A5029941373- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Bone and Dental Protein Studies
- Angiogenesis and VEGF in Cancer
- Cutaneous Melanoma Detection and Management
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Cutaneous lymphoproliferative disorders research
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Bone health and treatments
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Breast Cancer Treatment Studies
- Oral and Maxillofacial Pathology
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Soft tissue tumor case studies
University of Rijeka
2016-2025
University Hospital Centre Zagreb
1999-2025
Klinički Bolnički Centar Rijeka
2021
Mario Negri Institute for Pharmacological Research
1992
Tumor-promoted constraints negatively affect cytotoxic T lymphocyte (CTL) trafficking to the tumor core and, as a result, inhibit killing. The production of reactive nitrogen species (RNS) within microenvironment has been reported in mouse and human cancers. We describe novel RNS-dependent posttranslational modification chemokines that profound impact on leukocyte recruitment tumors. Intratumoral RNS induces CCL2 chemokine nitration hinders cell infiltration, resulting trapping...
The mesothelium is a flat epithelial lining of serous cavities that could gate the traffic molecules and cells between circulation these body compartments. present study was designed to elucidate capacity mesothelial express adhesion chemoattractant cytokines, two fundamental mechanisms regulation leukocyte recruitment. Cultured human appreciable levels intercellular molecule 1 (ICAM-1) vascular cell (VCAM-1), were increased by in vitro exposure tumor necrosis factor (TNF), interferon gamma...
Summary Cytokines play important roles in the pathogenesis of lymphomas. This study aimed to determine relationship(s) between serum levels interleukin (IL)‐6, IL‐8 and IL‐10, measured by enzyme‐immunoassay, clinical characteristics outcomes 46 untreated patients with diffuse large B‐cell lymphoma (DLBCL). Serum IL‐6, IL‐10 were higher DLBCL than control subjects. Elevated correlated more adverse disease features. Consequently, elevated prior treatment had a lower response therapy....
Abstract Background The role of angiogenesis in the pathogenesis renal cell carcinoma is well recognized, however, influence tumor cells this activity has not yet been fully clarified. aim study was to analyze expression hypoxia inducible factor-1α (HIF-1α), a regulatory factor angiogenic switch, comparison vascular endothelial growth A and C (VEGF-A VEGF-C), recognized be involved blood lymph vessel neoangiogenesis, with potential association prognosis patients carcinoma. Methods...
Abstract Background Estimation of plasma cell infiltrates in bone marrow aspirates (BMA) and biopsy (BMB) is a standard method the diagnosis monitoring multiple myeloma (MM). Plasma fraction therefore critical for classification optimal clinical management patients with dyscrasias. The aim study was to compare percentage cells obtained by both methods patient parameters survival. Methods This retrospective included BMA BMB 59 MM patients. conventional differential count determined estimate...
Our study was designed to investigate the surface molecules involved in adhesion and cytotoxicity of activated human monocytes on resting IL-1-stimulated endothelial cells (EC). Monocytes, exposed prototypic activating stimuli IFN-gamma LPS, showed increased binding IL-1-treated EC. Activated were cytotoxic for EC a 24- 48-h [3H]TdR release assay. Anti-CD18 mAb significantly inhibited EC: particular they caused 59 22% inhibition EC, respectively. Anti-VLA4 had little or no effect when used...
Aims and background The p53 protein is essential for the regulation of cell proliferation its aberrant accumulation usually seen in malignant tumors but also occurs squamous epithelium inflammatory skin diseases characterized by hyperproliferation. aim this study to elucidate role tumor suppressor pathogenesis different hyperproliferative, non-malignant diseases, determine association between overexpression proliferation. We investigated influence aging on Ki-67 expression. Methods One...
The aim of this study was to analyze the association between vascular endothelial growth factor (VEGF) expression on tumor cells and other clinicopathologic parameters in breast cancer that could give additional information its prognostic significance. Immunohistochemical analysis VEGF, estrogen (ER) progesterone receptor (PR), HER-2/neu, Ki67 performed 233 cancers. VEGF estimated semiquantitatively correlated with all above-mentioned as well characteristics such menopausal status patients,...
Abstract Background The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis progression various malignant tumors has long been known, but there is still disagreement concerning prognostic significance EGFR expression clear cell renal carcinoma (CCRCC). present study was designed to analyze more objectively protein CCRCC compare value with gene copy number changes clinicopathologic characteristics including patient survival. Methods analyzed immunohistochemically...
The aim of this report is to present a case patient with recurrent nasal cavity amelanotic melanoma (AM), emphasis on diagnosis and therapy options clinical entity. A 65-year-old female presented pain in the right cheek region obstruction. In 2013, she was diagnosed mucosal (MM) left cavity. After endoscopic surgery radiotherapy, followed by oncology team. Five years after initial diagnosis, rhinoscopy showed tumorous formation tumor mass without black discoloration same color as surrounding...
The aim of our study was to emphasize the importance accurate and standardized techniques for detailed monitoring microenvironment in multiple myeloma (MM). Bone marrow fibrosis, angiogenesis, plasma cell infiltrates bone biopsy (BMB) samples at time diagnosis on completion therapy were analyzed 42 patients with newly diagnosed MM. Computerized image analysis used all slides stained anti-CD138 anti-CD34. fibrosis pretreatment BMB had significantly higher microvessel density (MVD)...
AimTo evaluate whether tumor infiltrating lymphocytes (TIL) in biopsy specimens are associated with the clinical outcome of non-muscle invasive bladder cancer.MethodsWe retrieved from 115 patients solitary papillary cancer treated between 1996 and 2006 constructed tissue microarrays. Patients were divided two groups: those recurrent disease (N = 69) without 46) during follow up minimum 5 years. All initial transurethral resection none received adjuvant therapy. Immunhistochemical staining...