Manuel Romero
A5003971524- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Lipid metabolism and disorders
- Cardiac Imaging and Diagnostics
- Hepatitis C virus research
- Liver Disease and Transplantation
- Coronary Interventions and Diagnostics
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Drug-Induced Hepatotoxicity and Protection
- Biosimilars and Bioanalytical Methods
- Hemoglobinopathies and Related Disorders
- Skin Diseases and Diabetes
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Blood transfusion and management
- Vasculitis and related conditions
- Gastrointestinal disorders and treatments
- Pharmaceutical Economics and Policy
- Liver Diseases and Immunity
Hospital Universitario Infanta Leonor
2013-2024
Hospital Juan Ramón Jiménez
2023
Hospital Clínico Universitario Virgen de la Victoria
2004-2019
Hospital Universitario de Valme
1997-2017
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017
Hospital Comarcal de Inca
2016
Hospital Universitario Virgen del Rocío
2012
Centro de Investigación Biomédica en Red
2008
Instituto de Salud Carlos III
2008
Diagnosis in the early stages of hereditary transthyretin (ATTR) amyloidosis is imperative to support timely treatment prevent or delay disease progression. Genetic testing setting genetic counselling enables identification carriers a TTR gene mutation who are therefore at risk developing TTR-associated disease. Knowledge different genotypes and how they manifest symptomatic should facilitate development structured targeted approach enable diagnosis ATTR on first manifestation earliest...
The effect of alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, on coronary plaque burden in patients with familial hypercholesterolemia has not been addressed. Our aim was to assess changes and its characteristics after treatment alirocumab by quantification characterization atherosclerotic throughout the tree basis noninvasive analysis computed tomographic angiography asymptomatic subjects receiving optimized stable maximum tolerated statin dose or without...
Direct-acting antiviral agents (DAAs) are highly effective and well tolerated in patients with chronic hepatitis C virus infection, including those compensated cirrhosis. However, fewer data available more advanced liver disease. Our retrospective, noninterventional, national, multicenter study from the Spanish Hepa-C registry investigated effectiveness safety of interferon-free DAA regimens disease, decompensated cirrhosis, routine practice (all currently approved were registered). Patients...
Drug-induced idiosyncratic liver disease (DIILD) depends largely on host susceptibility factors. Small studies support the genetic influence of human leukocyte antigen (HLA) class II molecules predisposition to DIILD. We sought associations between HLA-DRB and -DQB alleles DIILD considered collectively or according biochemical expression damage. studied a total 140 patients with definitive probable diagnosis DIILD, as assessed Council for International Organizations Medical Sciences scale,...
BACKGROUND The increasing incidence of osteoporotic hip fracture (HF) has raised the requirements red blood cell (RBC) transfusions, whereas this scarce resource may cause morbidity and mortality. STUDY DESIGN AND METHODS This study was a multicenter, randomized, double‐blind, clinical trial that aimed to assess efficacy ferric carboxymaltose (FCM) with or without erythropoietin (EPO) in reducing RBC transfusion perioperative period HF. Participants (patients > 65 years admitted HF...
BACKGROUND: Intensive lipid-lowering therapy may induce coronary atherosclerosis regression. Nevertheless, the factors underlying effect of on disease regression remain poorly characterized. Our aim was to determine which characteristics atherosclerotic plaque are associated with a greater reduction in burden (PB) after treatment alirocumab patients familial hypercholesterolemia. METHODS: The ARCHITECT study (Effect Alirocumab Atherosclerotic Plaque Volume, Architecture and Composition) is...
•This study analyzes event rates of 2 high-potency statins in FH.•LDL-C goal attainment and risk were similar both groups.•LDL-C reduction was greater with rosuvastatin. Events groups.•Event rate 1.1/100 patient-years atorvastatin 1.2 BackgroundMaximal doses potent are the basement treatment familial hypercholesterolemia (FH). Little is known about use different statin regimens FH.ObjectivesThe objectives to describe changes low-density lipoprotein cholesterol (LDL-C) achievement (ATV)...
Abstract Aims Knowledge of the features patients with familial hypercholesterolaemia (FH) who are protected from atherosclerotic cardiovascular disease (ASCVD) is important for clinical and prognostic care this apparently high-risk condition. Our aim was to investigate determinant characteristics FH ASCVD have normal life expectancy, so-called ‘resilient’ (R-FH). Methods results Spanish Familial Hypercholesterolaemia cohort study (SAFEHEART) an open, multicentre, nation-wide, long-term...
Abstract Aims Most heterozygous familial hypercholesterolaemia (FH) patients require intensive lipid-lowering therapy (LLT) including PCSK9 inhibitors (PCSK9is) to reach current low-density lipoprotein cholesterol (LDL-C) goals. Persistence with chronic treatment is important reduce the burden of atherosclerotic cardiovascular disease. We analysed persistence, efficacy, and impact on quality life (QoL) PCSK9i in FH clinical practice setting. Methods results Spanish Familial...
Available data regarding clinical profile and management of elderly patients with atrial fibrillation (AF) according to dependency, fragility cognitive impairment are scarce. The objective the study was analyze biodemographic data, antithrombotic treatment in AF patients.Cross-sectional multi-center performed consecutive ≥ 75 years treated oral anticoagulants 3 months attended Internal Medicine Departments Spain.A total 837 (83.0 ± 5.0 years; CHA2DS2-VASc: 1.4; HAS-BLED: 2.1 0.9) were...
Malignant syphilis is an infrequent manifestation of in HIV infected patients. Only 21 cases have been published medical literature. Most frequent men, 62%, the mean age presentation 34 years. The most symptoms are: 100% ulcerative cutaneous lesions, 47% fever and 33% ocular affectation. About 80% patients a CD4 count >200. Lues serological test was positive 81% responded to penicillin. We report 18 year old woman diagnosed infection, admitted our service because fever, painful oral sores,...
Abstract Background Cardiovascular disease is a major cause of morbidity and mortality in people with HIV. The detection subclinical atherosclerosis through vascular ultrasound allows us to identify patients at an increased risk cardiovascular as primary prevention strategy; this test not routine. Our objective predictors population Methods People HIV infection were selected for underwent carotid femoral detect atheromatous plaques. Logistic regression analysis including factors was...
Around one third to half of patients with hip fractures require red-cell pack transfusion. The increasing incidence fracture has also raised the need for this scarce resource. Additionally, transfusions are not without complications which may involve excessive morbidity and mortality. This makes it necessary develop blood-saving strategies. Our objective was assess safety, efficacy, cost-effictveness combined treatment i.v. ferric carboxymaltose erythropoietin (EPOFE arm) versus (FE a...
BACKGROUND Detecting total cholesterol in dried blood spots could aid identifying individuals with a high likelihood of familial hypercholesterolemia and be used as screening measure. This study aims to assess the diagnostic accuracy on Whatman 903 paper cards using manual enzymatic technique. METHODS A 394 samples collected serum were compared. Cholesterol was determined automated reference method, while measured method. Within- between-day variability analyzed. The correlation between both...
Summary. The significance of Candida albicans in the development denture stomatitis (DS), as well clinical and microbiological efficacy treatment with fluconazole itraconazole was studied 115 patients affected DS 200 controls (100 healthy dental prosthesis 100 without prosthesis). Specimens were taken from all patients; subsequently positive culture group treated fluconazole. A second specimen after 15 days fluconazole, if results again, instituted given appointments for taking a third...