A5080048831- Phytoestrogen effects and research
- Biochemical Acid Research Studies
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Advanced Glycation End Products research
- Plant-derived Lignans Synthesis and Bioactivity
- Paraoxonase enzyme and polymorphisms
- Glycosylation and Glycoproteins Research
- Alcoholism and Thiamine Deficiency
- Bioactive Compounds and Antitumor Agents
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics, phytochemicals, and oxidative stress
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Neurological diseases and metabolism
- Plant Toxicity and Pharmacological Properties
- Coenzyme Q10 studies and effects
- Nutrition and Health in Aging
- Therapeutic Uses of Natural Elements
- Obesity, Physical Activity, Diet
- Vitamin C and Antioxidants Research
- Galectins and Cancer Biology
- Obesity and Health Practices
- Intensive Care Unit Cognitive Disorders
- Metabolism and Genetic Disorders
University of Saskatchewan
2003-2017
Saskatchewan Disease Control Laboratory
2014
Evidence from the literature suggests that dietary flaxseed lignans have ability to modulate inflammation, which is recognized as underlying basis of multiple chronic human diseases in older adults. Our objective was determine effects oral lignan supplementation on biochemical and functional indicators inflammation well safety tolerability healthy We designed a randomized, double-blind, placebo-controlled clinical trial adults (60–80 years) assess lignan–enriched complex (∼38%...
Context: The natural health product, BeneFlax, is a standardized flaxseed [Linum usitatissimum L. (Linaceae)] lignan enriched product with evidence of quality and known quantity the bioactive component, lignan. acceptance this for its various benefits requires greater safety in general population.Objective: We determined whether causes clinical hypoglycemia or hypotension healthy older adults as an important aspect safety.Materials methods: Participants aged 49–87 years were randomized...
The lignan meso-nordihydroguaiaretic acid is known to undergo spontaneous oxidation in alkaline solution. In the presence of trapping agent glutathione, major products are consistent with formation a ortho-quinone. absence however, product aqueous solution unique, stable schisandrin-like dibenzocyclooctadiene that may be responsible for some biological effects nordihydroguaiaretic acid.
Vitamin-mineral supplementation may offer older adults health and cognition-related benefits but overuse contribute to polypharmacy. We examined the prevalence of supplement usage in long-term care facility (LTC) residents (≥ 65 years age). As cognition be affected by nutrition, we also use those with diagnosis dementia no diagnosis. The overall "pill count" from pharmaceutical was assessed 189 LTC a subsample 56 diagnosis, respectively. Participants were residing an mid-size metropolitan...
The naturally occurring antioxidant lignan nordihydroguaiaretic acid has been used in traditional medicine to treat a variety of conditions and more recently investigated for its anticancer antimicrobial properties. Nordihydroguaiaretic also shown cause kidney toxicity rats there is evidence suggest that chronic consumption may liver humans. likely undergoes biotransformation reactive quinone species, either an ortho-quinone or para-quinone methide, which responsible toxicity. In effort...
(1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) synthase, or MenD, catalyzes the thiamin diphosphate- (ThDP-) dependent decarboxylation of 2-oxoglutarate, subsequent addition resulting succinyl-ThDP moiety to isochorismate, and δ-elimination pyruvate yield SHCHC, pyruvate, carbon dioxide. The enzyme is part a superfamily ThDP-dependent 2-oxo acid decarboxylases that includes decarboxylase, benzoylformate acetohydroxy among others. However, this only known catalyze...
Background: Increased oxidative stress and inflammation are associated with aging, contribute to an increased risk of chronic disease in older adults. Flaxseed lignans demonstrate antioxidant anti-inflammatory activity, but their ability reduce markers adult populations has received limited investigation. Objective: This is a intervention trial community-dwelling healthy adults examine the effects flaxseed lignan (secoisolariciresinol diglucoside; SDG) enriched supplement (BeneFlax) compared...
Long-term care (LTC) homes plan menus based on Eating Well with Canada's Food Guide (CFG) recommendations for older adults. To determine whether recommended CFG servings and nutrients were being provided, we analyzed the menu of a large LTC facility in metropolitan area compared our analysis similar one conducted 2000.A full week's from Saskatoon was recent Dietary Recommended Intake nutrient recommendations. The using Processor SQL. 2011 2000 to permit an evaluation changes over decade.The...
Chronic inflammation may promote the development of age related conditions such as dementia, osteoporosis, pain and frailty especially in long term care (LTC) residing older adults. Aim study was to determine associations between measures functionality, cognition LTC adults Saskatoon, SK Canada. Those 60–80 y residents LTCs, able satisfactorily comply with protocol requirements were enrolled. Blood draws (inflammatory cytokines, hs‐CRP, 25(OH)‐vitamin D, cholesterol prealbumin), vital signs,...