A5040066504- Occupational and environmental lung diseases
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Trace Elements in Health
- Nanoparticles: synthesis and applications
- Soft tissue tumor case studies
- History of Medicine Studies
- Oral and Maxillofacial Pathology
- Radioactivity and Radon Measurements
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Nonmelanoma Skin Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Angiogenesis and VEGF in Cancer
- Tumors and Oncological Cases
- Medicine and Dermatology Studies History
- X-ray Spectroscopy and Fluorescence Analysis
- Head and Neck Surgical Oncology
- Genetic and rare skin diseases.
- Breast Lesions and Carcinomas
University of Trieste
2012-2023
Azienda Sanitaria Universitaria Integrata di Trieste
2001-2020
Ospedale di Cattinara
2008-2019
Ospedale di Monfalcone
2009-2011
Istituti di Ricovero e Cura a Carattere Scientifico
2009
National Institute of Health
2009
Centro di Riferimento Oncologico
2009
Ospedale Maggiore
2001-2005
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2005
Wilford Hall Ambulatory Surgical Center
2002
Glucocorticoids (GCs) have been shown to reduce mortality and the need for invasive mechanical ventilation (IMV) in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS). It has suggested that serum cytokines levels are markers of disease severity ARDS, although there is only limited evidence a relationship between longitudinal cytokine profile clinical outcomes patients with ARDS treated GC.We conducted single-center observational study investigate serial plasma 17 supported...
Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. toxicity ascribed to particular physico-chemical characteristics one of them the presence ability adsorb iron, which may cause an alteration iron homeostasis in tissue. This observational study reports combination advanced synchrotron-based X-ray imaging micro-spectroscopic methods that provide correlative morphological chemical information for...
The salivary glands, despite their relatively simple morphology, give rise to more than 30 histologically distinct benign and malignant tumors. Salivary gland neoplasms comprise less 2% of all tumors in humans 3% head neck They arise the parotid 80% cases, approximately are 20% malignant. Among them lymphoepithelial lesions, rare lesions glands especially that characterized by lymphocytic infiltration associated with an epithelial proliferation. divided into benign, which is considered as a...
We report on the use of UV Raman technique to monitor oxidative damage deoxynucleotide triphosphates (dATP, dGTP, dCTP and dTTP) DNA (plasmid vector) solutions. Nucleotide aqueous solutions were exposed hydrogen peroxide (H2O2) iron containing carbon nanotubes (CNTs) produce Fenton's reaction induce damage. spectroscopy is shown be maximally efficient reveal changes in nitrogenous bases during mechanisms occurring these molecules. The analysis spectra, supported by numerical computations,...
Occupational or environmental exposure to asbestos fibres is associated with pleural and parenchymal lung diseases. A histopathologic hallmark of the presence in parenchyma so-called bodies. They are final product biomineralization processes resulting deposition endogenous iron organic matter (mainly proteins) around inhaled fibres. For shedding light on formation mechanisms bodies it fundamental importance characterize at same length scales not only their structural morphology chemical...
Starting from the observation that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/ Apo-2L protein is expressed in both malignant and inflammatory cells some highly vascularized soft tissue sarcomas, angiogenic potential of TRAIL was investigated a series vitro assays. Recombinant soluble induced endothelial cell migration vessel tube formation to degree comparable vascular growth factor (VEGF), one best-characterized factors. However, proangiogenic activity not mediated by...
It has been recently demonstrated that the internal jugular vein may exhibit abnormalities classified as truncular venous malformations (TVMs). The investigation of possible morphological and biochemical anomalies at tissue level could help to better understand link between brain drainage neurodegenerative disorders, found associated with TVMs. To this end we performed sequential X-ray Fluorescence (XRF) analyses on samples from two TVM patients control subjects, using complementary energies...
Poly-lactide-co-glycolide (PLGA) is one of the few polymers approved by US Food and Drug Administration as a carrier for drug administration in humans; therefore, it most used materials formulation polymeric nanoparticles (NPs) therapeutic purposes. Because cellular uptake NPs hot topic nanomedicine field, development techniques able to ensure incontrovertible evidence presence cells plays key role gaining understanding their potential. On strength this premise, article aims evaluate...
