A5043992991- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Thermal Regulation in Medicine
- Aortic aneurysm repair treatments
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- High Altitude and Hypoxia
- Inflammatory mediators and NSAID effects
- Alcohol Consumption and Health Effects
- Peroxisome Proliferator-Activated Receptors
- Redox biology and oxidative stress
- Neonatal Health and Biochemistry
- Glutathione Transferases and Polymorphisms
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- Macrophage Migration Inhibitory Factor
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Burn Injury Management and Outcomes
- Aortic Disease and Treatment Approaches
- Metabolism, Diabetes, and Cancer
- Cardiac Arrest and Resuscitation
Jagiellonian University
2016-2025
University of Gdańsk
2023
Medical University of Vienna
2019
Charles University
2010
University of Vienna
2010
University of Łódź
2010
Stromal cell–derived factor 1 (SDF-1) plays a major role in the migration, recruitment, and retention of endothelial progenitor cells to sites ischemic injury contributes neovascularization. We provide direct evidence demonstrating an important for heme oxygenase (HO-1) mediating proangiogenic effects SDF-1. Nanomolar concentrations SDF-1 induced HO-1 through protein kinase C ζ–dependent vascular growth factor–independent mechanism. SDF-1–induced tube formation migration was impaired...
Background The transcription factor Nrf2 (NF-E2-related 2) and its target gene products, including heme oxygenase-1 (HO-1), elicit an antioxidant response that may have therapeutic value for Parkinson's disease (PD). However, HO-1 protein levels are increased in dopaminergic neurons of (PD) patients, suggesting participation free-iron deposition, oxidative stress neurotoxicity. Before targeting PD therapy it is imperative to determine if neurotoxic or neuroprotective the basal ganglia....
Nuclear factor E2-related 2 (Nrf2), a key cytoprotective transcription factor, regulates also proangiogenic mediators, interleukin-8 and heme oxygenase-1 (HO-1). However, hitherto its role in blood vessel formation was modestly examined. Particularly, although Nrf2 shown to affect hematopoietic stem cells, it not tested bone marrow-derived cells (PACs). Here we investigated angiogenic properties of PACs, endothelial inflammation-related revascularization.Treatment with cytokines increased...
Heme oxygenase-1 (HO-1), a cytoprotective, pro-angiogenic and anti-inflammatory enzyme, is strongly induced in injured tissues. Our aim was to clarify its role cutaneous wound healing. In wild type mice, maximal expression of HO-1 the skin observed on 2(nd) 3(rd) days after wounding. Inhibition by tin protoporphyrin-IX resulted retardation closure. Healing also delayed deficient where lack could lead complete suppression reepithelialization formation extensive lesions, accompanied impaired...
Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression induced in response oxidative stress. Its overexpression has been suggested as strategy improving survival of transplanted muscle precursors.Here we demonstrated that HMOX1 inhibits differentiation myoblasts modulates miRNA processing: downregulates Lin28 DGCR8, lowers the total pool cellular miRNAs, specifically blocks induction myomirs. Genetic or...
Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, the number of GT repeats can influence occurrence cardiovascular diseases. We elucidated effect this polymorphism on endothelial cells isolated from newborns different genotypes.On basis expression, we classified alleles into 3 groups: short (S) (most active, < or = 23), medium (moderately GT=24 28), long...
Abstract Endothelial cells (ECs) play a crucial role in the development and propagation of severe COVID-19 stage as well multiorgan dysfunction. It remains, however, controversial whether COVID-19-induced endothelial injury is caused directly by infection ECs with SARS-CoV-2 or via indirect mechanisms. One major concerns raised contradictory data supporting denying presence ACE2, binding receptor, on EC surface. Here, we show that primary human pulmonary artery possess ACE2 capable...
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that can be down-regulated in diabetes. Its importance for mature endothelium has been described, but its role proangiogenic progenitors not well known. We investigated the effect of HO-1 on angiogenic potential bone marrow-derived cells (BMDCs) and blood flow recovery ischemic muscle diabetic mice.Lack decreased number endothelial progenitor (Lin(-)CD45(-)cKit(-)Sca-1(+)VEGFR-2(+)) murine marrow, inhibited cultured BMDCs, affecting their...
Heme oxygenase-1 (HO-1) is an antioxidative and cytoprotective enzyme, which may protect neoplastic cells against anticancer therapies, thereby promoting the progression of growing tumors. Our aim was to investigate role HO-1 in cancer induction. Experiments were performed HO-1(+/+), HO-1(+/-), HO-1(-/-) mice subjected chemical induction squamous cell carcinoma with 7,12-dimethylbenz[a]anthracene phorbol 12-myristate 13-acetate. Measurements genes livers evidenced systemic oxidative stress...
Epidemiologic studies suggest that diabetes is associated with an increased risk of cancer. Concurrently, clinical trials have shown metformin, which a first-line antidiabetic drug, displays anticancer activity. The underlying mechanisms for these effects are, however, still not well recognized. Methods based on atomic force microscopy (AFM) were used to directly evaluate the influence metformin nanomechanical and adhesive properties endothelial cancer cells in chronic hyperglycemia. AFM...
Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent apoptotic fate remains, however, poorly recognized. Nrf2 an important transcription factor orchestrating adaptive response cellular stress. Here, we show that both human primary endothelial (ECs) murine aortas lacking signaling are but unexpectedly do not encounter damaging oxidative Instead, they exhibit markedly increased...