A5024181605- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Digital Radiography and Breast Imaging
- Crystallography and Radiation Phenomena
- Advanced Electron Microscopy Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Nuclear Physics and Applications
- Laser-Plasma Interactions and Diagnostics
- Radiation Detection and Scintillator Technologies
- Digital Holography and Microscopy
- Advances in Oncology and Radiotherapy
- CCD and CMOS Imaging Sensors
- MRI in cancer diagnosis
- Osteoarthritis Treatment and Mechanisms
- Infrared Thermography in Medicine
- Nanoparticle-Based Drug Delivery
- Calibration and Measurement Techniques
- Advanced Semiconductor Detectors and Materials
- Veterinary Equine Medical Research
University of Trieste
2015-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2015-2024
Istituto Nazionale di Fisica Nucleare
2009-2022
Elettra-Sincrotrone Trieste S.C.p.A.
1999-2014
The Abdus Salam International Centre for Theoretical Physics (ICTP)
2006-2008
Center for Theoretical Physics
2006
Fondation pour la Recherche Médicale
2004
Robert Bosch Stiftung
2004
BioZyme (United States)
2004
Boston University
2004
Synchrotron-radiation computed tomography has been applied in many research fields. Here, PITRE (Phase-sensitive X-ray Image processing and Tomography REconstruction) PITRE_BM (PITRE Batch Manager) are presented. supports phase retrieval for propagation-based phase-contrast imaging/tomography (PPCI/PPCT), extracts apparent absorption, refractive scattering information of diffraction enhanced imaging (DEI), allows parallel-beam reconstruction conventional absorption CT data PPCT retrieved...
The authors evaluated the effect on mammographic examinations of use synchrotron radiation to detect phase-perturbation effects, which are higher than absorption effects for soft tissue in energy range 15–25 keV. Detection was possible because high degree coherence sources. Synchrotron images were obtained a phantom and vitro breast specimens compared with conventional studies. On basis grades assigned by three reviewers, image quality former considerably higher, delivered dose fully compatible.
Recently, new imaging modalities based on the detection of weak phase perturbations effects, among which are contrast and diffraction imaging, have been developed by several researchers. Due to their high sensitivity weakly absorbing details, these techniques seem be very promising for applications in medical field. On other hand, digital radiology is undergoing a wide diffusion, its benefits presently well understood. Up now, however, strong pixel size constraints associated with pattern...
To prospectively evaluate the diagnostic contribution of mammography with synchrotron radiation in patients questionable or suspicious breast abnormalities identified at combined digital (DM) and ultrasonography (US).The ethics committee approved this prospective study, written informed consent was obtained from all patients. Mammography performed a phase-detection technique laboratory. Forty-nine women who met least one inclusion criteria (palpable mass, focal asymmetry, architectural...
Diffraction enhanced imaging (DEI) is a phase-sensitive x-ray technique based on the use of an analyser crystal placed between sample and detector. In recent years, DEI has proven outstanding image quality both in material science medical imaging, as well capability to provide quantitative information. However, case objects featuring fine refractive structure, which not resolved by spatial resolution detector, fundamental requirements for applicability algorithm are fulfilled. Herein new...
At the SYnchrotron Radiation for MEdical Physics (SYRMEP) beamline of Elettra Synchrotron Light Laboratory in Trieste (Italy), an extensive research program bio‐medical imaging has been developed since 1997. The core carried out by SYRMEP collaboration concerns use (SR) clinical mammography with aim improving diagnostic performance conventional technique. first protocol patients, started 2006 completed at end 2009 and data analysis is now progress.
The aim of the SYRMA-CT collaboration is to set-up first clinical trial phase-contrast breast CT with synchrotron radiation (SR). In order combine high image quality and low delivered dose a number innovative elements are merged: CdTe single photon counting detector, state-of-the-art reconstruction phase retrieval algorithms. To facilitate an accurate exam optimization, Monte Carlo model was developed for calculation using GEANT4. this study, isotropic spatial resolution (120 μm)3 scans...
The purpose of this study was to explore the potential refraction contrast X-ray imaging biological tissues. Images dissected mouse lungs, heart, liver and legs were produced using medical beamline at Elettra Synchrotron Trieste, Italy. technique used diffraction enhanced imaging. This utilizes a silicon crystal positioned between tissue sample detector separate refracted X-rays from transmitted scattered radiation by Bragg diffraction. in images is related changes refractive index tissues,...
The measurement of the linear attenuation coefficients breast tissues is fundamental importance in field x-ray diagnostic imaging. Different groups have evaluated by carrying out direct measurements which specimens were thin and selected as homogeneous possible. Here, we use monochromatic high-intensity synchrotron radiation computed tomography (SR CT) to evaluate surgical energy range from 15 26.5 keV. X-ray detection performed a custom digital silicon micro-strip device, developed...