An increasing incidence of osteonecrosis the jaws (ONJ) in patients treated with intravenous bisphosphonates has been reported literature. The aim this study was to evaluate clinical aspects, diagnostic investigations, and management ONJ associated a series 12 patients.Our included 1 asymptomatic 11 symptomatic subjects. For patients, diagnosed through histological investigations exposed bone that showed avascular necrotic tissue inflammatory infiltrate. were complaining swelling, fever,...
Abstract Environmental and occupational inhalants may induce a large number of pulmonary diseases, with asbestos exposure being the most risky. The mechanisms are clearly related to chemical composition physical surface properties materials. A combination X-ray fluorescence (μXRF) Fourier Transform InfraRed (μFTIR) microscopy was used chemically characterize compare bodies versus environmental particulates (anthracosis) in lung tissues from exposed control patients. μXRF analyses revealed...
Carbon nanotubes (CNTs) are promising products in industry and medicine, but there several human health concerns since their fibrous structure resembles asbestos. The presence of transition metals, mainly iron, the fibres seems also implicated pathogenetic mechanisms. To unravel role iron at mesothelial level, we compared chemical changes induced MeT-5A cells by exposure to asbestos (crocidolite) or CNTs different content impurities (raw-SWCNTs, purified- highly purified-SWCNTs). We applied...
We report on a case of peculiar tumor the pilosebaceous unit showing composite histologic appearance. The presented as pigmented crusted lesion back nose 62-year-old woman with markedly sun-damaged skin. Histologically, superficial portion neoplasm was composed buds and nests basaloid epithelium varying degrees pilar sebaceous differentiation. Adjacent to this component, lobules squamous cells cytoplasmic glycogenation suggesting mature outer root sheath were seen. In underlying dermis,...
Abstract To assess the presence of SV40 in malignant mesothelioma tissue, 19 formalin-fixed paraffin-embedded pleural cancer samples patients from a hyperendemic area northeastern Italy were analyzed retrospectively. A total 48 other tissues subjects investigated. The load was determined by real-time quantitative PCR. Exposure to asbestos evaluated through careful review occupational history patients, supplemented histology and isolation bodies. Three (15.8%) harbored genomic signals. Two...
Abstract Background. Defects in the mitotic spindle checkpoint have been proposed to contribute chromosomal instability observed human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of checkpoint, whose role carcinogenesis still needs be clarified. Methods. We analyzed expression 49 cases OSCC by immunohistochemistry and compared findings with clinicopathologic parameters, proliferative activity, DNA ploidy. Results. was overexpressed 11 (22.4%). Tumors...
To dissect the effect of hyperinsulinemia versus hyperglycemia on TNF-related apoptosis inducing ligand (TRAIL) expression in macrovascular district, we measured TRAIL mRNA and protein four groups animals: streptozotocin (SZT)-induced diabetic rats, vehicle-treated control animals, rats treated with insulin non-diabetic insulin. While aortas did not show significant differences respect to both vivo for 16 days showed a decrease either rats. Moreover, vitro treatment rat human vascular smooth...
The role of asbestos bodies (and associated proteinacious coating) in diseases is not well understood. Currently employed methods isolation these employ harsh chemicals that lead to destruction their coating. In this work a method was developed enabled the purification whole, integral, unmodified (AB) by exploiting magnetic properties. Albumin and ferritin were found be major proteins with AB isolated from lung tissue mesothelioma patients. Magnetically shown cytotoxic activate free radical...
Abstract Asbestos bodies are the histological hallmarks of asbestos exposure. Both conventional and advanced techniques used to evaluate abundance composition in samples. We previously reported possibility using synchrotron X-ray fluorescence microscopy (XFM) for analyzing chemical directly lung tissue Here we applied a high-performance (XRF) set-up that could allow new protocols fast monitoring occurrence large sections, improving investigation related changes. A combination transmission at...