A5088490080- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemoglobin structure and function
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Inflammatory Bowel Disease
- Lipoproteins and Cardiovascular Health
- Pharmacogenetics and Drug Metabolism
- Cannabis and Cannabinoid Research
- Liver Disease and Transplantation
- Trace Elements in Health
- Pancreatitis Pathology and Treatment
- Biomedical Research and Pathophysiology
- Silymarin and Mushroom Poisoning
- Diet and metabolism studies
Charles University
2016-2025
General University Hospital in Prague
2015-2025
LGBT Foundation
2021
Ministry of Health Labour and Welfare
2020
National Heart Foundation of Australia
2013
University of Copenhagen
2013
Bispebjerg Hospital
2013
Medical University of Vienna
2013
Griffith University
2013
Rigshospitalet
2013
Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed be only waste product the heme catabolic pathway at best, and potentially toxic compound worst; recent data has convincingly demonstrated that mildly elevated serum levels are strongly associated with lower prevalence oxidative stress-mediated diseases. Indeed, been consistently shown negatively correlated cardiovascular...
Carbon monoxide-releasing molecules (CORMs) are chemical agents used to administer CO as an endogenous, biologically active molecule. A precise spatial and temporal control over the release is major requirement for their applications. Here, we report synthesis properties of a new generation transition-metal-free carbon based on BODIPY chromophores (COR-BDPs) activatable by visible-to-NIR (up 730 nm) light. We demonstrate performance both in vitro vivo experimental settings, propose mechanism...
Spirulina platensis is a blue-green alga used as dietary supplement because of its hypocholesterolemic properties. Among other bioactive substances, it also rich in tetrapyrrolic compounds closely related to bilirubin molecule, potent antioxidant and anti-proliferative agent. The aim our study was evaluate possible anticancer effects S. platensis-derived tetrapyrroles using an experimental model pancreatic cancer. components [phycocyanobilin (PCB) chlorophyllin, surrogate molecule for...
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic worldwide and includes a broad spectrum histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic (NAFL) to steatohepatitis (NASH). While biopsy reference gold standard for NAFLD diagnosis staging, it has limitations due its sampling variability, invasive nature, high cost. Thus, there need noninvasive biomarkers that are robust, reliable, cost effective. In this study, we measured 540 lipids amino...
Heme oxygenase-1 (HO-1, HMOX1) can prevent tumor initiation; while in various tumors, it has been demonstrated to promote growth, angiogenesis, and metastasis. Here, we investigated whether HMOX1 modulate microRNAs (miRNAs) regulate human non-small cell lung carcinoma (NSCLC) development.Stable overexpression NSCLC NCI-H292 cells up-regulated tumor-suppressive miRNAs, whereas significantly diminished the expression of oncomirs angiomirs. The most potently down-regulated was miR-378. also...
Abstract Background and aims: Wilson disease (WD) is an inherited disorder of copper metabolism. When treated, the outcome can be excellent, although long‐term survival has yet to well documented. The aim this study was describe a cohort patients with WD assess those factors affecting phenotypic manifestation WD. Methods: presence mutations ATP7B gene, clinical manifestations, treatments outcomes were analysed retrospectively in 117 (59 men 58 women, aged at evaluation 38.5 ± 11, range 16–63...
Objective Fibroblast growth factor (FGF)‐19 and FGF‐21 are novel metabolic regulators that improve insulin resistance obesity in rodents. The aim of the study was to assess effects laparoscopic sleeve gastrectomy (LSG) on serum concentrations FGF‐19 along with circulating bile acids other relevant hormonal biochemical parameters. Design Methods Seventeen females undergoing LSG 15 lean healthy were included into study. Anthropometric parameters, ‐21, insulin, adiponectin, leptin, C‐reactive...
Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds are structurally related to heme bilirubin (a bile pigment with activity) among molecules purportedly responsible for these effects. Therefore, the aim of our study was assess both antiproliferative antioxidative effects chlorophylls (chlorophyll a/b, chlorophyllin, pheophytin a) experimental pancreatic Chlorophylls...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic disease. n‐3 polyunsaturated acids (n‐3‐PUFAs) have been reported to ameliorate progression of NAFLD in experimental studies; however, clinical trials yielded contradictory results. The aim our study was assess effects n‐3‐PUFA administration on lipid metabolism and patients with metabolic syndrome. Sixty syndrome were randomized a double‐blind placebo‐controlled trial (3.6 g/day vs. placebo). During 1‐year follow‐up,...
We previously identified subsets of patients with NAFLD different metabolic phenotypes. Here we align metabolomic signatures cardiovascular disease (CVD) and genetic risk factors.