Nick de Jonge
A5076576350- Neutropenia and Cancer Infections
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Hematological disorders and diagnostics
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Oral health in cancer treatment
- Acute Lymphoblastic Leukemia research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Infectious Diseases and Mycology
- Hematopoietic Stem Cell Transplantation
- Central Venous Catheters and Hemodialysis
- Health Literacy and Information Accessibility
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Vascular Malformations and Hemangiomas
- Dermatological and COVID-19 studies
- Histiocytic Disorders and Treatments
Amsterdam University Medical Centers
2020-2024
Amsterdam UMC Location VUmc
2013-2024
Vrije Universiteit Amsterdam
2022-2024
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University of Rijeka
2023
Azienda Usl Toscana Centro
2023
Klinikum rechts der Isar
2023
University Medical Center Utrecht
2022
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2022
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics HM patients developing COVID-19 and analyzed predictors mortality. The survey was supported by the Scientific Working Group Infection Hematology European Association (EHA). Eligible analysis were adult laboratory-confirmed...
Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and between January 2021 March 2022 were analyzed. A total 1548 cases included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing 753 (49%), the Omicron variant was prevalent (517, 68.7%). Most received ≤2 vaccine doses before (1419, 91%), mostly...
Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management AML patients COVID-19 has not been established. Our multicenter study included 388 adult diagnosed between February 2020 and October 2021. vast majority were receiving or had received treatment in the preceding 3 months. was severe 41.2% critical 21.1% cases. chemotherapeutic schedule modified 174 (44.8%), delayed 68 permanently discontinued 106. After a...
Abstract Background Invasive aspergillosis (IA) by a triazole-resistant Aspergillus fumigatus is associated with high mortality. Real-time resistance detection will result in earlier initiation of appropriate therapy. Methods In prospective study, we evaluated the clinical value AsperGenius polymerase chain reaction (PCR) assay hematology patients from 12 centers. This PCR detects most frequent cyp51A mutations A. conferring azole resistance. Patients were included when computed tomography...
The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. aim present study was to retrospectively analyse the and risk factors for mortality a large series patients who developed infection after an HSCT.This multicenter retrospective promoted by European Hematology Association - Infections Study Working Group, included 326 adult HSCT had between January 2020 March 2022.The median time from diagnosis 268 days (IQR...
BackgroundThe COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, monoclonal antibodies have been effective the general population, their benefits these patients may not be as pronounced.MethodsThe EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers data from malignancy since pandemic's...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes life-threatening COVID-19 in hematologic malignancy (HM) patients, associated with high morbidity and mortality this particularly vulnerable population.1 After more than years since the beginning of pandemic, several prophylactic therapeutic strategies have been developed against SARS-CoV-2, including targeted antivirals, monoclonal antibodies vaccines, leading to improved prognosis HM patients.2 Our preliminary data...
Persistence of leukemic stem cells (LSC) after chemotherapy is thought to be responsible for relapse and prevents the curative treatment acute myeloid leukemia (AML) patients. LSC normal hematopoietic (HSC) share many characteristics co-exist in bone marrow AML For development successful LSC-targeted therapy, enabling eradication while sparing HSC, identification differences between HSC residing within crucial. these targets, as well characterization, discrimination imperative. Here we show...
To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates azole resistance among non-albicans spp. continue to increase. The objective this sub-analysis European multicenter observational cohort study III was describe demographical and clinical characteristics requiring prolonged hospitalization solely complete intravenous (iv) antifungal (AF Tx).Each participating hospital (number eligible hospitals per country determined by population...
// Xiaolu Zhang 1, * , Bingnan Li Nick de Jonge 1 Magnus Björkholm Dawei Xu Department of Medicine, Division Hematology and Center for Molecular Karolinska Institutet University Hospital Solna, Stockholm, Sweden These authors have contributed equally to this work Correspondence to: Xu, e-mail: Dawei.Xu@ki.se Keywords: AML, Apoptosis, DNMT inhibitors, Telomerase, Telomere, TERT Received: November 16, 2014 Accepted: December 14, Published: January 06, 2015 ABSTRACT DNA methyltransferase...
Our aim was to evaluate the effect of updated European Organization for Research and Treatment Cancer (EORTC) Mycoses Study Group 2019 definitions invasive pulmonary aspergillosis (IPA) on patient classification related all-cause 12-week mortality.In this retrospective cohort study from our tertiary care centre, we reclassified patients with haematological malignancy who underwent bronchoalveolar lavage between 2014 suspected IPA using novel EORTC criteria. We performed receiver operating...
Summary Patients with haematological malignancies are at risk for invasive fungal diseases ( IFD ). A survey was conducted in all Dutch academic haematology centres on their current diagnostic, prophylactic and therapeutic approach towards the context of azole‐resistance. In 8 centres, a haematologist microbiologist filled questionnaire that focused different subgroups patients. Fungal prophylaxis during neutropaenia directed against Candida consisted fluconazole and/or amphotericin B...
Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated targeted drugs laboratory-confirmed COVID-19 diagnosed between February 2020 January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than...
Since the beginning of COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates hospitalization, intensive care unit (ICU) admissions, and In comparison other patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large database (EPICOVIDEHA), demonstrated that majority CML...
We aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk line associated bloodstream infections (CLABSI) in haematology patients.Multicentre retrospective cohort study among patients receiving PICCs between 2013 and 2015. Occurrence CLABSI based on CDC definitions was assessed. calculated incidence rates, determined factors for used Poisson regression models the developing as a function PICC dwell time. compared diagnoses treatment...
In neutropenic patients, bloodstream infections (BSI) significantly contribute to morbidity and mortality. Appropriate empirical antibiotic therapy (EAT) of BSI is essential, at the same time overconsumption very broad-spectrum antibiotics should be avoided. We investigated: (1) whether surveillance cultures can predict with third-generation cephalosporin -resistant Enterobacterales Pseudomonas aeruginosa (3GC-R), (2) effect inappropriate antimicrobial (IEAT) on clinical outcome (3)...
Haematology patients with high-risk neutropenia are prone to mucosal-barrier injury-associated laboratory-confirmed bloodstream infections (MBI-LCBI). We assessed risk factors for MBI-LCBI including candidaemia in neutropenic haematology fever.
Abstract Objectives Among patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of gram-negative bacteria (GNB) to third-generation cephalosporins (3GC) increasing. In order explore the value using surveillance cultures guide empirical treatment e.g. choosing between carbapenem versus ceftazidime- we aimed assess distribution pathogens causing in and proportion 3GC-resistant GNB (3GC-R GNB) that was preceded by 3GC-R...