Toni Valković
A5004386664- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Bone health and treatments
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Hemoglobinopathies and Related Disorders
- Cancer, Lipids, and Metabolism
- Bone and Dental Protein Studies
- Iron Metabolism and Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer-related cognitive impairment studies
University of Rijeka
2015-2025
Croatian Chamber of Economy
2021-2024
Università della Svizzera italiana
2023
Azienda Usl Toscana Centro
2023
Klinikum rechts der Isar
2023
Klinički Bolnički Centar Rijeka
2010-2022
University of Zagreb
2021
University of Padua
2020
University Hospital Centre Zagreb
2010-2019
University Clinical Hospital Mostar
2018
Objective: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series patients with early-onset (<50 years) parkinsonism. Methods: The authors studied 134 (116 sporadic 18 familial; 77% Italian) 90 Italian controls. whole coding region was sequenced from genomic DNA; cDNA analyzed selected cases. Results: Homozygous pathogenic were identified 4 cases, including novel Gln456Stop mutation; single heterozygous truncating or missense found another two...
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics HM patients developing COVID-19 and analyzed predictors mortality. The survey was supported by the Scientific Working Group Infection Hematology European Association (EHA). Eligible analysis were adult laboratory-confirmed...
Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and between January 2021 March 2022 were analyzed. A total 1548 cases included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing 753 (49%), the Omicron variant was prevalent (517, 68.7%). Most received ≤2 vaccine doses before (1419, 91%), mostly...
BackgroundThe COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, monoclonal antibodies have been effective the general population, their benefits these patients may not be as pronounced.MethodsThe EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers data from malignancy since pandemic's...
Multiple myeloma is among the most common hematological malignancies and characterized by a strong susceptibility to infections primarily bacterial viral and, much lesser extent, fungal. There appears be slightly increasing frequency of invasive fungal infections. This attributed use different combinations newer drugs patients’ exposure therapeutic lines, thus risk factors for infections, especially severe long-term neutropenia. Novel immunotherapy modalities including bispecific antibodies...
Multiple myeloma (MM) is predominantly a disease of the elderly, but approximately 10% patients are younger than 50 years at diagnosis. METHODS: This study aimed to investigate clinical characteristics, treatment outcomes, and prognostic factors in MM using retrospective data from Balkan Myeloma Study Group registry. RESULTS: A total 350 under old were included, comprising 10.4% overall cohort. The found that had lower rates renal impairment anemia higher incidence lytic bone adverse...
Carfilzomib-based regimens brought a significant improvement in the treatment of relapsed/refractory multiple myeloma (RRMM). Even though efficacy and safety profiles carfilzomib are well-established several clinical trials, there is limited real-world data with carfilzomib-based protocols. Here we present our experience for patients RRMM Croatia. Data on starting protocols period between June 2019 February 2023 was collected by retrospective chart review from 14 Croatian centres. A total...
Abstract Background Estimation of plasma cell infiltrates in bone marrow aspirates (BMA) and biopsy (BMB) is a standard method the diagnosis monitoring multiple myeloma (MM). Plasma fraction therefore critical for classification optimal clinical management patients with dyscrasias. The aim study was to compare percentage cells obtained by both methods patient parameters survival. Methods This retrospective included BMA BMB 59 MM patients. conventional differential count determined estimate...
Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.We analyzed elderly (age groups: 65-70, 71-75, 76-80, and >80 years old) included EPICOVIDEHA registry between January 2020 July 2022. Univariable multivariable Cox regression models were conducted to identify factors influencing death hematological malignancy.The study data from 3,603 (aged 65 or older) malignancy, a...
Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent (20)19 disease (COVID-19)-related death. The changing epidemiological therapeutic scenarios suggest that there has been improvement in severity survival COVID-19 during the different waves pandemic general population, but this not investigated yet MM patients. Here we analyzed a large cohort 1221 patients with confirmed SARS-CoV-2...
Early intervention with nutritional supplementation has been shown to halt malnutrition and may improve outcome in some patients colorectal cancer. The aim of this study was investigate whether dietary counseling, oral nutrition megestrol acetate during chemotherapy affected status survival advanced disease.Six hundred twenty-eight disease were included the from January 2000 through December 2009 divided into one two groups. Group I consisted 315 who monitored prospectively given support. II...
Multiple myeloma is a common haematological malignancy and immune dysfunction the hallmark of disease. It leads to an increased infection risk, which still major cause mortality. The spectrum characteristics have evolved with introduction novel agents. An understanding risk factors that increase susceptibility infections critical in fighting them. This retrospective investigation aimed establish incidence main non-transplanted hospitalised patients our department over 3-year period, as well...
Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated targeted drugs laboratory-confirmed COVID-19 diagnosed between February 2020 January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than...
The aim of our study was to emphasize the importance accurate and standardized techniques for detailed monitoring microenvironment in multiple myeloma (MM). Bone marrow fibrosis, angiogenesis, plasma cell infiltrates bone biopsy (BMB) samples at time diagnosis on completion therapy were analyzed 42 patients with newly diagnosed MM. Computerized image analysis used all slides stained anti-CD138 anti-CD34. fibrosis pretreatment BMB had significantly higher microvessel density (MVD)...
Patients with lymphoid malignancies are at increased risk of death or prolonged infection due to COVID-19. Data on the influence different antineoplastic treatment modalities outcomes conflicting. Anti-CD20 monoclonal antibodies increase infection. It is unclear whether this affected by choice antibody (rituximab vs. obinutuzumab). To elucidate role therapy COVID-19 outcomes, KroHem collected data patients diagnosed between October 2020 and April 2021. A total 314 were identified, 75...
Abstract Objectives To explore the impact of sex and age on relationship between prodromal constipation disease phenotype in Parkinson’s at early stages. Methods A total 385 patients from PRIAMO study were classified according to presence followed for 24 months. Multivariable mixed-effect models applied. All analyses performed separately (64.1% men) median (different by sex: 67 years-old men 68 women). Results As sex, was associated with greater odds attention/memory complaints apathy...