A5026204894- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Breast Lesions and Carcinomas
- Occupational and environmental lung diseases
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Digital Radiography and Breast Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- AI in cancer detection
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
Ospedale di Cattinara
2016-2025
University of Trieste
2016-2025
Azienda Sanitaria Universitaria Integrata di Trieste
2011-2024
University of Padua
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2019
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2019
The University of Texas MD Anderson Cancer Center
2018
Creative Research Enterprises (United States)
2018
University of Udine
2017
Azienda Ospedaliero Universitaria Ospedali Riuniti
2016
BackgroundCOVID-19 is a deadly pulmonary disease with peculiar characteristics, which include variable clinical course and thrombophilia. A thorough understanding of the pathological correlates still missing.MethodsHere we report systematic analysis 41 consecutive post-mortem samples from individuals who died COVID-19. Histological complemented by immunohistochemistry for cellular viral antigens detection genomes in situ RNA hybridization.FindingsCOVID-19 characterized extensive alveolar...
The authors evaluated the effect on mammographic examinations of use synchrotron radiation to detect phase-perturbation effects, which are higher than absorption effects for soft tissue in energy range 15–25 keV. Detection was possible because high degree coherence sources. Synchrotron images were obtained a phantom and vitro breast specimens compared with conventional studies. On basis grades assigned by three reviewers, image quality former considerably higher, delivered dose fully compatible.
Phase contrast x-ray imaging is a powerful technique for the detection of low-contrast details in weakly absorbing objects. This method possible relevance field diagnostic radiology. In fact, within soft tissue does not give satisfactory results conventional absorption radiology, mammography being typical example. Nevertheless, up to now all applications phase technique, carried out on thin samples, have required radiation doses substantially higher than those delivered radiological...
To prospectively evaluate the diagnostic contribution of mammography with synchrotron radiation in patients questionable or suspicious breast abnormalities identified at combined digital (DM) and ultrasonography (US).The ethics committee approved this prospective study, written informed consent was obtained from all patients. Mammography performed a phase-detection technique laboratory. Forty-nine women who met least one inclusion criteria (palpable mass, focal asymmetry, architectural...
Pre-symptomatic screening of genetic alterations might help identify subpopulations individuals that could enter into early access prevention programs. Since liquid biopsy is minimally invasive it can be used for longitudinal studies in healthy volunteers to monitor events progression from normal tissue pre-cancerous and cancerous condition. Yet, cell-free DNA (cfDNA) analysis comes with substantial challenges such as the lack large cohort addressing impact mutations or low abundance cfDNA...
Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- second-line settings. However, only 15-20% patients benefit from this treatment, a feature increasingly ascribed to peculiar characteristics tumor immune microenvironment (TIME).
At the SYnchrotron Radiation for MEdical Physics (SYRMEP) beamline of Elettra Synchrotron Light Laboratory in Trieste (Italy), an extensive research program bio‐medical imaging has been developed since 1997. The core carried out by SYRMEP collaboration concerns use (SR) clinical mammography with aim improving diagnostic performance conventional technique. first protocol patients, started 2006 completed at end 2009 and data analysis is now progress.
The aim of the SYRMA-CT collaboration is to set-up first clinical trial phase-contrast breast CT with synchrotron radiation (SR). In order combine high image quality and low delivered dose a number innovative elements are merged: CdTe single photon counting detector, state-of-the-art reconstruction phase retrieval algorithms. To facilitate an accurate exam optimization, Monte Carlo model was developed for calculation using GEANT4. this study, isotropic spatial resolution (120 μm)3 scans...
Background . Radiofrequency ablation (RFA) has been recently advocated as an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent it may affect any subsequent surgery and/or histological diagnosis. Materials and Methods RFA was performed on 64 Thy2 nodules (benign nodules) 6 Thy3 (follicular lesions/follicular neoplasms). Two regrew after procedure, these patients accepted undergo a total thyroidectomy. Here we present how affected...
Tumor organoids are tridimensional cell culture systems that generated in vitro from surgically resected patients’ tumors. They can be propagated maintaining several features of the tumor origin, including cellular and genetic heterogeneity, thus representing a promising tool for precision cancer medicine. Here, we established patient-derived (PDOs) different breast subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched, triple negative). The model showed...
The contribution of the complement system in pathophysiology brain cancers has been recently considered light its well-known involvement carcinogenesis. Complement represents an important component inflammatory response and acts as a functional bridge between innate adaptive immune response. C1q, first recognition subcomponent classical pathway, shown to be involved range pathophysiological functions that are not dependent on activation. C1q is expressed microenvironment various types human...
C1q is the first subcomponent of classical pathway complement system and belongs to C1q/Tumour Necrosis Factor superfamily. In addition, can perform a diverse range immune non-immune functions in complement-dependent as well -independent manner. Being charge pattern recognition molecule innate immunity, recognise number self, non-self altered-self ligands bring about effector mechanisms designed clear pathogens via opsonisation inflammatory response. locally synthesised by macrophages...
<b>Pneumomediastinum is a rare complication of ARDS but more common during #COVID19. The fibrous hyaline degeneration the tracheal rings seen in this autoptic series an original observation that has not been previously described COVID-19 patients.</b>https://bit.ly/3vxTQde
The measurement of the linear attenuation coefficients breast tissues is fundamental importance in field x-ray diagnostic imaging. Different groups have evaluated by carrying out direct measurements which specimens were thin and selected as homogeneous possible. Here, we use monochromatic high-intensity synchrotron radiation computed tomography (SR CT) to evaluate surgical energy range from 15 26.5 keV. X-ray detection performed a custom digital silicon micro-strip device, developed...
The aim of this study was to evaluate a novel animal model bisphosphonates-associated osteonecrosis, which realistically recapitulates the same pathological human condition. Five Wistar rats were given intravenous zoledronic acid 0.04 mg once week for 5 weeks. After 2 weeks, animals underwent extraction an upper molar, producing 4 mm-diameter bone defect on site. 7 weeks from extraction, clinically examined and scintigraphy carried out. additional week, killed both Computerized Tomography...
Formalin-fixed tissues represent the most abundant clinical material for retrospective studies. However, formalin highly affects macromolecules, impairing their extraction and analysis. In this study, suitability of some potential substitutes RNA-based applications has been considered. Conventional was compared with methacarn commercial FineFIX. Their impact on overall RNA preservation investigated in a cell line-based model fixed during time course treatment series human tissues. yield...
In prostate adenocarcinoma, the dissection of expression behaviour eukaryotic elongation factors (eEF1A1/2) has not yet fully elucidated.The EEF1A1/A2 expressions were investigated by real-time PCR, western blotting (cytoplasmic and cytoskeletal/nuclear-enriched fractions) immunofluorescence in androgen-responsive LNCaP non-responsive DU-145 PC-3 cells, displaying a low, moderate high aggressive phenotype, respectively. Targeted experiments also conducted 22Rv1, cell line marking progression...