A5062171966- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Congenital Anomalies and Fetal Surgery
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Renal and Vascular Pathologies
- Polyomavirus and related diseases
- Hepatitis B Virus Studies
Medizinische Hochschule Hannover
2011-2025
Due to the shortage of deceased donors ABO-incompatible (ABOi) living kidney transplantation has become a popular alternative transplantation. In recent years, recipient desensitization with combination anti-CD20 treatment (rituximab), antigen-specific immunoadsorptions (IA) and intravenous immunoglobulin (IVIG), led promising short-term intermediate-term results. However, little is known about impact this intensified protocol on risk surgical infectious complications.We retrospectively...
The feasibility of de novo everolimus without calcineurin inhibitor (CNI) therapy following liver transplantation was assessed in a multicenter, prospective, open-label trial. Liver transplant patients were randomized at 4 weeks to start and discontinue CNI, or continue their current CNI-based regimen. primary endpoint adjusted estimated GFR (eGFR; Cockcroft-Gault) month 11 postrandomization. A 24-month extension phase followed 81/114 (71.1%) eligible 35 mean eGFR benefit from randomization...
Cholestatic complications remain a primary cause of post-liver transplantation (LTX) morbidity in pediatric patients. Standard biliary access by endoscopic retrograde cholangioscopy may not be feasible due to modified drainage. Percutaneous transhepatic drainage (PTCD) performed alternatively. However, systematic data concerning safety and efficacy PTCD these patients are scarce. In this retrospective study, procedural characteristics following LTX were analyzed. We compared laboratory...
Abstract Objectives The European Liver Transplant Registry (ELTR) has been collecting data on liver transplantation (LT) in Europe since 1968. aim of this report is to outline the number, techniques utilized, indications for, and outcomes pediatric LT (pLT) Europe, focusing Year 2022 comparison preceding 5 years. Methods Data were obtained from ELTR Eurotransplant (ET). Summary statistics performed. Results In 2022, 585 pLTs performed Europe. annual number pLT decreased for third consecutive...
Low portal vein flow after orthotopic liver transplantation due to spontaneous splenorenal shunt is associated with hepatic hypoperfusion and poor allograft survival. We describe a case of recovered by ligation the left renal on first postoperative day 54-year-old female alcoholic cirrhosis, chronic kidney failure shunt. After reperfusion flows were extremely low, but because severe coagulopathy diffuse bleeding, was not attempted. A relaparotomy performed ligated at its confluence inferior...
Introduction: Belatacept was approved in 2011 as novel immunosuppressive agent for prevention of acute rejection adult patients undergoing kidney transplantation on the basis two open-label, randomized, multicenter, controlled phase 3 studies. From these studies meanwhile years' data are published but longer term results particular interest. Patients and methods: March 2001 November 2002 a total 218 were enrolled an 2 study. randomly assigned to treatment groups: “less intensive” belatacept,...
Introduction: Combined lung and liver transplantation (Lu-LTx) is a rare procedure established as the ultimate therapeutic option for patients with end stage respiratory insufficiency severe impairment of hepatic function that may jeopardize outcome isolated (LuTx), or render this impossible. In our clinic regularly performed since 1999. Accordingly we are able to present first long term experience complex procedure. Patients methods: Between April 1999 August 2011 twenty-two underwent...
Background: Combined lung and liver transplantation is an established therapy for selected patients with cystic fibrosis. The initial sequence has primarily been first, mainly because it believed that the more sensitive to prolonged ischemia than liver. However, this drawbacks, including frequent occurrence of primary graft dysfunction (PGD) lung, essentially due coagulopathy, blood loss, transfusion hemodynamic instability during transplantation. Consequently, we changed "liver first" in...