A5086412697- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
- Vascular Malformations Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Vascular Anomalies and Treatments
- Histiocytic Disorders and Treatments
- Tracheal and airway disorders
- Sharing Economy and Platforms
- Central Venous Catheters and Hemodialysis
- Tuberous Sclerosis Complex Research
- Oral and gingival health research
- Parvovirus B19 Infection Studies
- CNS Lymphoma Diagnosis and Treatment
- Vascular anomalies and interventions
- Teratomas and Epidermoid Cysts
- Neuroblastoma Research and Treatments
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Moyamoya disease diagnosis and treatment
- Head and Neck Surgical Oncology
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Neonatal skin health care
- Lysosomal Storage Disorders Research
- Diabetes Treatment and Management
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati Medical Center
2017-2025
University of Cincinnati
2014-2024
Cincinnati Sportsmedicine and Orthopaedic Center
2019
Research Network (United States)
2018
Boston Children's Hospital
2016
Harvard University
2016
The University of Texas Southwestern Medical Center
1999-2002
Complicated vascular anomalies have limited therapeutic options and cause significant morbidity mortality. This Phase II trial enrolled patients with complicated to determine the efficacy safety of treatment sirolimus for 12 courses; each course was defined as 28 days.Treatment consisted a continuous dosing schedule oral starting at 0.8 mg/m(2) per dose twice daily, pharmacokinetic-guided target serum trough levels 10 15 ng/mL. The primary outcomes were responsiveness by end 6 (evaluated...
Abstract Background Vascular anomalies comprise a diverse group of diagnoses. While infantile hemangiomas are common, the majority these conditions quite rare and have not been widely studied. Some lesions, though benign, can impair vital structures, be deforming, or even become life‐threatening. tumors such as kaposiform hemangioendotheliomas (KHE) complicated vascular malformations proven particularly difficult to treat. Procedure Here we retrospectively evaluate series six patients with...
Description: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease with estimated prevalence of 1 in 5000 that characterized by the presence vascular malformations (VMs). These result chronic bleeding, acute hemorrhage, and complications from shunting through VMs. The goal Second International HHT Guidelines process was to develop evidence-based consensus guidelines for management prevention HHT-related symptoms complications. Methods: were developed using AGREE II...
Abstract Background Generalized lymphatic anomaly (GLA) and Gorham–Stout disease (GSD) are rare complicated malformations that occur in multiple body sites associated with significant morbidity mortality. Treatment options have been limited, conventional medical therapies generally ineffective. Emerging data suggest a role for sirolimus as treatment option complex anomalies. Procedure Disease response was evaluated by radiologic imaging, quality of life (QOL), clinical status assessments...
Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation involving predominantly the skin and gastrointestinal tract. Traditional treatment modalities include corticosteroids, interferon-α, sclerotherapy, aggressive surgical resection. Sirolimus has been used in several single case reports.We performed single-institution retrospective review of four children with BRBNS, who received sirolimus as part their regimens. A diagnosis BRBNS was based on clinical, radiologic,...
Sirolimus has recently been shown to be efficacious and tolerable in pediatric patients with complicated vascular anomalies. Nevertheless, dosing information remains very limited especially for neonates infants. The purpose of this study was develop an age-appropriate sirolimus starting regimen based on the developmental changes drug elimination capacity using data collected infants.A developed maturation model [Emoto et al. CPT Pharmacometrics Syst Pharmacol, 2016] used simulate clearance...
We describe a child initially diagnosed with multi-focal infantile hemangioma (cutaneous, hepatic, pulmonary), benign vascular lesion, which underwent malignant transformation to angiosarcoma. The use of anti-angiogenic agents, such as bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, has been reported in adults Treatment chemotherapy (gemcitabine and docetaxel) bevacizumab resulted disease response progression free survival 12 months. This report describes the...
Abstract Background Capillary lymphatic venous malformations (CLVM) and associated syndromes, including Klippel–Trenaunay syndrome (KTS) congenital lipomatous overgrowth, vascular malformation, epidermal nevi, skeletal, spinal (CLOVES), are underrecognized disorders with high morbidity from chronic pain, recurrent infections, bleeding, clotting complications. The rarity of these heterogeneity clinical presentations make large‐scale randomized drug trials challenging. Identification PIK3CA...
Abstract Hereditary hemorrhagic telangiectasia (HHT), the second most common inherited bleeding disorder, is associated with development of malformed blood vessels. Abnormal vessels may be small and cutaneous or mucosal (telangiectasia), frequent complications bleeding, large visceral (arteriovenous malformations [AVMs]), additional risks that can lead to significant morbidity even mortality. HHT present in many different ways difficult recognize, particularly younger patients absence a...
Vascular malformations are defects caused by the abnormal growth of vasculature. Among them, venous malformation (VM) is an anomaly characterized slow-flow vascular lesions with abnormally shaped veins, typically in sponge-like configuration. VMs can expand over years causing disfigurement, obstruction vital structures, thrombosis, bleeding, and pain. Treatments have been very limited primarily based on supportive care, compression garments, sclerotherapy, and/or surgical resection....