A5071646464- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Methemoglobinemia and Tumor Lysis Syndrome
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism and Genetic Disorders
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic function and diabetes
- Liver Diseases and Immunity
- Circular RNAs in diseases
- Folate and B Vitamins Research
- Clinical Nutrition and Gastroenterology
- Hemoglobin structure and function
Fondazione Italiana Fegato
2016-2025
International Flame Research Foundation
2013-2025
AREA Science Park
2009-2022
National Research and Innovation Agency
2022
Eijkman Institute for Molecular Biology
2022
Engineering (Italy)
2022
University of Trieste
2011-2021
University of Turin
2008-2017
Azienda Ospedaliera Santa Maria Degli Angeli
2017
Centro di Riferimento Oncologico
2017
Fatty liver (FL) is the most frequent disease in Western countries. We used data from Dionysos Nutrition & Liver Study to develop a simple algorithm for prediction of FL general population.216 subjects with and 280 without suspected were studied. was diagnosed by ultrasonography alcohol intake assessed using 7-day diary. Bootstrapped stepwise logistic regression identify potential predictors among 13 variables interest [gender, age, ethanol intake, alanine transaminase, aspartate...
Background: Although hepatic steatosis is seen with increasing frequency in clinical practice, its prevalence and risk factors are unknown. Objective: To investigate the of for steatosis, such as alcohol consumption obesity. Design: Cross-sectional, observational study. Setting: Participants Dionysos Study. Patients: 257 participants assigned to one four categories (67 controls, 66 obese persons, 69 heavy drinkers, 55 drinkers). Measurements: Ethanol intake, assessed by a validated...
Abstract The prevalence of and the risk factors for fatty liver have not undergone a formal evaluation in representative sample general population. We therefore performed cross-sectional study town Campogalliano (Modena, Italy), within context Dionysos Project. Of 5,780 eligible persons aged 18 to 75 years, 3,345 (58%) agreed participate study. Subjects with suspected disease (SLD), defined on basis elevated serum alanine aminotransferase (ALT) γ-glutamyl-transferase (GGT) activity,...
Background —The Dionysos Study is a cohort study of the prevalence chronic liver disease in general population two northern Italian communities. It included 6917 subjects, aged 12–65 (69% total population). Aims aim this part was to examine relationship daily alcohol intake, type alcoholic beverage consumed, and drinking patterns presence induced damage an open population. Patients methods —6534 free virus related participating first cross-sectional study, were fully examined. Each subject...
Nonalcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of metabolic syndrome and may evolve into hepatocellular carcinoma (HCC). Only scanty clinical information is available on HCC in NAFLD. The aim this multicenter observational prospective study was to assess features patients with NAFLD-related (NAFLD-HCC) compare them those hepatitis C virus (HCV)-related HCC. A total 756 either NAFLD (145) or HCV-related chronic (611) were enrolled secondary care Italian centers....
Data on the prevalence of chronic liver disease, derived from selected series hospitalized patients or mortality registers, underestimate disease. The Dionysos Study is a cohort study that investigated for first time disease in general population. All citizens two towns northern Italy, Campogalliano and Cormons, aged 12 to 65 yr were contacted by letter. From March 1991 through 1993, 6,917 total 10,150 enrolled (compliance, 69%). standardized protocol each enrollee included (a)...
Abstract To demonstrate that the lipid volume fraction In liver steatosis can be accurately estimated with in vivo hydrogen‐1 magnetic resonance (MR) spectroscopy, authors developed a calibration procedure based on vitro MR spectroscopy of extracts from steatotlc specimens. The fractions determined were compared results histomorphometry and calibrated computed tomographic (CT) data. fat was good agreement CT results, whereas underestimated amount hepatic fat. indicate determination steatotic...
BACKGROUND The severity, clinical course, and risk of hepatitis C virus (HCV) related chronic liver disease are still rather poorly defined. AIMS To investigate the prevalence, factors, severity HCV in general population, whether infection with a specific genotype is associated an increased cirrhosis or hepatocellular carcinoma. METHODS RNA determination by polymerase chain reaction (PCR) genotyping were performed all anti-HCV positive subjects belonging to Dionysos study (6917 subjects)....
Liver steatosis is often found in association with common cardiometabolic disorders, conditions that may all occur a shared context of abdominal obesity and dyslipidemia. An algorithm for identifying liver the fatty index (FLI). The lipid accumulation product (LAP) an formulated representative sample US population to identify disorders. Because FLI LAP share two components, namely waist circumference fasting triglycerides, we evaluated ability same study from Northern Italian town where was...
RATIONALE AND OBJECTIVES. The authors evaluated the degree of fatty infiltration liver in subjects with diffuse steatosis using image-guided 1H localized MR spectroscopy and correlated magnetic resonance (MR)-determined fat fraction computed tomography (CT) liver/spleen density ratio histologic evaluation. METHODS. measurements were performed at 1.5 T by applying a double-spin-echo localization sequence. Twenty-six patients underwent CT examinations ultrasound (US)-guided biopsy....
Using the general population of Dionysos Study, we followed up 144 subjects without fatty liver (FL−) and 336 with (FL+) for a median time 8.5 years. All had suspected disease (SLD) defined as altered enzymes, high mean corpuscular volume, or low platelet count in absence HBV HCV infection. Ethanol intake was assessed using food frequency questionnaire, FL diagnosed ultrasonography. The incidence remission rates were 18.5 55.0 per 1,000 person-years. Progression to cirrhosis HCC rare both...