A5030698240- Lipid metabolism and disorders
- Diet and metabolism studies
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Bone health and osteoporosis research
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Parathyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Health and Disease Prevention
- Sexual Differentiation and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obesity and Health Practices
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Pituitary Gland Disorders and Treatments
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- Blood Pressure and Hypertension Studies
University of Alabama at Birmingham
2015-2024
Children's of Alabama
2011-2022
University of Alabama
2006-2021
St. Vincent's Birmingham
2005-2019
Pediatrics and Genetics
2017
Emory University
2012
Children's Hospital
2006
Vitamin D functions are not limited to skeletal health benefits and may extend preservation of insulin secretion sensitivity. This review summarizes the literature related potential vitamin influences on glucose homeostasis Cross-sectional data provide some evidence that circulating 25-hydroxyvitamin (25(OH)D) is inversely associated with resistance, although direct measurements sensitivity required for confirmation. Reported associations secretion, however, contradictory. Available...
Circulating FGF21 levels are commonly elevated in disease states. There is limited information regarding concentrations of circulating the absence disease, as well age-related differences body composition that may contribute to regulation across groups.The objectives this study were assess age groups (childhood elder adulthood), and investigate whether indices associated with FGF21.We cross-sectionally analyzed serum 184 healthy subjects aged 5-80y (45% male). Multiple linear regression was...
Familial chylomicronemia syndrome (FCS) is an ultrarare inherited disorder. Genetic testing not always feasible or conclusive. European clinicians developed a "FCS score" to differentiate between FCS and multifactorial (MCS), more common condition with overlapping features. A diagnostic score has been for use in the North American (NA) context. To develop validate NA patients based on signs, symptoms biochemical traits of FCS. Using RAND/UCLA modified Delphi process, we convened 10...
Vitamin D status can influence insulin resistance.The aim of the study was to determine prevalence vitamin deficiency in obese African-American (AA) adolescent females a southeastern latitude and relationship 25-hydroxyvitamin [25(OH)D] with glucose dynamics.We conducted cross-sectional University Children's Hospital.Serum 25(OH)D, fasting glucose, PTH, serum calcium, lipids, transaminases, C-reactive protein were assessed. Indices sensitivity resistance determined from an oral tolerance...
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common form of among adolescents in industrialized countries. While lifestyle intervention remains hallmark treatment for NAFLD, effective dietary strategy to reverse NAFLD children is unknown.The objective this study was determine effects a moderately CHO-restricted diet (CRD) vs fat-restricted (FRD) with on reduction fat and insulin resistance.Thirty-two children/adolescents (age 9-17) obesity were randomized CRD...
There is concern that the growing incidence of pediatric type 2 diabetes (T2D) may have been further exacerbated by COVID-19 pandemic.To examine whether trends in new-onset T2D-inclusive patients requiring hospitalization and managed as outpatients-were impacted during pandemic, to compare patient characteristics prior COVID-19.A retrospective single-center medical record review was conducted a hospital which cares for 90% Alabama's T2D patients. Patients with referred from March 2017 2021...
Vitamin D deficiency may increase the risk for metabolic syndrome. We determined relationship of serum 25-hydroxyvitamin (25(OH)D) with syndrome components in obese adolescent females and assessed whether vitamin treatment corrects disturbances. Eighty postmenarchal adolescents (53 African American (AA) 27 Caucasian (CA)) were evaluated blood pressures fasting measurements 25(OH)D, lipid profile, C-reactive protein, alanine transaminases (ALTs) aspartate followed by an oral glucose tolerance...
We hypothesized that, similar to the coordinated homeostatic regulation of most hormones, concentration free and bioavailable 25-hydroxyvitamin D [25(OH)D] will be tightly controlled by total 25(OH)D vitamin binding protein (VDBP) that VDBP concentrations associated with insulin resistance status.Our primary objective was investigate associations between total, free, VDBP. also evaluated relationships indices.The study design cross-sectional in setting a university children's hospital. The...
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In patients with X-linked hypophosphatemia (XLH), conventional therapy oral phosphate salts and active vitamin D has been associated nephrocalcinosis. However, the nature of relationships among XLH, its treatment, nephrocalcinosis, kidney function remain poorly understood.
Abstract : To determine the effects of metformin therapy in children with metabolic syndrome (MS). A retrospective electronic chart review aged 8–18 years, from 2000 to 2012 a diagnosis code for MS (ICD 277.7) that met modified NCEP ATPIII criteria MS. There were total 217 subjects, 150 non-metformin [untreated group (UTG)] and 67 treated (MTG). At baseline, MTG had body mass index (BMI) similar UTG, but higher cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high density...