José Miguel Rosales Zábal
A5077599552- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Diet, Metabolism, and Disease
- Gastrointestinal Tumor Research and Treatment
- HIV/AIDS drug development and treatment
- Abdominal vascular conditions and treatments
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Diagnosis and treatment of tuberculosis
- Syphilis Diagnosis and Treatment
- Digestive system and related health
- Drug-Induced Hepatotoxicity and Protection
- Biliary and Gastrointestinal Fistulas
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Metastasis and carcinoma case studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
Hospital Costa del Sol
2009-2025
Agencia Sanitaria Costa del Sol
2011-2024
University Gastroenterology
2018
Abstract Background MASLD can manifest as hepatocellular damage, which result in mild elevation of aminotransferases. However, some patients, presents with cholestatic pattern. Objective To assess the impact biochemical pattern on natural course MASLD, including liver damage histology, accuracy non-invasive tests(NITs), and prognosis. Methods Multicenter study enrolling 2156 patients biopsy-proven who were classified based their[ALT/ULN)]/[(ALP/ULN)] levels at time biopsy: (a) pattern(H),...
Summary Background Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct‐acting antivirals (DAAs). Data are limited on effectiveness of this treatment after current first‐line therapies. Our aim was to analyse safety SOF/VEL/VOX among failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB). Methods Retrospective multicentre study (26 Spanish hospitals), including...
recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, diabetes mellitus, arterial hypertension, renal cardiac disease. Uric is an endogenous danger signal activator of inflammasome, has been independently associated with increased risk cirrhosis.six hundred thirty-four patients from nation-wide HEPAMET registry biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuricemia related advanced liver damage in non-alcoholic fatty disease...
Abstract Objectives To investigate resistance-associated substitutions (RASs) as well retreatment efficacies in a large cohort of European patients with failure glecaprevir/pibrentasvir. Methods Patients were identified from three Resistance Reference centres Spain, Italy and Germany. Sequencing NS3, NS5A NS5B was conducted associated resistance to direct antiviral agents analysed. Clinical virological parameters documented retrospectively evaluated. Results We evaluated 90...
INTRODUCTION: Despite the direct-acting antiviral therapy has dramatically decreased likelihood of having liver-related complications and extrahepatic outcomes, risk developing hepatocellular carcinoma (HCC) is not totally eliminated after sustained virological response (SVR). We aimed to develop an easy-to-apply strategy be adopted in clinical practice for accurately classifying HCC hepatitis C virus patients SVR. METHODS: Prospective multicenter study enrolling with advanced fibrosis...
Summary In randomized controlled trials of patients with chronic HCV infection, elbasvir/grazoprevir ( EBR / GZR ) demonstrated high cure rates and a good safety profile. This study assessed the effectiveness , without ribavirin, in real‐world patient cohort. HEPA ‐C is collaborative, monitored national registry directed by Spanish Association for Study Liver Networked Biomedical Research Centre Hepatic Digestive Diseases. Patients entered into between December 2016 May 2017, treated at...
Abstract Background and Aim Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of leading causes screening failure in clinical trials. We assessed NASH distribution its components across fibrosis stages their impact on prognosis relationship with concept metabolic‐associated fatty liver disease (MAFLD). Methods Spanish multicenter study including 1893 biopsy‐proven (NAFLD) patients from HEPAmet registry. was diagnosed by...
Treatment guidelines differ in their recommendation to determine baseline resistance associated substitutions (RAS) before starting a first-line treatment with direct-acting antivirals (DAAs). Here we analyze the efficacy of DAA RAS information. We conducted prospective study involving 23 centers collaborating GEHEP-004 cohort. Baseline NS5A and NS3 RASs were studied by Sanger sequencing. After issuing comprehensive report, treating physician decided therapy, duration ribavirin use....
To determine the factors associated with an increased risk for severe steatosis (SS) and establish Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool.A cross-sectional study was performed in obese children to assess relationship between metabolic syndrome (MetS) glucose metabolism alterations (GMA) steatosis.A total of 94 (51 males) aged from six 14 years were included. Thirteen (14.8%) had (SS). The anthropometric variables SS included body mass index (BMI) (SS...
The most frequent causes of acute pancreatitis are biliary stones, alcohol consumption, smoking and tumors. Some them do not have any established cause, they catalogued as idiopathic pancreatitis.We report the case a 56-year-old woman with history bilateral adrenalectomy on hormone replacement therapy corticosteroids, who has recurrent episodes mild an etiologic study (laboratory imaging tests) without significant findings. A drug-induced etiology was suspected, so corticosteroids were...