Xavier Verhelst
A5008360462- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Hepatitis Viruses Studies and Epidemiology
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Eosinophilic Esophagitis
- Adipose Tissue and Metabolism
Ghent University Hospital
2016-2025
Ghent University
2013-2024
Centre de Recherche sur l'Inflammation
2024
Inserm
2024
ERN GUARD-Heart
2020-2023
Universität Hamburg
2023
University Medical Center Hamburg-Eppendorf
2023
KU Leuven
2022
Universitair Ziekenhuis Brussel
2021
ERN RARE-LIVER
2020
Background Transarterial chemoembolization (TACE) is the recommended treatment for intermediate hepatocellular carcinoma (HCC) according to Barcelona Clinic Liver Cancer guidelines. Prospective uncontrolled studies suggest that yttrium 90 (90Y) transarterial radioembolization (TARE) a safe and effective alternative. Purpose To compare efficacy safety of TARE with TACE unresectable HCC. Materials Methods In this single-center prospective randomized controlled trial (TRACE), 90Y glass was...
Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and promotes inflammation, fibrosis, progression hepatocellular carcinoma (HCC). Angiopoietin‐2 (Ang‐2) is a key regulator angiogenesis. We aimed investigate role Ang‐2 its potential as therapeutic target in NASH using human samples, vivo mouse models, vitro assays. Serum levels were determined 104 obese patients undergoing bariatric surgery concomitant liver biopsy. The effect Ang‐2/Tie2 receptor inhibiting...
INTRODUCTION: In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization surrogate markers because their association with survival has been defined. METHODS: The patient cohort from the GLOBAL PBC Study Group was used, comprising long-term follow-up data European North American centers. Ursodeoxycholic acid-treated untreated patients levels ≤1 × upper limit...
Summary Background Fibrosis stage predicts prognosis in patients with chronic liver disease independent of aetiology, although its precise role risk stratification primary biliary cholangitis (PBC) remains undefined. Aim To assess the utility baseline fibrosis predicting long‐term outcomes context biochemical Methods In a large and globally representative cohort PBC, biopsies performed from 1980 to 2014 were evaluated. The predictive ability histologic addition treatment response at 1 year...
Background & AimsThe Primary Biliary Cholangitis (PBC) Obeticholic Acid (OCA) International Study of Efficacy (POISE) randomized, double-blind, placebo-controlled trial demonstrated that OCA reduced biomarkers associated with adverse clinical outcomes (ie, alkaline phosphatase, bilirubin, aspartate aminotransferase, and alanine aminotransferase) in patients PBC. The objective this study was to evaluate time first occurrence liver transplantation or death the POISE open-label extension vs...
Background and Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC strongly associated with colitis a disruption of the gut-liver axis, macrophages involved in pathogenesis PSC. However, how interactions specific macrophage populations contribute to incompletely understood. Approach Results: We investigated impact cholestasis on hepatic colonic microenvironment, performed...
In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion patients. The aim study was describe the incidence cirrhosis-associated complications patients with PBC and assess risk factors impact on survival.Cohorts UDCA-treated from 16 European North-American liver centers were included. We used Cox proportional hazards assumptions Kaplan-Meier estimates.During 8.1 years' median...
Changes over time in the presenting features and clinical course of patients with primary biliary cholangitis are poorly described. We sought to describe temporal trends patient disease characteristics a 44‐year period across large international cohort 4,805 diagnosed between 1970 2014, from 17 centers Europe North America. Patients were divided into five cohorts according their year diagnosis: 1970‐1979 (n = 143), 1980‐1989 858), 1990‐1999 1,754), 2000‐2009 1,815), ≥2010 235). Age at...
Abstract Background & Aims Evidence for the benefit of scheduled imaging early detection hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow‐up strategies PSC with hypothesis that regular improves survival. Methods collected retrospective data from 2975 patients 27 centres. Patients were followed start or case clinical 1 January 2000, until death last alive. The endpoint was all‐cause mortality. Results A broad variety...
BACKGROUND Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive liver disease, causing episodic with intense pruritus. This case report highlights the effectiveness of early plasmapheresis as therapeutic option for BRIC type 2, offering rapid symptom relief and termination cholestatic episodes. It contributes to limited evidence supporting treatment flares resistant conventional therapies. CASE SUMMARY A 43-year-old male 2 presented fatigue, jaundice, severe...
Abstract Background Functional disturbances of the endoplasmic reticulum (ER) lead to activation unfolded protein response (UPR), which is involved in consecutive steps carcinogenesis. In human hepatocellular carcinoma (HCC), UPR shown be activated; however, little known about kinetics and effects modulation HCC. Methods We sequentially monitored over time an orthotopic mouse model for HCC explored on cell viability proliferation vitro model. Results The expression ER-resident chaperones...