A5101461928- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Neurological Complications and Syndromes
- Dialysis and Renal Disease Management
- T-cell and B-cell Immunology
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Renal and Vascular Pathologies
- Hepatitis C virus research
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Renal Diseases and Glomerulopathies
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Potassium and Related Disorders
- Endoplasmic Reticulum Stress and Disease
- Inflammatory Bowel Disease
- Chronic Kidney Disease and Diabetes
Marqués de Valdecilla University Hospital
2016-2025
Universidad de Cantabria
2007-2025
Instituto de Investigación Marqués de Valdecilla
2016-2025
University of Basrah
2024
Barcelona Institute for Global Health
2023
Universitat de Barcelona
2007-2023
Hospital Ramos Mejía
2023
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017-2022
Instituto de Salud Carlos III
2019-2021
Hospital General Universitario Gregorio Marañón
2018
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis hepatocellular carcinoma globally. This burden is expected to increase as epidemics obesity, diabetes metabolic syndrome continue grow. The goal this analysis was use Markov model forecast NAFLD using currently available data.A used estimate NASH progression in eight countries based on data for adult prevalence obesity type 2 mellitus (DM). Published estimates expert...
There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel (IBD). We aimed to determine MAFLD IBD patients.Cross-sectional, case-control study included all consecutive treated at 2 different university hospitals. Controls were subjects randomly selected from general population matched by age, sex, type diabetes status, body mass index a 1:2 ratio. was confirmed controlled attenuation...
Early identification of those with NAFLD activity score ≥ 4 and significant fibrosis (≥F2) or at-risk metabolic dysfunction-associated steatohepatitis (MASH) is a priority as these patients are at increased risk for disease progression may benefit from therapies. We developed validated highly specific metabolomics-driven to identify MASH.
The long-term outcomes of kidney transplantation are suboptimal because many patients lose their allografts or experience premature death. Cross-country comparisons may provide insight into factors contributing to graft failure and We evaluated the rates late death among US Spanish recipients. This is a cohort study (n = 9609) 3808) who received deceased donor transplant in 1990, 1994, 1998 2002 had functioning allograft 1 year after with follow-up through September 2006. Ten-year overall...
increasing evidence suggests a role of intestinal dysbiosis in obesity and non-alcoholic fatty liver disease (NAFLD). The advances recent years with regard to the gut microbiota raise potential utility new therapeutic approaches based on modification microbiome.the aim this study was compare bacterial communities obese patients or without NAFLD those healthy controls.the fecal composition 20 adults, 36 17 determined by 16S ribosomal RNA sequencing using Illumina MiSeq system.the results...
We aimed to assess the role of FGF21 in metabolic dysfunction-associated steatotic liver disease (MASLD) at a multi-scale level.
Hypertension is a common complication after renal transplantation and associated with increased mortality. Cyclosporine known to be nephrotoxic raises blood pressure in recipients of cardiac bone marrow transplants, but there conflicting data on the role cyclosporine transplantation. We have examined this question patients entered into second Oxford prospective randomized comparison short-term treatment alone conversion azathioprine prednisolone at 90 days (CsA group), conventional therapy...
Background. Monitoring changes in glomerular filtration rate (GFR) is the recommended method for assessing progression of kidney disease. The aim this study was to assess decline graft function defined by annualized change GFR and factors which affect it.
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and common event in acute liver injury/failure chronic disease. Even though hepatic are potential predictive factors patient outcome, easy inexpensive methods aiming at the detection accumulation clinical setting remain unavailable. Thus, herein we have developed morphological method, based on utilization Nessler´s reagent, to accurately precisely detect biological tissue. We validated our method against...
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved orchestrating immune response against cytomegalovirus (CMV) and 12-month incidence of CMV infection 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. occurred 140 patients (44.4%), including 13 episodes disease. After adjusting for various clinical covariates, harboring T-allele genotypes...
Abstract There is a need, in NAFLD management, to develop non-invasive methods detect steatohepatitis (NASH) and predict advanced fibrosis stages. We evaluated tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH detection by investigating patients with biopsy-proven who underwent (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging (NASHMRI FibroMRI) were developed, standardised validated area under the receiver operating...
Some chronic inflammatory skin diseases, such as psoriasis, have been associated with an increased prevalence of non-alcoholic fatty liver disease (NAFLD). Nevertheless, this in hidradenitis suppurativa (HS) has not assessed to date.To determine the NAFLD patients HS and risk factors disorder.This case-control study enrolled 70 150 age- gender-matched controls who were evaluated by hepatic ultrasonography (US) transient elastography (TE) after excluding other secondary causes disease. The...
Non-alcoholic fatty liver disease (NAFLD) has become a major public health problem, but the prevalence of fibrosis associated with non-alcoholic steatohepatitis (NASH) is largely unknown in general population. This study aimed to provide an updated estimation NASH Spain.This was observational, retrospective, cross-sectional, population-based merged data from two Spanish datasets: large (N = 12 246) cohort (ETHON), including transient elastography (TE) data, and contemporary multi-centric...