Javier Crespo
A5028677580- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Pancreatitis Pathology and Treatment
- Alcohol Consumption and Health Effects
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal disorders and treatments
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Diabetes and associated disorders
- Pediatric Hepatobiliary Diseases and Treatments
Instituto de Investigación Marqués de Valdecilla
2016-2025
Marqués de Valdecilla University Hospital
2016-2025
Universidad de Cantabria
2016-2025
Sociedad Española de Patología Digestiva
2019-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017-2024
Instituto de Salud Carlos III
2018-2024
CIC bioGUNE
2017-2024
Weatherford College
2019-2023
Navarre Institute of Health Research
2023
University of Massachusetts Chan Medical School
2023
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical functional analyses identified muramyl dipeptide (MurNAc-L-Ala-D-isoGln) derived from peptidoglycan as essential structure in bacteria by NOD2. Replacement L-Ala for D-Ala or D-isoGln L-isoGln eliminated ability stimulate indicating stereoselective recognition. Muramyl was NOD2...
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis hepatocellular carcinoma globally. This burden is expected to increase as epidemics obesity, diabetes metabolic syndrome continue grow. The goal this analysis was use Markov model forecast NAFLD using currently available data.A used estimate NASH progression in eight countries based on data for adult prevalence obesity type 2 mellitus (DM). Published estimates expert...
Background & AimsElafibranor is an agonist of the peroxisome proliferator−activated receptor-α and receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, lipid metabolism reduces inflammation. We assessed safety efficacy elafibranor in international, randomized, double-blind placebo-controlled trial patients with nonalcoholic steatohepatitis (NASH).MethodsPatients NASH without cirrhosis were randomly assigned to groups given 80 mg (n = 93), 120 91), or placebo 92) each...
The main objective of this study was to analyze the pathogenic role tumor necrosis factor alpha (TNF-alpha) system in development nonalcoholic steatohepatitis (NASH). Fifty-two obese patients were studied. We investigated: (1) expression mRNA TNF-alpha and their p55 p75-receptors by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) hepatic adipose tissues; (2) relationship between TNF-alpha, p55, p75 severity NASH. Obese without NASH control group. A remarkable increase...
The role of vitamin D status in COVID-19 patients is a matter debate.To assess serum 25-hydroxyvitamin (25OHD) levels hospitalized with and to analyze the possible influence on disease severity.Retrospective case-control study 216 197 population-based controls. Serum 25OHD were measured both groups. association severity (admission intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated.Of patients, 19 supplements analyzed separately. In mean ± standard...
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis 843 patients with DILI enrolled into the Spanish Registry over 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug outcome data collected.A total patients, mean age 54 years (48% females), up 2018. Hepatocellular was associated younger (adjusted odds ratio [aOR] per year 0.983; 95%...
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite growing number studies linking with altered serum metabolite levels, an obstacle development metabolome-based NAFLD predictors has been lack large cohort data biopsy-proven patients matched for key metabolic features such as obesity. We studied 467 biopsied individuals normal histology (n = 90) or diagnosed (steatosis,...
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic worldwide and includes a broad spectrum histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic (NAFL) to steatohepatitis (NASH). While biopsy reference gold standard for NAFLD diagnosis staging, it has limitations due its sampling variability, invasive nature, high cost. Thus, there need noninvasive biomarkers that are robust, reliable, cost effective. In this study, we measured 540 lipids amino...
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a unmet need. Here, we identify MCJ (Methylation-Controlled J protein) as target for non-alcoholic steatohepatitis (NASH), advanced phase of NAFLD. endogenous negative regulator respiratory chain Complex I that acts to restrain mitochondrial respiration. We show therapeutic targeting in nanoparticle-...
Direct-acting antiviral agents (DAAs) are highly effective and well tolerated in patients with chronic hepatitis C virus infection, including those compensated cirrhosis. However, fewer data available more advanced liver disease. Our retrospective, noninterventional, national, multicenter study from the Spanish Hepa-C registry investigated effectiveness safety of interferon-free DAA regimens disease, decompensated cirrhosis, routine practice (all currently approved were registered). Patients...
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury it second most common cause failure. Mitochondrial dysfunction contributes APAP-induced but mechanism by which APAP causes hepatocyte toxicity not completely understood. Therefore, we lack efficient therapeutic strategies this pathology. Here show that interferes with formation mitochondrial respiratory supercomplexes via negative regulator MCJ, leads...