A5075261540- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Ion Transport and Channel Regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gut microbiota and health
- IgG4-Related and Inflammatory Diseases
- Pancreatitis Pathology and Treatment
- Nitric Oxide and Endothelin Effects
- Systemic Sclerosis and Related Diseases
- Dysphagia Assessment and Management
- Hepatitis B Virus Studies
Medizinische Hochschule Hannover
2016-2025
Klinikum Braunschweig
2024-2025
ERN RARE-LIVER
2023-2024
ERN GUARD-Heart
2023
University of Duisburg-Essen
2018-2022
Essen University Hospital
2018-2020
GTx (United States)
2016
Endocrinology Research Center
2016
Hochschule Hannover
2013
Academic Medical Center
2013
Abstract —Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor. It formed by protein arginine N -methyltransferases (PRMTs), which utilize S -adenosylmethionine as methyl group donor. ADMA plasma concentration elevated in hypercholesterolemia, leading to endothelial dysfunction and producing proatherogenic changes of cell function. Four different isoforms human PRMTs have been identified. Because the release from cells increased presence native or oxidized...
Oxidative stress is involved in the pathophysiology of atherosclerosis, diabetes mellitus, hypertension, obesity, and cigarette smoking, all these being risk factors for coronary heart disease (CHD). We tested hypothesis that CHD are associated with abundant systemic oxidative stress.We conducted a case-control study 93 patients control subjects frequency-matched by age sex. Urinary excretion F2-isoprostane 8-iso-prostaglandin (PG) F2alpha its major urinary metabolite,...
We determined the frequencies of genetic apolipoprotein E isoforms in 570 survivors myocardial infarction, all with demonstrable coronary heart disease, as compared 624 healthy persons. In controls, E-4/E-3 heterozygosity was associated total cholesterol concentrations 1985 (SD 364) mg/L and low-density lipoprotein (LDL)-cholesterol 1306 332) mg/L. Significantly lower values, 1811 312) 1121 274) mg/L, respectively, were observed for E-3/E-2 heterozygous respective values significantly higher...
Liver transplantation (LT) is the only definitive treatment for patients with end-stage liver disease due to primary sclerosing cholangitis (PSC), but a high rate of biliary strictures (BSs) and recurrent (recPSC) has been reported. In this multicenter study, we analyzed large patient cohort long follow-up in order evaluate incidence BS recPSC, assess impact on survival after LT, identify risk factors. We collected clinical, surgical, laboratory data records inflammatory bowel (IBD),...
Abstract Background & Aims The importance of the intestinal microbiota for onset and clinical course many diseases, including liver diseases like non‐alcoholic steatohepatitis cirrhosis, is increasingly recognized. However, role in chronic hepatitis C virus ( HCV ) infection remains unclear. Methods In a cross‐sectional approach, 95 patients chronically infected with (n=57 without cirrhosis [ NO ‐ CIR ]; n=38 ]) 50 healthy controls HC documented was analysed. Results Alpha diversity,...
<b>Purpose:</b> Hepatic vein pressure gradient (HVPG) is the gold standard for diagnosing clinically significant portal hypertension (CSPH). The aim of this study was to investigate—in comparison HVPG—the ability diagnose CSPH by liver and spleen stiffness measurements obtained acoustic radiation force impulse (ARFI) imaging. <b>Materials Methods:</b> A total 78 patients (mean age: 53 ± 13 years, 62 % male) with chronic disease were enrolled in study. Each patient received (LSM) (SSM) ARFI,...
Abstract At a time of growing governmental restrictions and ‘physical distancing’ in order to decelerate the spread COVID-19, psychological challenges are increasing. Social media plays an important role maintaining social contact as well exerting political influence. World leaders use it not only keep citizens informed but also boost morale manage people’s fears. However, some do follow this approach; example is German Chancellor. In large online survey, we aimed determine levels COVID-19...
Abstract Background & Aims Evidence for the benefit of scheduled imaging early detection hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow‐up strategies PSC with hypothesis that regular improves survival. Methods collected retrospective data from 2975 patients 27 centres. Patients were followed start or case clinical 1 January 2000, until death last alive. The endpoint was all‐cause mortality. Results A broad variety...
Background and AimsNon-invasive tests (NIT) for clinically significant portal hypertension (CSPH) in compensated advanced chronic liver disease (cACLD) lack validation patients infected with hepatitis D virus (HDV).MethodsHDV-cACLD (LSM ≥10 kPa or histological METAVIR F3/F4 fibrosis) who underwent paired HVPG NIT assessment at Medical University of Vienna Hannover School between 2013 2023 were retrospectively included.Liver stiffness measurement (LSM), von Willebrand factor to platelet count...
