A5045242883- Protease and Inhibitor Mechanisms
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- RNA Interference and Gene Delivery
- Acute Myocardial Infarction Research
- Neonatal and Maternal Infections
- Hemodynamic Monitoring and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- Sepsis Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Retinal Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- DNA and Nucleic Acid Chemistry
- Lipid metabolism and disorders
- Effects of Vibration on Health
University of Trieste
2005-2022
Ospedale di Cattinara
2007-2013
Medica (Italy)
2006-2013
Ospedale Santa Maria
2007
Azienda Sanitaria Universitaria Integrata di Trieste
2006
University of Nebraska Medical Center
2006
Ospedale Santa Maria della Misericordia di Udine
2002
Ospedale Maggiore
1997-2002
In prostate adenocarcinoma, the dissection of expression behaviour eukaryotic elongation factors (eEF1A1/2) has not yet fully elucidated.The EEF1A1/A2 expressions were investigated by real-time PCR, western blotting (cytoplasmic and cytoskeletal/nuclear-enriched fractions) immunofluorescence in androgen-responsive LNCaP non-responsive DU-145 PC-3 cells, displaying a low, moderate high aggressive phenotype, respectively. Targeted experiments also conducted 22Rv1, cell line marking progression...
To derive and validate a predictive algorithm integrating nomogram-based prediction of the pretest probability infection with panel serum biomarkers, which could robustly differentiate sepsis/septic shock from noninfectious systemic inflammatory response syndrome.Multicenter prospective study.At emergency department admission in five University hospitals.Nine-hundred forty-seven adults inception cohort 185 validation cohort.None.A nomogram, including age, Sequential Organ Failure Assessment...
Aberrant coronary vascular smooth muscle cell (CSMC) proliferation is a pivotal event underlying intimal hyperplasia, phenomenon impairing the long-term efficacy of bypass surgery and angioplasty procedures. Consequently research has become focused on efforts to identify molecules that are able control CSMC proliferation. We investigated downregulation growth by small interfering RNAs (siRNAs) targeted against E2F1, cyclin E1, E2 genes, whose contribution only now being recognized....
The aims of this study were to compare a microsatellite polymorphism (PM) matrix metalloproteinase (MMP)-9 in patients with carotid atherosclerosis and control population, assess the relationship between PM plaque structure.One hundred fifty referring vascular diagnostic centers for suspected (at ultrasound examination: 110 positive, 40 negative) controls (n=110) have been genotyped MMP-9 PM. After controlling risk factors, allelic genotype frequencies significantly different among groups,...
Fibrinogen is an independent risk factor for cardiovascular disease and both D-Dimer Thrombin-Antithrombin complexes may be suitable as laboratory markers of deep venous thrombosis are becoming more widespread in clinical practice. The aim our study was to evaluate their normal range examine correlation with various factors. Fibrinogen, were assessed 516 subjects randomly selected from the National Health Service register Trieste (Italy). In community mean value fibrinogen 283 +/- 71 mg/dl....
The limited efficacy of current therapeutic approaches for a number socially relevant human diseases has required the exploration alternative and more effective strategies. In last three decades, nucleic acid based drugs (NABDs) have emerged as an attractive novel with great potential. NABDs which include antisense oligonucleotides, decoys, aptamers, triple helix forming DNAzymes, Ribozymes small interfering RNAs, been shown to be able efficiently counteract pathological gene expression in...
The prognostic value of quick sepsis-related organ failure assessment (qSOFA) outside intensive care units has been criticized. Therefore, we aimed to improve its ability in predicting 30-day all-cause mortality, and ruling out the cases at high risk death among patients with suspected or confirmed sepsis emergency department (ED) admission.This study is a secondary analysis prospective multicenter study. We built three predictive models combining qSOFA clinical variables serum biomarkers...
In a double-blind study, 296 patients with intermittent claudication (Fontaine stage II) were treated 250 mg ticlopidine twice daily, 500 aspirin every third day plus 75 dipyridamole three times or 300 xanthinol nicotinate daily for 6 months. Ticlopidine and aspirin/dipyridamole, but not nicotinate, improved platelet aggregation, reduced β-thromboglobulin, factor IV fibrinopeptide A concentrations, increased antithrombin III concentrations red blood cell filterability. No changes in lipid...