A5041415326- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Thermal Regulation in Medicine
- Telomeres, Telomerase, and Senescence
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
- Hemoglobin structure and function
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Nanoplatforms for cancer theranostics
- Neonatal Health and Biochemistry
- Air Quality and Health Impacts
- Glioma Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphatic System and Diseases
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- Cancer-related cognitive impairment studies
- CRISPR and Genetic Engineering
- Inflammatory Biomarkers in Disease Prognosis
Narodowy Instytut Leków
2023
Jagiellonian University
2008-2022
Wojskowy Instytut Medycyny Lotniczej
2017-2022
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2013-2019
Polish Academy of Sciences
2015-2017
Institute of Neurobiology
2015
Charles University
2010
University of Vienna
2010
University of Łódź
2010
Stromal cell–derived factor 1 (SDF-1) plays a major role in the migration, recruitment, and retention of endothelial progenitor cells to sites ischemic injury contributes neovascularization. We provide direct evidence demonstrating an important for heme oxygenase (HO-1) mediating proangiogenic effects SDF-1. Nanomolar concentrations SDF-1 induced HO-1 through protein kinase C ζ–dependent vascular growth factor–independent mechanism. SDF-1–induced tube formation migration was impaired...
Heme oxygenase-1 (HO-1, HMOX1) can prevent tumor initiation; while in various tumors, it has been demonstrated to promote growth, angiogenesis, and metastasis. Here, we investigated whether HMOX1 modulate microRNAs (miRNAs) regulate human non-small cell lung carcinoma (NSCLC) development.Stable overexpression NSCLC NCI-H292 cells up-regulated tumor-suppressive miRNAs, whereas significantly diminished the expression of oncomirs angiomirs. The most potently down-regulated was miR-378. also...
Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise some doubts concerning effectiveness senescence-induced therapy. Similarly, it postulated that polyploidization connected with disease relapse. We postulate associated culprit atypical divisions leading regrowth. Accordingly, we aimed dissociate between these two phenomena. induced in...
Heme oxygenase-1 (HO-1), a cytoprotective, pro-angiogenic and anti-inflammatory enzyme, is strongly induced in injured tissues. Our aim was to clarify its role cutaneous wound healing. In wild type mice, maximal expression of HO-1 the skin observed on 2(nd) 3(rd) days after wounding. Inhibition by tin protoporphyrin-IX resulted retardation closure. Healing also delayed deficient where lack could lead complete suppression reepithelialization formation extensive lesions, accompanied impaired...
Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression induced in response oxidative stress. Its overexpression has been suggested as strategy improving survival of transplanted muscle precursors.Here we demonstrated that HMOX1 inhibits differentiation myoblasts modulates miRNA processing: downregulates Lin28 DGCR8, lowers the total pool cellular miRNAs, specifically blocks induction myomirs. Genetic or...
Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, the number of GT repeats can influence occurrence cardiovascular diseases. We elucidated effect this polymorphism on endothelial cells isolated from newborns different genotypes.On basis expression, we classified alleles into 3 groups: short (S) (most active, < or = 23), medium (moderately GT=24 28), long...
The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with median survival 14.6 months, carries dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alterations, affecting patient treatment response. Epigenetic mechanisms deregulated in GBM as result aberrant expression/activity enzymes, including histone deacetylases (HDAC) which remove acetyl groups from histones regulating chromatin accessibility. Nevertheless, the impact class/isoform-selective...
Colorectal cancer (CRC) is the second leading cause of death among patients in Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, response to chemotherapy, cells may undergo stress-induced premature senescence (SIPS), which typically results growth arrest. Nonetheless, these senescent were reported divide an atypical manner and thus contribute re-growth. Therefore, we examined if SIPS escape follow treatment with chemotherapeutics...
Anticancer therapies that induce DNA damage tend to trigger senescence in cancer cells, a process known as therapy-induced (TIS). Such cells may undergo atypical divisions, thus contributing tumor re-growth. Accumulation of senescent reduces survival patients after chemotherapy. As interplays with autophagy, dynamic recycling process, we sought study whether inhibition autophagy interferes divisions TIS cells. We exposed human colon HCT116 repeated cycles chemotherapeutic agent - doxorubicin...
Abstract Background HO-1 participates in the degradation of heme. Its products can exert unique cytoprotective effects. Numerous tumors express high levels indicating that this enzyme might be a potential therapeutic target. In study we decided to evaluate cytostatic/cytotoxic effects zinc protoporphyrin IX (Zn(II)PPIX), selective inhibitor and its antitumor activity combination with chemotherapeutics. Methods Cytostatic/cytotoxic Zn(II)PPIX were evaluated crystal violet staining clonogenic...
Heme oxygenase-1 (HO-1) is an antioxidative and cytoprotective enzyme, which may protect neoplastic cells against anticancer therapies, thereby promoting the progression of growing tumors. Our aim was to investigate role HO-1 in cancer induction. Experiments were performed HO-1(+/+), HO-1(+/-), HO-1(-/-) mice subjected chemical induction squamous cell carcinoma with 7,12-dimethylbenz[a]anthracene phorbol 12-myristate 13-acetate. Measurements genes livers evidenced systemic oxidative stress...
Chemotherapy is the commonly used treatment for advanced lung cancer. However, it produces side effects such as development of chemoresistance. A possible responsible mechanism may be therapy-induced senescence (TIS). TIS cells display increased senescence-associated β-galactosidase (SA-β-gal) activity and irreversible growth arrest. recent data suggest that can reactivate their proliferative potential lead to cancer recurrence. Our previous study indicated reactivation proliferation by...
Proangiogenic enzyme thymidine phosphorylase (TP) is a promising target for anticancer therapy, yet its action in non-small cell lung carcinoma (NSCLC) not fully understood. To elucidate role NSCLC tumor growth, NCI-H292 mucoepidermoid cells and endothelial were engineered to overexpress TP by viral vector transduction. with altered expression of transcription factor Nrf2 or gene heme oxygenase-1 (HO-1) used study the regulation findings from pre-clinical models related data clinical...
Natural compounds, such as resveratrol (Res), are currently used adjuvants for anticancer therapies. To evaluate the effectiveness of Res treatment ovarian cancer (OC), we screened response various OC cell lines to combined with cisplatin (CisPt) and Res. We identified A2780 cells most synergistically responding, thus optimal further analysis. Because hypoxia is hallmark solid tumor microenvironment, compared effects alone in combination CisPt (pO2 = 1%) vs. normoxia 19%). Hypoxia caused an...