A5069800727- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Drug-Induced Adverse Reactions
- Urinary Bladder and Prostate Research
- Infective Endocarditis Diagnosis and Management
- Neutropenia and Cancer Infections
- Antibiotic Resistance in Bacteria
- Urticaria and Related Conditions
- Pharmacovigilance and Adverse Drug Reactions
- Streptococcal Infections and Treatments
- Meta-analysis and systematic reviews
- Patient Satisfaction in Healthcare
- Pediatric Urology and Nephrology Studies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Clinical Reasoning and Diagnostic Skills
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Sepsis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Contact Dermatitis and Allergies
- Clostridium difficile and Clostridium perfringens research
Leiden University Medical Center
2016-2025
Leiden University
2020-2022
Rijnland Ziekenhuis
2011
Sophia Revalidatie
2010
Isala
2010
Geneeskundige en Gezondheidsdienst
2009
Pre-existing lower urinary tract symptoms (LUTS), cognitive impairment, and the high prevalence of asymptomatic bacteriuria (ASB) complicate diagnosis infection (UTI) in older women. The presence pyuria remains cornerstone UTI diagnosis. However, >90% ASB patients have pyuria, prompting unnecessary treatment. We quantified by automated microscopy flowcytometry to determine diagnostic accuracy for derive thresholds women.Women ≥65 years with ≥2 new-onset LUTS 1 uropathogen ≥104 colony-forming...
Background Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is unlikely if blood have been negative for 48–72 hours. Modern BC systems reduced this time-to-positivity (TTP), questioning whether time frame of hrs still valid. This study investigates distribution TTP, probability culture positivity after 24 hours, and identifies predictors prolonged TTP. Methods Adult patients with...
Abstract Background Despite being the leading cause of mortality from bloodstream infections worldwide, little is known about regional variation in treatment practices for Staphylococcus aureus bacteremia (SAB). The aim this study was to identify global management, diagnostics, and definitions SAB. Methods During a 20-day period 2022, physicians throughout world were surveyed on SAB practices. survey distributed through listservs, e-mails, social media. Results In total, 2031 71 different...
Abstract Purpose Although [18F]-FDG-PET/CT scanning (PET/CT) is recommended for managing Staphylococcus aureus bacteremia (SAB), its added value remains debated. This study investigated the clinical revenues of selective PET/CT use in SAB by considering three consequence-categories: detection new infection foci, performance interventions, and alterations antimicrobial therapy. Methods All adult patients with ≥ 1 blood culture (BC) positive admitted a Dutch academic center between 2017 11...
Timely empiric antimicrobial therapy is one of the cornerstones management suspected bloodstream infection (BSI). However, studies about effects on mortality have reported inconsistent results. The objective this study was to estimate effect delay appropriate early in patients with BSI. Methods: Data for propensity score matching (PSM) were obtained from a cohort Inadequate treatment defined as vitro resistance regimen administered <6 h after blood cultures taken. primary outcome measure...
Urinary tract infection (UTI) is common among older women. However, diagnosis challenging because of frequent chronic lower urinary symptoms, cognitive impairment, and a high prevalence asymptomatic bacteriuria (ASB). Current urine diagnostics lack specificity, leading to unnecessary treatment antimicrobial resistance. This study aimed evaluate the diagnostic accuracy 12 biomarkers for diagnosing UTI in
Recurrent urinary tract infections (UTIs) are common, especially in women. When oral antimicrobial prophylaxis is ineffective or not possible due to allergies resistance, intravesical aminoglycoside instillations (IAIs) a non-systemic alternative.To assess treatment satisfaction, long-term safety and efficacy of IAIs for recurrent UTI.We conducted cohort study using data collected between January 2013 June 2022 at the Leiden University Medical Center. Adult patients with UTI who received...
Methicillin-resistant Staphylococcus aureus (MRSA) colonization increases the risk of infection. Response to decolonization treatment is highly variable and determinants for successful or failure eradication are largely unknown. Insight into genetic predictors potentially useful in clinical practice. The aim this study was explore characteristics that associated with MRSA failure. This cohort performed a tertiary care hospital Netherlands. Patients ≥ 1 positive culture from any site...
Abstract Objectives Blood cultures ( BC s) are essential in the evaluation of neutropenic fever. Modern systems have significantly reduced time‐to‐positivity TTP ) . This study explores probability bacteraemia when s remained negative for different periods time. Methods All adult patients with neutropenia and were included (January 2012‐February 2016). Predictive clinical factors short (≤16 hours) long (>24 determined. The residual was estimated scenario 24 hours after collection. Results...
Methicillin-resistant Staphylococcus aureus (MRSA) colonization leads to increased infection rates and mortality. Decolonization treatment has been proven prevent reduce transmission. As the optimal antimicrobial strategy is yet be established, different regimens are currently prescribed patients. This study aimed evaluate efficacy of decolonization treatments recommended by Dutch guideline. A retrospective multicenter cohort was conducted in five hospitals. All patients who visited...
From a stewardship perspective it is recommended that antibiotic guidelines are adjusted to the local setting, accounting for epidemiology of pathogens. In many settings prevalence Gram-negative pathogens with resistance empiric sepsis therapy increasing. How and when escalate standard reserve antimicrobial agent, recurrent dilemma. The study objective was develop decision strategies based on microbiological clinical data, estimate number needed treat carbapenem avoid mismatch in one patient...
ObjectivesThe association of biological female sex with outcome in patients Staphylococcus aureus bacteremia remains unresolved. The aim this study was to determine the independent management and mortality S. bacteremia.MethodsThis is a post-hoc analysis prospectively collected data from Bacteremia Group Prospective Cohort Study. Adult monomicrobial at Duke University Medical Center were enrolled 1994 2020. Univariable multivariable Cox regression analyses performed assess differences...
A cornerstone in the management of Staphylococcus aureus bacteraemia (SAB) is differentiation between a complicated and an uncomplicated SAB course. The ability to early accurately identify patients with - without may optimise utility diagnostics prevent unnecessary prolonged antibiotic therapy.Development validation prediction score using demographic, clinical, laboratory data from two independent Dutch cohorts; estimating risk disease at time first positive blood culture. Models were...
BackgroundIsolation precautions are applied to control the risk of transmission multi-drug resistant organisms (MDROs). These have been associated with adverse effects, such as anxiety and depression. This study aimed quantify stigma among MDRO carriers its association perceived mental health experienced quality care.MethodsA quantitative questionnaire was performed in exposed ≥3 days isolation during hospitalization. Items derived from Consumer Quality Index (CQI) were used assess...
Background Approximately 2% of patients in primary care practice and up to 25% hospital are registered as being allergic an antibiotic. However, 90% these registrations incorrect, leading unnecessary prescription 2 nd choice antibiotics with the attendant loss efficacy, increased toxicity antibiotic resistance. To improve registration, a better understanding is needed how incorrect labels attributed. Objective investigate quality allergy registration identify determinants allergies. Design...