Breast computed tomography (BCT) is an emerging application of X-ray in radiological practice. A few clinical prototypes are under evaluation hospitals and new systems development aiming at improving spatial contrast resolution reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. Elettra, Italian synchrotron radiation facility, a program BCT based on...
Abstract Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates first combination computed tomography (CT) obtained by using edge-illumination technique a CdTe small-pixel (62 μ m) detector. A theoretical model is introduced, starting from standard attenuation-based decomposition leading to material decomposition. Each step followed quantification accuracy sensitivity on experimental data test phantom containing different...
As different methods to improve diffraction enhanced imaging are proposed, the authors introduce a simple algorithm that follows original idea of Chapman et al. [Phys. Med. Biol. 42, 2015 (1997)], but extend it general object featuring absorption, refraction, and ultrasmall-angle scattering. The information relative three effects is decoupled, requiring only images in input. Simulation experiment give accurate results, provided refraction scattering angles small compared rocking curve width....
Phase retrieval is a technique for extracting quantitative phase information from X-ray propagation-based phase-contrast tomography (PPCT).In this paper, the performance of different single distance algorithms will be investigated.The are herein called phase-attenuation duality Born Algorithm (PAD-BA), Rytov (PAD-RA), Modified Bronnikov (PAD-MBA), Paganin algorithm (PAD-PA) and Wu (PAD-WA), respectively.They all based on property weak absorption sample they employ only PPCT data.In...
X-ray phase contrast imaging (XPCi) methods are sensitive to in addition attenuation effects and, therefore, can achieve improved image for weakly attenuating materials, such as often encountered biomedical applications.Several XPCi exist, most of which have already been implemented computed tomographic (CT) modality, thus allowing volumetric imaging.The Edge Illumination (EI) method had, until now, not a CT modality.This article provides indications that quantitative 3D maps an object's and...
The first clinical study of phase-contrast mammography (PCM) with synchrotron radiation was carried out at the Synchrotron Radiation for Medical Physics beamline Elettra facility in Trieste (Italy) 2006-2009. involved 71 patients unresolved breast abnormalities after conventional digital and ultrasonography exams Radiology Department University Hospital. These cases were referred facility, images acquired using a propagation-based imaging technique. To investigate contribution effects to...
X-ray phase imaging has the potential to dramatically improve soft tissue contrast sensitivity, which is a crucial requirement in many diagnostic applications such as breast imaging. In this context, program devoted perform vivo phase-contrast synchrotron radiation computed tomography ongoing at Elettra facility (Trieste, Italy). The used technique propagation-based configuration, requires spatially coherent source and sufficient object-to-detector distance. work effect of distance on image...
Large-area CdTe single-photon-counting detectors are becoming more and attractive in view of low-dose imaging applications due to their high efficiency, low intrinsic noise absence a scintillating screen which affects spatial resolution. At present, however, since the dimensions single sensor small (typically few cm2), multi-module architectures needed obtain large field view. This requires coping with inter-module gaps close-to-edge pixels, generally show non-optimal behavior. Moreover,...
Abstract This paper presents a new flexible compact multi-modal imaging setup referred to as PEPI (Photon-counting Edge-illumination Phase-contrast imaging) Lab, which is based on the edge-illumination (EI) technique and chromatic detector. The system enables both X-ray phase-contrast (XPCI) spectral (XSI) of samples centimeter scale. work conceptually follows all stages in its realization, from design first results. can be operated four different modes, i.e. photon-counting/conventional,...
A simple algorithm that generalizes the diffraction enhanced imaging (DEI) technique is introduced and discussed by means of simulated experimental data. While original DEI Chapman et al (1997 Phys. Med. Biol. 42 2015) limited to objects featuring absorption refraction only, also ultra-small-angle scattering considered here. Utilizing only three images in input parametric are produced conveying information relative effects. The quality depends on choice images, as demonstrated a Monte Carlo...
Conventional contrast agents utilized in diagnostic radiology are based on x-ray absorption properties; alternative physical principles capable of providing a enhancement radiographs have never been applied. This study exploits the possibility using novel type media scattering. The consist microbubble echo-enhancing agents, usually applied ultrasound examinations, which invisible with conventional techniques. experiment was carried out at medical beamline synchrotron radiation laboratory...
Phase retrieval extracts quantitative phase information from x-ray propagation-based phase-contrast images. Notwithstanding inherent approximations, using a single sample-to-detector distance (SDD) is very attractive, because it imposes no setup complications or additional radiation dose compared to absorption-based imaging. Considering the phase-attenuation duality (ε=δ/β, where ε constant), simple absorption correction factor proposed for modified Bronnikov algorithm in computed tomography...