A5002700241- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fetal and Pediatric Neurological Disorders
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Blood disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Spinal Dysraphism and Malformations
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- Neonatal and Maternal Infections
- Neutropenia and Cancer Infections
- Autoimmune Bullous Skin Diseases
Washington University in St. Louis
2024
Erasmus MC
2019-2023
Erasmus University Rotterdam
2022
Erasmus MC - Sophia Children’s Hospital
2018
We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with 1 cohort mortality rates 43%-52%.
Abstract Background Invasive aspergillosis (IA) by a triazole-resistant Aspergillus fumigatus is associated with high mortality. Real-time resistance detection will result in earlier initiation of appropriate therapy. Methods In prospective study, we evaluated the clinical value AsperGenius polymerase chain reaction (PCR) assay hematology patients from 12 centers. This PCR detects most frequent cyp51A mutations A. conferring azole resistance. Patients were included when computed tomography...
Fast diagnosis of invasive pulmonary aspergillosis (IPA) is essential as early adequate therapy improves survival. However, current microbiological methods suffer from a low sensitivity or long turnaround time, often result batching. Recently, two lateral flow assays for diagnosing IPA have been CE (Conformité Européenne)-marked and commercialized. These can be used fast single sample testing. clinical validation comparative studies are lacking. We therefore sought to evaluate compare these...
Galactomannan (GM) testing of bronchoalveolar lavage (BAL) fluid samples has become an essential tool to diagnose invasive pulmonary aspergillosis (IPA) and is part diagnostic guidelines. Enzyme-linked immunosorbent assays (ELISAs) (enzyme immunoassays [EIAs]) are commonly used, but they have a long turnaround time. In this study, we evaluated the performance automated chemiluminescence immunoassay (CLIA) with BAL samples. This was multicenter retrospective study in Netherlands Belgium. were...
pneumonia (PCP) is an AIDS-defining illness. In patients with HIV, the benefit of PCP prophylaxis well-defined when CD4 T-cell count decreases below 200 cells/μL. other immunocompromised patients, value not always as well-established. This study aimed to describe epidemiology in recent years and assess how many did or receive month preceding infection.
Abstract Background Invasive pulmonary aspergillosis (IPA) is an increasingly recognized complication in intensive care unit (ICU) patients, especially those with influenza, cirrhosis, chronic obstructive disease, and other diseases. The diagnosis can be challenging, the ICU, where clinical symptoms as well imaging are mostly nonspecific. Recently, Aspergillus lateral flow tests were developed to decrease time of IPA. Several studies have shown promising results bronchoalveolar lavage fluid...
Invasive pulmonary aspergillosis (IPA) is a potentially lethal infection in patients with hematological diseases or following allogeneic stem cell transplantation. Early diagnosis essential, as delayed treatment results increased mortality. Recently, lateral flow device (LFD) for the of IPA was CE marked and made commercially available by OLM Diagnostics. We retrospectively analyzed bronchoalveolar lavage fluid (BALf) collected from adult hematology 4 centers The Netherlands Belgium....
To longitudinally study blood monocyte subset distribution and human leukocyte antigen-DR (HLA-DR) expression on subsets in children with sepsis, post-surgery trauma relation to nosocomial infections mortality.In 37 healthy critically ill (12 11 post-surgery, 10 4 admitted for other reasons)-participating a randomized controlled trial early versus late initiation of parenteral nutrition-monocyte HLA-DR were measured by flow cytometry upon admission days 2, 3 pediatric intensive care unit...
Compared with postnatal repair, prenatal myelomeningocele (MMC) repair is associated improved motor function and decreased need for cerebrospinal fluid (CSF) diversion. It unknown how surgery alters neuroanatomical structures identifiable on magnetic resonance imaging (MRI). The purpose of this study was to use MRI compare neurodevelopmental anatomy in patients undergoing fetal MMC compared those repair.
Induction chemotherapy for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) is almost universally complicated by febrile neutropenia(FN). Empirical broad-spectrum antibiotic therapy (EBAT) strategies advocated guidelines result in long periods of therapy. We compared the outcome AML/MDS patients treated with a 3-day versus prolonged (until neutrophil recovery) regimen.This retrospective comparative cohort study AML MDS undergoing remission-induction from 2011 to 2019, comparing...
Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 Objectives Prompt detection of azole-resistant Aspergillus fumigatus will result in the timely start active treatment and may improve survival invasive aspergillosis (IA). The use a multiplex polymerase chain reaction (PCR) targeting species DNA as well two most prevalent azole resistance- associated mutations (RAMs) cyp51A gen (TR34/L98H TR46/Y121F/T289A) could shorten time to detect IA. Methods In prospective study 12 Dutch...