae evaluated using micro-CT three-point...
Purpose: CPX-351 is a liposomal formulation of cytarabine and daunorubicin encapsulated at 5:1 molar ratio, for the treatment acute myeloid leukemia. The Scavenger Receptor class B type I (SR-BI) plays an important role in mediating uptake high-density lipoproteins. purpose this study to assess cell surface lipoprotein receptor SR-BI liposomes (Jazz Pharmaceuticals) into K562 leukemia cells.Methods: cells were pre-treated with 10 nM siRNA 48 h then treated varying amount 24, 72 h. Cells...
Increasing evidence from preclinical and clinical studies demonstrate that dietary flaxseed lignans may have a role in prevention treatment of prostate cancer. The enterolactone (ENL) secoisolariciresinol (SECO) contribute to the anticancer effect. Our vitro cytotoxicity found ENL SECO reduced IC 50 values chemotherapeutic agents specific membrane antigen (PSMA) positive negative cancer cell lines. However, following oral consumption exist mainly as inactive glucuronic acid conjugates with...