A5064293036- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Advanced X-ray Imaging Techniques
- Digital Radiography and Breast Imaging
- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Advanced Semiconductor Detectors and Materials
- Radiation Shielding Materials Analysis
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- CCD and CMOS Imaging Sensors
- X-ray Spectroscopy and Fluorescence Analysis
- X-ray Diffraction in Crystallography
- Advanced Electron Microscopy Techniques and Applications
- Laser-Plasma Interactions and Diagnostics
- Radiation Therapy and Dosimetry
- Luminescence Properties of Advanced Materials
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Crystallography and molecular interactions
- Anatomy and Medical Technology
- Atomic and Subatomic Physics Research
- Electron and X-Ray Spectroscopy Techniques
- Fire dynamics and safety research
- Advancements in Photolithography Techniques
University of Surrey
2011-2023
University College London
2006-2010
Queen Mary University of London
2009-2010
Barts Health NHS Trust
2009
University of Trieste
1996-2005
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
1996-2005
University of Bologna
2005
Elettra-Sincrotrone Trieste S.C.p.A.
1997-2005
TU Dortmund University
2002
Abstract X-ray detectors are critical to healthcare diagnostics, cancer therapy and homeland security, with many potential uses limited by system cost and/or detector dimensions. Current sensitivities the bulk attenuation of materials consequently necessitate thick crystals (~1 mm–1 cm), resulting in rigid structures, high operational voltages cost. Here we present a disruptive, flexible, low cost, broadband, sensitivity direct transduction technology produced embedding atomic number bismuth...
The authors evaluated the effect on mammographic examinations of use synchrotron radiation to detect phase-perturbation effects, which are higher than absorption effects for soft tissue in energy range 15–25 keV. Detection was possible because high degree coherence sources. Synchrotron images were obtained a phantom and vitro breast specimens compared with conventional studies. On basis grades assigned by three reviewers, image quality former considerably higher, delivered dose fully compatible.
Phase contrast x-ray imaging is a powerful technique for the detection of low-contrast details in weakly absorbing objects. This method possible relevance field diagnostic radiology. In fact, within soft tissue does not give satisfactory results conventional absorption radiology, mammography being typical example. Nevertheless, up to now all applications phase technique, carried out on thin samples, have required radiation doses substantially higher than those delivered radiological...
Recently, new imaging modalities based on the detection of weak phase perturbations effects, among which are contrast and diffraction imaging, have been developed by several researchers. Due to their high sensitivity weakly absorbing details, these techniques seem be very promising for applications in medical field. On other hand, digital radiology is undergoing a wide diffusion, its benefits presently well understood. Up now, however, strong pixel size constraints associated with pattern...
We have developed a pixellated high energy X-ray detector instrument to be used in variety of imaging applications. The consists either Cadmium Zinc Telluride or (Cd(Zn)Te) bump-bonded large area ASIC and packaged with performance data acquisition system. 80 by pixels each 250 μm give better than 1 keV FWHM resolution at 59.5 1.5 141 keV, the same time providing speed performance. This system uses relatively simple wire-bonded interconnection scheme but this is being upgraded allow multiple...
Semiconducting polymer X-radiation detectors are a completely new family of low-cost radiation with potential application as beam monitors or dosimeters. These easy to process, mechanically flexible, relatively inexpensive, and able cover large areas. However, their x-ray photocurrents typically low as, being composed elements atomic number (Z), they attenuate x-rays weakly. Here, the addition high-Z nanoparticles is used increase attenuation without sacrificing attractive properties host...
The 250 μ m pitch 80x80 pixel HEXITEC detector systems have shown that spectroscopic imaging with an energy resolution of <1 keV FWHM per can be readily achieved in the range 5–200 Al-pixel CdTe biased to −500 V. This level has a variety applications but ability produce large area detectors remains barrier adoption this technology. limited size ASICs and defect free wafers dictates building monolithic is not presently viable option. A 3-side buttable module been developed cover areas arrays...