Slc26a9 is an anion transporter that strongly expressed in the stomach and lung. variants were recently found associated with a higher incidence of meconium ileus cystic fibrosis (CF) infants, raising question whether intestine what its functional role is. messenger RNA (mRNA) was highly mucosae murine human upper gastrointestinal tract, abrupt decrease expression levels beyond duodenum. Absence SLC26a9 increased intestinally related mortality transmembrane conductance regulator...
Objective. Percutaneous endoscopic gastrostomy (PEG) is often used for the feeding of patients with malnutrition due to dysphagia, and despite more than 30 years experience, numerous questions on its benefit remain. This was a prospective observational study assess safety PEG. Material methods. One hundred nineteen mean age 63 (21–91 years) who were admitted Hannover Medical School between November 2010 March 2012 had an indication PEG according German guidelines included. Primary endpoints...
Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little known about the genetic contribution severity and progression PSC. The aim this study identify variants associated with PSC development complications. Design We collected standardised subphenotypes in large cohort 3402 patients After quality control, we combined 130 422 single nucleotide polymorphisms all...
Abstract Background Orthotopic liver transplantation (OLT) in patients with inflammatory bowel disease (IBD) represents a special patient population high heterogeneity. The management of IBD transplant recipients is challenging due to the need balance immunosuppressive therapy, flares and graft survival. Therefore, detailed analysis clinical parameters essential better understand outcomes optimize strategies this unique cohort. Methods This monocentric, retrospective included concomitant OLT...
Abstract Background Inflammatory bowel disease (IBD) affects gastrointestinal function and may alter faecal odour due to changes in the gut microbiome metabolism. Given relationship between diet, health diversity, exploring link dietary habits IBD seems crucial. This study investigates associations behaviour, flatulence perception activity patients compared healthy controls (HC). Methods From October 2023 2024, a total of 238 (women: 51.3%; CD: 59.7%; remission: 33.5%) 97 HC (women:70.1%)...
Cholestatic complications remain a primary cause of post-liver transplantation (LTX) morbidity in pediatric patients. Standard biliary access by endoscopic retrograde cholangioscopy may not be feasible due to modified drainage. Percutaneous transhepatic drainage (PTCD) performed alternatively. However, systematic data concerning safety and efficacy PTCD these patients are scarce. In this retrospective study, procedural characteristics following LTX were analyzed. We compared laboratory...
Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s (CD), consists of chronic gastrointestinal inflammation, with nutrition playing a significant role in its development. IBD patients often face dietary challenges affecting their quality life (QoL), yet research on food-related QoL (FR-QoL) sex-specific differences is limited. It was hypothesized that patterns choices impact these effects vary by sex. The objective this analysis was, therefore, to...
Abstract The psychosocial effects of eating and drinking – summarized as food-related quality life (FR-QoL) are underexplored in inflammatory bowel disease (IBD). Currently, there is no German instrument to assess FR-QoL IBD patients. This study aimed translate the validated English FR-QoL-29 questionnaire into evaluate its validity reliability. A monocentric, cross-sectional was conducted at a tertiary referral center with patients healthy controls. Participants completed questionnaires on...
Obesity and overweight are global health problems.To evaluate the diagnostic accuracy of liver stiffness measurement (LSM) using acoustic radiation force impulse (ARFI) elastography in obese patients for staging fibrosis.Ninety-seven (mean age: 50 years, 50% male) with body mass index (BMI) ≥25 kg/m(2) BMI: 31 ) were prospectively enrolled. All underwent ARFI biopsy. In 87/97 patients, transient (TE) was performed (M- XL-probes). Patients divided into two groups respectively: overweight: BMI...
Background Impaired salt and water absorption is an important feature in the pathogenesis of diarrhea inflammatory bowel disease (IBD). We analyzed expression proinflammatory cytokines infiltrating immune cells function Na+/H+ exchanger isoform 3 (NHE3) its regulatory PDZ-adaptor proteins NHERF1, NHERF2, PDZK1 colon interleukin-10–deficient (IL-10−/−) mice. Methodology/Principal Findings Gene protein were by real-time reverse transcription polymerase chain reaction (qRT-PCR), situ RT-PCR,...
The aim of this study was to investigate the Alfapump, an automated low-flow pump system for treatment refractory ascites (RA) as alternative repeated large-volume paracentesis in patients with contraindication placement a transjugular intrahepatic portosystemic shunt (TIPS) or liver transplantation.In 21 consecutive RA and TIPS, Alfapump implanted at Hannover Medical School between December 2012 May 2016. Repeated laboratory, clinical, microbiology data were collected analyzed assess...