A5037503054- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Colorectal Cancer Surgical Treatments
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Body Contouring and Surgery
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Minimally Invasive Surgical Techniques
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- Stoma care and complications
- Regulation of Appetite and Obesity
- COVID-19 and healthcare impacts
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Diversity and Career in Medicine
Ospedale di Cattinara
2011-2025
University of Trieste
2016-2025
Fondazione Italiana Fegato
2019-2023
Collaborative Group (United States)
2023
Azienda Sanitaria Universitaria Integrata di Trieste
2017-2022
Policlinico S.Orsola-Malpighi
2016-2021
University of Bologna
2016-2018
IRCCS Materno Infantile Burlo Garofolo
2018
John Wiley & Sons (United States)
2016
University of Memphis
2016
Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT also source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndrome. However, our understanding mechanistic aspect obesity's impact on EV secretion from human remains limited.
Formalin-fixed tissues represent the most abundant clinical material for retrospective studies. However, formalin highly affects macromolecules, impairing their extraction and analysis. In this study, suitability of some potential substitutes RNA-based applications has been considered. Conventional was compared with methacarn commercial FineFIX. Their impact on overall RNA preservation investigated in a cell line-based model fixed during time course treatment series human tissues. yield...
Intestinal microbiota analysis of obese patients after bariatric surgery showed that Proteobacteria decreased laparoscopic sleeve gastrectomy (SG), while it increased gastric bypass (LGB). Comparing to normal weight (NW) patients, were selected for SG an almost equal amount Firmicutes and Bacteroidetes the ratio was not affected by surgery. Obese before LGB a predominance , whose regained relative abundance similar NW Bacteroides which in favour Prevotella bacterium associated with healthy...
A new arm of the renin-angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and (Ang)1-7, a heptapeptide acting through Mas receptor (MasR). Recent studies show that Ang1-7 an antiproliferative action on lung adenocarcinoma cells. The aim study was to characterize RAS expression in human colon investigate whether exerts effect cells.Gene, protein enzymatic activity main components were determined non-neoplastic mucosa as well tumor mass...
Abstract Objective: Gastric bypass (GBP) lowers food intake, body weight, and insulin resistance in severe obesity (SO). Ghrelin is a gastric orexigenic adipogenic hormone contributing to modulate energy balance action. Total plasma ghrelin (T‐Ghr) level low inversely related weight moderately obese patients, but these observations may not extend the acylated form (A‐Ghr) whose concentration increase moderate obesity. Design Methods: We investigated impact of GBP on T‐, A‐, A/T‐Ghr SO...
All European countries need to increase the number of health professionals in near future. Most efforts have not brought expected results so far. The current notion is that this mainly related fact female physicians will clearly outnumber their male colleagues within a few years nearly all countries. Still, women are underrepresented leadership and research positions throughout Europe.The MedGoFem project addresses multiple perspectives with participation stakeholders. goal facilitate...
An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading obesity and perhaps colon rectal cancer (CRC) in adults. In this study, we show that microbiota share a characteristic microbial profile with high colonization by mucin degraders species, such as Hafnia alvei Akkermansia muciniphila. addition, species Clostridium bolteae, bacterium associated insulin resistance, dyslipidemia, inflammation, has been presence of oncogenic Human...
Abstract Background Homozygous familial hypercholesterolemia (HoFH) is a rare life-threatening condition that represents therapeutic challenge. The vast majority of HoFH patients fail to achieve LDL-C targets when treated with the standard protocol, which associates maximally tolerated dose lipid-lowering medications lipoprotein apheresis (LA). Lomitapide an emerging therapy in HoFH, but its place treatment algorithm disputed because comparison long-term efficacy versus LA reducing burden...
Abstract Background Obesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). Recent research has highlighted the crucial role of tissue—liver axis in development MASLD. In this study, we investigated potential omentin-1, a novel adipokine expressed VAT, obesity-related MASLD pathogenesis. Methods Through silico analysis differentially genes VAT from obese patients...
Abstract Background This study aims (I) to evaluate whether the Multidimensional Prognostic Index (MPI) score is associated with postoperative outcomes and (II) develop a prognostic model for individual complication‐risk prediction following colorectal cancer (CRC) surgery. Method prospective multicentric cohort study. Consecutive ≥75‐year‐old candidates elective CRC surgery were enrolled from October 2017 August 2019. Patients underwent standardized preoperative geriatric assessment...
Obesity is a primary limiting factor in liver stiffness measurement (LSM). The impact of obesity has always been evaluated terms body mass index (BMI), without studying the effects skin-to-liver distance (SLD) on LSM. We studied SLD LSM cohort obese patients undergoing bariatric surgery and intra-operatory biopsy.
On January 30, 2020, the World Health Organization declared COVID-19 as a "public health emergency of international concern." The primary aim study was to evaluate weight and food habit changes during outbreak. secondary endpoint explore psychological factors, arising pandemic, influencing dietary variations.