A5071185417- Rheumatoid Arthritis Research and Therapies
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Chronic Disease Management Strategies
- Lymphoma Diagnosis and Treatment
- Epilepsy research and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Childhood Cancer Survivors' Quality of Life
- Emergency and Acute Care Studies
- Innovations in Medical Education
- Lipid metabolism and disorders
- Iron Metabolism and Disorders
- Metabolism, Diabetes, and Cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Dermatological and Skeletal Disorders
- Complement system in diseases
- Nausea and vomiting management
- Clinical Laboratory Practices and Quality Control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Partnership for Health Analytic Research
2019-2024
University of Manitoba
2023
Augusta University
2022
University of Georgia
2022
Sheffield Children's Hospital
2019
Queen's Hospital
2013
Abstract: The RAND/UCLA modified Delphi panel method is a formal group consensus process that systematically and quantitatively combines expert opinion evidence by asking panelists to rate, discuss, then re-rate items. has been used develop medical society guidelines, other clinical practice disease classification systems, research agendas, quality improvement interventions. Traditionally, of experts meet in person discuss results first-round survey. After the meeting, complete second-round...
Familial chylomicronemia syndrome (FCS) is an ultrarare inherited disorder. Genetic testing not always feasible or conclusive. European clinicians developed a "FCS score" to differentiate between FCS and multifactorial (MCS), more common condition with overlapping features. A diagnostic score has been for use in the North American (NA) context. To develop validate NA patients based on signs, symptoms biochemical traits of FCS. Using RAND/UCLA modified Delphi process, we convened 10...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, non-malignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, and bone marrow dysfunction. The development of complement inhibitors has transformed outcomes for patients with PNH, but may still experience pharmacodynamic breakthrough (BTH), which can be caused exposure amplifying condition (CAC), such as vaccination, infection, surgery.
Abstract Severe aplastic anemia (SAA) is a rare hematologic condition for which there no clear management algorithm. A panel of 11 experts on adult and pediatric was assembled and, using the RAND/University California, Los Angeles modified Delphi method, evaluated >600 varying patient care scenarios to develop clinical recommendations initial subsequent patients all ages with SAA. Here, we present panel’s rule out inherited bone marrow failure syndromes, supportive before during...
Background Migraine is associated with debilitating symptoms that can affect daily functioning. “My Voice” was a large, cross‐sectional, multi‐country online survey aimed at understanding disease burden directly from people migraine. Objective This study reports on the social and economic impacts of migraine, specifically impact activities living costs point view migraine in United States. Methods The administered to adults self‐reported diagnosis who experienced 4 or more monthly days each...
Abstract Background Neurotrophic keratopathy (NK) is a relatively uncommon, underdiagnosed degenerative corneal disease that caused by damage to the ophthalmic branch of trigeminal nerve conditions such as herpes simplex or zoster keratitis, intracranial space-occupying lesions, diabetes, neurosurgical procedures. Over time, epithelial breakdown, ulceration, melting (thinning), perforation, and loss vision may occur. The best opportunity reverse ocular surface in earliest stage NK. However,...
There is no well-accepted classification system of overall sickle cell disease (SCD) severity. We sought to develop a that could be tested as clinical outcome predictor.Using validated methodology (RAND/UCLA modified Delphi panel), 10 multi-disciplinary expert clinicians collaboratively developed 180 simplified patient histories and rated each on multiple axes (estimated clinician follow-up frequency, risk complications or death, quality life, severity). Using ratings severity, we 3-level...
Thrombopoietin receptor agonists (TPO-RAs) are used to treat primary immune thrombocytopenia (ITP). Some patients have discontinued treatment while maintaining a hemostatic platelet count.
Simulation is increasingly being used in the preclinical years of US medical school curricula to provide experiential learning opportunities for students. However, students may not be able access full benefits immersive simulation scenarios without an in-depth introduction environment and manikin. An escape room effective way orient interactive manner overcome this barrier.We designed implemented a 90-minute orientation activity address student discomfort by providing team-based, hands-on...
Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset before 18 years age, estimated to account for 2% 5% population worldwide. Objectives: To conduct literature review focused on healthcare resource utilization and cost well quality-of-life (QOL) outcomes among patients with POMS. Methods: We conducted systematic English-language studies published after September 2010 in MEDLINE Embase...
On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them.Develop expert consensus determine appropriate clinical factors for considering on-demand treatments.Using a RAND/UCLA modified Delphi panel method, developed on the use of episodes.The agreed were associated with greater functional impact and interfered basic daily activities. The also treatment may be patients morning akinesia and/or delayed ON first...
e18584 Background: Cancer progression rates following diagnosis are readily measured. However, the rate of cancer during preclinical sojourn time is generally unobserved. Understanding duration stages (“dwell time”) would allow clinicians to better identify appropriate screening intervals for cancer. We therefore elicited estimates a wide variety malignancies from panel clinical experts. Methods: used validated consensus methodology (RAND/UCLA modified Delphi method) elicit per-stage dwell...
Objective(s): PIK3CA-related overgrowth spectrum (PROS) is a group of disorders caused by somatic variants in the PIK3CA gene. We aimed to update recommendations on severity classification, testing, and medical management patients with PROS. Methods: Using validated consensus methodology, we convened 13-member panel 2020 reviewed current evidence how diagnose treat The was asked rate level disease severity, appropriateness whether test for mutation therapy 217 patient scenarios before...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset before 18 years age, estimated to account for 2% 5% population worldwide.
Abstract Background Alternative funding programs (AFPs) seek to reduce plan sponsor costs by excluding specialty drugs from a beneficiary’s coverage and requiring patients obtain medications through alternative sources (typically, the manufacturer’s patient assistance [PAPs]) via an AFP vendor as third-party). Objective To describe patients’ experiences medication access with AFPs, which have not been explored previously. Methods A survey instrument consisting of optional single-...
Alternative funding programs (AFPs) seek to reduce health plan sponsor costs, for example by excluding specialty drugs from a beneficiary's coverage and requiring patients obtain medications through alternative sources (typically, the manufacturer's patient assistance programs) via an AFP vendor as third-party.
Abstract Study Objective Patients with sickle cell disease (SCD) have many emergency department visits because of painful vaso‐occlusive episodes (VOE). Guidelines recommend treatment within 30 minutes triage, but this is rarely achieved in clinical practice. Our goal was to develop an order set that being implemented the ED facilitate and standardize care for SCD patients acute pain from VOEs presenting (ED) New York City (NYC). Methods Using a RAND/University California, Los Angeles...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling and destruction that leads to severe disability. There are no clear guidelines regarding the order of therapies. Gathering data on treatment patterns outside clinical trial setting can provide useful context for clinicians.
<h3>Background</h3> Over the last 5 years, attendances at major emergency departments (ED) have increased by 3000 patients per day. Primary care streaming has potential to mitigate this demand. However, while one UK study in a tertiary paediatric ED found that co-located General Practitioner (GP) significantly reduced waiting times and admissions, Cochrane review concluded there is lack of evidence support effectiveness primary services ED. <h3>Aim</h3> To evaluate impact on service for...