A5025635874- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Palliative Care and End-of-Life Issues
- Neutropenia and Cancer Infections
- Vagus Nerve Stimulation Research
- Bacterial Identification and Susceptibility Testing
- Complement system in diseases
- Multiple Myeloma Research and Treatments
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Ethics in medical practice
- Retinoids in leukemia and cellular processes
- EEG and Brain-Computer Interfaces
- Anorectal Disease Treatments and Outcomes
Ghent University Hospital
2014-2025
Ghent University
2025
National Marrow Donor Program
2024
Universitair Ziekenhuis Brussel
2021-2024
Abstract Background Invasive aspergillosis (IA) by a triazole-resistant Aspergillus fumigatus is associated with high mortality. Real-time resistance detection will result in earlier initiation of appropriate therapy. Methods In prospective study, we evaluated the clinical value AsperGenius polymerase chain reaction (PCR) assay hematology patients from 12 centers. This PCR detects most frequent cyp51A mutations A. conferring azole resistance. Patients were included when computed tomography...
Abstract Lenalidomide, an antineoplastic and immunomodulatory drug, has therapeutic activity in acute myeloid leukemia (AML), but definitive studies about its utility have been lacking. In a phase 3 study, we compared 2 induction regimens newly diagnosed patients age 18 to 65 years with AML: idarubicine-cytarabine (cycle 1) daunorubicin intermediate-dose cytarabine 2) without or lenalidomide (15 mg orally on days 1-21). One final consolidation cycle of chemotherapy autologous stem cell...
An early diagnosis and treatment of invasive fungal disease (IFD) is associated with improved outcome, but the moderate sensitivity noninvasive diagnostic tests makes this challenging. Invasive procedures such as bronchoalveolar lavage (BAL) have a higher yield are not without risk. The detection sequencing microbial cell-free DNA (mcfDNA) may facilitate diagnosis. In prospective observational study, we collected plasma in 120 hours preceding or following BAL patients hematological...
The gut microbiota makes critical contributions to host homeostasis, and its role in the treatment of acute myeloid leukaemia (AML) has attracted attention. We investigated whether microbiome is affected by AML, such changes are associated with cachectic hallmarks. Biological samples clinical data were collected from 30 antibiotic-free AML patients at diagnosis matched volunteers (1:1) a multicenter cross-sectional prospective study. composition functional potential faecal analyzed using...
Guadecitabine is a novel hypomethylating agent (HMA) resistant to deamination by cytidine deaminase. Patients with relapsed/refractory acute myeloid leukemia (AML) were randomly assigned guadecitabine or preselected treatment choice (TC) of high-intensity chemotherapy, low-intensity HMAs low-dose cytarabine, best supportive care (BSC). The primary end point was overall survival (OS). A total 302 patients (n = 148) TC 154). Preselected TCs 233 [77%; mainly HMAs]), chemotherapy 63 [21%]), and...
Abstract Acute myeloid leukemia (AML) comprises 32% of adult cases, with a 5‐year survival rate only 20–30%. Here, the immunophenotypic landscape this heterogeneous malignancy is explored in single‐center cohort using novel quantitative computational pipeline. For 122 patients who underwent induction treatment intensive chemotherapy, leukemic cells were identified at diagnosis, computationally preprocessed, and quantitatively subtyped. Computational analysis provided broad characterization...
An accurate diagnosis of invasive aspergillosis (IA) in patients with underlying hematological malignancies relies heavily on galactomannan detection. In this study, we compared the VirCLIA chemiluminescence immunoassay (CLIA) frequently used Platelia enzyme-linked immunosorbent assay (ELISA) serum from hematology suspected IA. Patients were categorized according to EORTC/MSGERC 2020 definitions into proven/probable IA and possible/no The first cohort included 161 at four centers,...
Induction chemotherapy for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) is almost universally complicated by febrile neutropenia(FN). Empirical broad-spectrum antibiotic therapy (EBAT) strategies advocated guidelines result in long periods of therapy. We compared the outcome AML/MDS patients treated with a 3-day versus prolonged (until neutrophil recovery) regimen.This retrospective comparative cohort study AML MDS undergoing remission-induction from 2011 to 2019, comparing...
Abstract Background Vancomycin is a commonly prescribed antibiotic to treat gram-positive infections. The efficacy of vancomycin known be directly related the pharmacokinetic/pharmacodynamic (PK/PD) index area under concentration-time curve (AUC) divided by minimal inhibitory concentration (MIC) pathogen. However, in most countries, steady-state plasma concentrations are used as surrogate parameter target AUC/MIC, but this practice has some drawbacks. Hence, direct AUC-guided monitoring...
Treatment results of AML in elderly patients are unsatisfactory. We hypothesized that addition tosedostat, an aminopeptidase inhibitor, to intensive chemotherapy may improve outcome this population. After establishing a safe dose run-in phase the study 22 patients, 231 eligible with above 65 years age (median 70, range 66–81) were randomly assigned open label randomized Phase II receive standard (3+7) or without tosedostat at selected daily 120 mg (n = 116), days 1–21. In second cycle,...
Immunotherapeutic strategies targeting the rare leukemic stem cell compartment might provide salvage to high relapse rates currently observed in acute myeloid leukemia (AML). We applied gene expression profiling for comparison of blasts and cells with their normal counterparts. Here, we show that T-cell receptor γ chain alternate reading frame protein (TARP) is over-expressed de novo pediatric (n=13) adult (n=17) AML sorted compared hematopoietic myeloblasts (15 healthy controls). Moreover,...
Abstract Background Invasive pulmonary aspergillosis (IPA) is a relatively common infection in patients with acute myeloid leukaemia (AML), and associated high mortality rates. Optimising early detection key to reduce the burden of IPA this population. In retrospective cohort study, we evaluated added value baseline chest CT before start classical induction chemotherapy. Methods Adult receiving first‐line intensive chemotherapy for AML were included if scan was available (±7 days). Data...
The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring therapy when resistance unknown. low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints enhance efficiency.