Maria Consiglia Bragazzi
A5054751682- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Genetic factors in colorectal cancer
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Eosinophilic Esophagitis
- RNA Research and Splicing
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
Sapienza University of Rome
2014-2024
Ospedale Santa Maria Goretti
2020
Policlinico Umberto I
2018
Medico
2012
Ospedale Regina Margherita
2010-2011
University of L'Aquila
2007
Texas A&M University System
2007
Marche Polytechnic University
2007
University of Milan
2007
Ospedale San Paolo
2007
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe integrated analysis somatic mutations, RNA expression, copy number, DNA methylation by The Cancer Genome Atlas a set predominantly intrahepatic CCA cases propose molecular classification scheme. We identified IDH mutant-enriched subtype distinct features including low expression chromatin modifiers, elevated mitochondrial genes, increased number....
Cholangiocarcinoma (CCA) is a malignant tumour, arising from biliary epithelium at any portion of the tree, characterized by bad prognosis and poor response to current therapies. CCA currently classified as intrahepatic (IH-CCA) or extrahepatic (EH-CCA). The distinction between IH-CCA EH-CCA has become increasingly important, epidemiological features (i.e., incidence risk factors), biologic pathologic characteristics clinical course are largely different. New insights into hepatic tree stem...
Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little known about the genetic contribution severity and progression PSC. The aim this study identify variants associated with PSC development complications. Design We collected standardised subphenotypes in large cohort 3402 patients After quality control, we combined 130 422 single nucleotide polymorphisms all...
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA enriched in stem cells, which correlate aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, markedly down-regulated human CCA. Our aim was evaluate, primary cultures intrahepatic (iCCA), effects FXR agonist obeticholic acid (OCA), semisynthetic bile derivative, on their cancerogenic potential. Primary iCCA cell were prepared from surgical specimens mucinous or...
In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, mucosal protective agents are widely used, alone as add-on treatment, to increase response proton-pump inhibitors, which not indicated in infancy pregnancy account for significant cost expenditure.
Background: Cholangiocarcinoma cells express and secrete insulin-like growth factor I (IGF-I) vascular endothelial (VEGF). Objective: To measure IGF-I VEGF in bile serum of patients with extrahepatic cholangiocarcinoma to evaluate their performance as diagnostic markers. Design: Cross-sectional study. Setting: Inpatients at the Division Gastroenterology, University Hospital, Ancona, Italy. Patients: 73 who consecutively had endoscopic retrograde cholangiopancreatography (ERCP), including (n...
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures mucin- mixed-IHCCA were prepared from surgical specimens (N. 18 IHCCA patients) evaluated for cell proliferation (MTS assay) apoptosis (Caspase 3) after incubation (72 hours) with increasing concentrations different drugs. In vivo, subcutaneous human tumor xenografts evaluated. characterized by a pattern expression cancer stem markers, drug...
Cholangiocarcinoma (CCA) is a very aggressive cancer showing the presence of high stem cells (CSCs). Doublecortin-like kinase1 (DCLK1) has been demonstrated as CSC marker in different gastroenterological solid tumors. Our aim was to evaluate vitro expression and biological function DCLK1 intrahepatic CCA (iCCA) perihilar (pCCA).Specimens surgically resected human were enzymatically digested, submitted immunosorting for specific markers (LGR5 [leucine-rich repeat-containing G protein-coupled...
Cholangiocarcinoma (CCA) and its subtypes (mucin- mixed-CCA) arise from the neoplastic transformation of cholangiocytes, epithelial cells lining biliary tree. CCA has a high mortality rate owing to aggressiveness, late diagnosis resistance radiotherapy chemotherapeutics. We have demonstrated that is enriched for cancer stem which express mesenchymal transition (EMT) traits, with these features being associated aggressiveness drug resistance. TGF-β signaling upregulated in involved EMT....