Miguel García Deltoro
A5038008037- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Biochemical and Molecular Research
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Sex work and related issues
- Herpesvirus Infections and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Poisoning and overdose treatments
- Virology and Viral Diseases
- Poxvirus research and outbreaks
- Dermatological and COVID-19 studies
- Hepatitis Viruses Studies and Epidemiology
- Alcohol Consumption and Health Effects
Hospital General Universitario De Valencia
2016-2025
Universitat de València
2021-2025
Brighton and Sussex Medical School
2023
Queen Mary University of London
2023
Yale University
2023
Imperial College London
2023
Weatherford College
2022
Hospital Universitari de Vic
2021-2022
Sociedad Española de Medicina Interna
2018
Hospital Regional Universitario de Málaga
2016
•An international cohort of 3,355 patients with hepatitis C from 22 countries was evaluated for drug resistance following DAA therapy.•Nearly all harbored drug-resistant variants after treatment failure, over 2/3 having against ≥2 classes.•Pathways to included enrichment highly resistant and selection multiple variants.•Previously unrecognized in who failed NS5A inhibitors were identified at high frequencies.•Resistance frequent older people cirrhosis those infected genotypes 1b 4 failure....
Few antiviral therapies have been studied in patients with coronavirus disease 2019 (COVID-19) and kidney impairment. Herein, the efficacy, safety, pharmacokinetics of remdesivir, its metabolites, sulfobutylether-β-cyclodextrin excipient were evaluated hospitalized COVID-19 severe In REDPINE, a phase 3, randomized, double-blind, placebo-controlled study, participants aged ≥12 years for pneumonia acute injury, chronic disease, or failure randomized 2:1 to receive intravenous remdesivir (200...
This was a study of monkeypox-infected patients in tertiary care center Spain describing the epidemiologic, clinical, and microbiologic features 49 patients. Background Monkeypox is previously rare viral zoonosis affecting predominantly African continent. Since May 2022, an increasing number cases with no known epidemiologic link to Africa have been reported for first time rest world. Methods We described clinical characteristics all attended at our until August 9 confirmed diagnosis...
Abstract Background Cabotegravir + rilpivirine (CAB RPV) administered via intramuscular gluteal injections is the first complete long-acting regimen for maintaining human immunodeficiency virus type 1 (HIV-1) virologic suppression. We present substudy results on short-term repeat CAB RPV thigh in participants with ≥3 years of experience administration during ATLAS–2M study. Methods Substudy phases included screening, injection (day 1–week 16), and return to (week 16–week 24). The schedule...
Hepatitis delta virus (HDV) is the most aggressive form of chronic viral hepatitis, yet substantial knowledge gaps exist regarding its epidemiology and optimal diagnostic workflows. From February 2019 to March 2022, an HBV screening project was conducted across various healthcare settings in Valencia, Spain. This included twenty-six primary care centers, six sexual reproductive health three mental addiction treatment selected hospital departments, outpatient clinics, a penitentiary center. A...
Background Pre-exposure prophylaxis (PrEP) is an effective and cost-effective strategy for HIV prevention. Spain carried out implementation study in order to assess the feasibility of implementing PrEP programmes within its heterogeneous health system. Methods Observational longitudinal conducted on four different types health-care setting: a community centre (CC), sexually transmitted infections clinic (STIC), hospital-based unit (HBHIVU) STI (HBSTIU). We recruited gay, bisexual other men...
Abstract Our study assessed the characteristics of people living with HIV (PLWH) detected via opportunistic screening in Valencia (Spain) to determine diagnoses potentially missed under a more restrictive, indicator-condition diagnostic strategy. We conducted retrospective analysis electronic health records 97 PLWH diagnosed between April 2019 and August 2022. The main outcomes reported were patient CD4 + T cell count, known risk factors at diagnosis, opportunities for defined as failure...
Long-acting injectable antiretroviral therapy has been shown to be non-inferior daily oral in clinical trials and may soon become part of care. While most trial participants date have men, approximately one quarter ongoing Phase 3 are women offering an important opportunity understand how long-acting is perceived experienced by women. We conducted in-depth interviews with 80 people living HIV participating 2 the USA Spain. Fifteen percent (12/80) interviewed were Interviews audio-recorded,...
The fibrogenesis analysis in quimeric CCR1 and CCR5 mice revealed that mediates its pro-fibrogenic effects hepatic cells promoting stellate cells. blockage of co-receptors could preserve the progression fibrosis HIV/HCV co-infected patients.To evaluate beneficial on patients are antiretroviral therapy (ART) with co-receptor antagonists.A multicentre, retrospective pilot study evaluation at mid- long-term by non-invasive methods a cohort Valencian Community (Spain) received ART antagonist....
Abstract Objectives To investigate resistance-associated substitutions (RASs) as well retreatment efficacies in a large cohort of European patients with failure glecaprevir/pibrentasvir. Methods Patients were identified from three Resistance Reference centres Spain, Italy and Germany. Sequencing NS3, NS5A NS5B was conducted associated resistance to direct antiviral agents analysed. Clinical virological parameters documented retrospectively evaluated. Results We evaluated 90...
ABSTRACT Background Nonalcoholic fatty liver disease (NAFLD) is an increasing concern for people living with HIV (PLWH). However, information on the impact of NAFLD prognosis PLWH very scarce. Aims To investigate influence overall and liver‐related mortality in PLWH. Methods followed three Spanish centres were included a prospective cohort at date first transient elastography evaluation. Survival data recorded, causes death centrally monitored. The risk all‐cause was evaluated by applying...