A theoretical analysis of the x‐ray phase contrast imaging and its validation via synchrotron radiation is here presented. Two different mathematical models have been followed: simpler ray‐optical approach more rigorous Fresnel‐Kirchoff diffraction theory. Subsequently, conditions upon which optical approximation can be used to describe image formation mechanism analyzed, taking into account also effects due finite source size detector resolution. It possible demonstrate that ray‐optics...
Preliminary studies have shown the effectiveness of multivariate analysis (MVA) for drug identification from energy-dispersive X-ray diffraction patterns. A statistical model to predict content profile a sample mixed composition was developed by applying MVA both experimental and simulated data. Separate data-sets were used building testing models. Both data predictions compared. Experimental included patterns small (5 mm diameter) samples with various cutting agents, acquired HPGe detector;...
A pixellated CdTe detector system comprising 2×2 modules has been developed for high energy spectroscopic X-ray imaging applications and an active area of 16 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The are made from the HEXITEC 80×80 ASIC 1 mm thick with Al-Schottky contacts. 250 μm pitch pixels outer guard ring on same pitch. single detectors have average resolution (FWHM) 800 eV at 59.9 keV. Limitations in multiple module...
A linear-array, silicon pixel detector, capable of counting single photons, was applied to mammography by using a synchrotron radiation beam. Images were obtained both mammographic phantom and breast-tissue sample. The image acquired with mean glandular dose 0.32 mGy. This detector combined beam allows acquisition high-contrast, low-dose images soft tissues.
A system for in vivo breast imaging with monochromatic x-rays has been designed and built at the synchrotron radiation facility Elettra Trieste (Italy) will be operational 2004. The design involves possibility of performing both planar mammography tomography. In present work, first results obtained a test set-up tomography are shown discussed. Tomographic images vitro breasts were acquired using x-ray beams energy range 20-28 keV linear array silicon pixel detector. Tomograms reconstructed...
A system for drug detection using X-ray diffraction is currently being developed by the DILAX collaboration. simulation program modelling response of an energy-dispersive has been developed, with two-fold aim selecting possible configurations prior to experimental tests and generating data statistical models prediction content. Simulated showed a good agreement results. The that main factor affecting shape pattern thickness sample. Scatter angle detector energy resolution have smaller effect...
This paper presents preliminary work aimed at assessing the feasibility of K-edge subtraction imaging using spectroscopic information provided by a pixellated energy-resolving Cadmium Zinc Telluride detector, having an active area 20×20 pixels 250 μm in size. Images test object containing different amounts Iodine-based contrast agent were formed above and below Iodine (33.2 keV) integrating, pixel pixel, windows spectrum. The results show that optimum integration window for details 1-2 mm...
Illicit drugs are imported into countries in myriad ways, including via the postal system and courier services. An automated is required to detect parcels for which X-ray diffraction a suitable technique as it non-destructive, material specific uses X-rays of sufficiently high energy penetrate containing range attenuating materials. A database has been constructed measured powder profiles several thousand materials likely be found parcels. These include drugs, cutting agents, packaging other...
Contrast-enhanced digital mammography (CEDM) is an alternative to conventional X-ray for imaging dense breasts. However, approaches CEDM require a double exposure of the patient, implying higher dose, and risk incorrect image registration due motion artifacts. A novel approach presented, based on hyperspectral imaging, where detector combining positional high-resolution spectral information (in this case Cadmium Telluride) used. This allows simultaneous acquisition two images required CEDM....
In order to ensure an early diagnosis of breast cancer, imaging system must fulfil extremely stringent requirements in terms dynamic range, contrast resolution and spatial resolution. Furthermore, reduce the dose delivered patient, a high efficiency detector device should be provided. this paper SYRMEP/FRONTRAD (SYnchrotron Radiation for MEdical Physics/FRONTier RADiology) mammography project, based on synchroton radiation novel solid state pixel detector, is briefly described. Particular...